The physiology of substance P in the rabbit retina (original) (raw)

The study investigates the physiological role of substance P (SP) in rabbit retinal neurons, revealing that SP is localized to amacrine and ganglion cells. Using electrophysiological methods, it demonstrates that SP enhances excitability in brisk ganglion cells, particularly when synaptic transmission is blocked, while showing minimal effects on horizontal cells and the electroretinogram (ERG). The findings suggest that SP influences inner retinal neuron excitability without substantially impacting the receptive field properties of ganglion cells.