Targeted protein degradation mechanisms (original) (raw)
Current Challenges in Small Molecule Proximity-Inducing Compound Development for Targeted Protein Degradation Using the Ubiquitin Proteasomal System
Markus Muellner
Molecules
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Ubiquitin: A Magical Bullet for Protein Degradation
sudhanshu nayak
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Two-Headed PROTAC: An Effective New Tool for Targeted Protein Degradation
Marie Wehenkel
ChemBioChem, 2010
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Ubiquitin-mediated proteolysis: biological regulation via destruction
Amir Orian
BioEssays, 2000
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High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics
Jeffrey Simard
SLAS Discovery, 2021
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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
Sonia Rocha
Nature communications, 2017
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Proteome-scale induced proximity screens reveal highly potent protein degraders and stabilizers
Juline POIRSON
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The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates
Kyle Kovary
The Journal of biological chemistry, 2013
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Placing a Disrupted Degradation Motif at the C Terminus of Proteasome Substrates Attenuates Degradation without Impairing Ubiquitylation
Yuval Reiss
Journal of Biological Chemistry, 2013
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Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates
Nico Dantuma
The FASEB Journal, 2009
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Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin–proteasome linked protein degradation
Dieter H Wolf
Biochemical and Biophysical Research Communications, 2006
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A tale of two tails - efficient profiling of protein degraders by specific functional and target engagement readouts
Alexey Chernobrovkin
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Molecular Machines for Protein Degradation
Hans Brandstetter
ChemBioChem, 2005
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Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy
Mladen Koravović, Journal of the Serbian Chemical Society, Gordana Tasić
Journal of the Serbian Chemical Society, 2022
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Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes
John Hanna
Molecular & Cellular Proteomics, 2010
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A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications
Ryan Whatling
SLAS Discovery, 2021
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An unstructured initiation site is required for efficient proteasome-mediated degradation
LIN TIAN
Nature Structural & Molecular Biology, 2004
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Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation
Lars Ellgaard
FEBS Journal, 2012
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C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation
Nico Dantuma
Nature Communications, 2011
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Ubiquibodies, Synthetic E3 Ubiquitin Ligases Endowed with Unnatural Substrate Specificity for Targeted Protein Silencing
Jeffrey Varner
Journal of Biological Chemistry, 2014
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Proteasomes Can Degrade a Significant Proportion of Cellular Proteins Independent of Ubiquitination
Ekaterina Viktorova
Journal of Molecular Biology, 2009
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Ubiquitin, proteasomes, and the regulation of intracellular protein degradation
Mark Hochstrasser
Current Opinion in Cell Biology, 1995
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A Label-free Quantitative Proteomics Strategy to Identify E3 Ubiquitin Ligase Substrates Targeted to Proteasome Degradation
Sandrine UTTENWEILER
Molecular & Cellular Proteomics, 2009
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To degrade or release: ubiquitin-chain remodeling
Andreas Matouschek, Daniel Kraut
Trends in Cell Biology, 2007
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Editorial: E3 Ubiquitin Ligases: From Structure to Physiology
Victor Bolanos-garcia
Frontiers in Physiology, 2020
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Targeted degradation via direct 26S proteasome recruitment
Aaron Wecksler
Nature Chemical Biology
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Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles
Yelena Kravtsova-ivantsiv
Proceedings of the National Academy of Sciences of the United States of America, 2019
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Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs that Promote Degradation of Aiolos and/or GSPT1
Afshin Mahmoudi
Journal of medicinal chemistry, 2017
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Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach
Heinz-josef Lenz
Clinical Cancer Research, 2014
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The ubiquitin-mediated proteolytic pathway as a therapeutic area
M. Pagano
Journal of Molecular Medicine, 1997
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Structural basis of PROTAC cooperative recognition for selective protein degradation
Alessio Ciulli
Nature chemical biology, 2017
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Protein Degradation by the Ubiquitin–Proteasome Pathway in
William Mitch
Journal of the American …, 2006
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