Enterohepatic bile salt transporters in normal physiology and liver disease (original) (raw)
The paper discusses the critical role of enterohepatic bile salt transporters in maintaining bile flow and lipid metabolism, highlighting the mechanisms and transport proteins involved in bile salt circulation within the body. The review emphasizes the regulatory networks controlling these transporters and the implications of their dysfunction in liver diseases. Furthermore, advances in understanding the signaling roles of bile acids as well as their synthesis pathways are explored, providing insight into how disruptions in normal transport processes can lead to cholestatic liver diseases.