The relation between mean platelet volume and coronary collateral vessels in patients with acute coronary syndromes (original) (raw)
Related papers
The association between mean platelet volume and coronary collateral circulation
PubMed, 2013
Background: Platelets are important in the pathogenesis of atherosclerotic complications. Higher mean platelet volume (MPV) levels are related to greater in vitro aggregation, and have been identified as an independent risk factor for myocardial infarction, and for death or recurrent vascular events. Aim: To determine the relationship between MPV and the coronary collateral circulation. Methods: The sample consisted of 96 patients with coronary artery disease, and patients were separated into two groups according to their poorly developed or well-developed collateral circulation. Coronary collateral vessels were analyzed according to the Cohen and Rentrop grading system of 0-3. Results: All analyses were conducted using SPSS 11.5 (SPSS for Windows 11.5, Chicago, IL, USA). Continuous variables were expressed as mean ± SD, and categorical variables were expressed as percentages. Comparison of categorical and continuous variables between the group with well-developed coronary collateral vessels and the group with poorly developed vessels was performed using the chi-squared test and independent samples t-test, respectively. Platelet count and MPV values were similar between the two groups. Conclusions: Our study found that MPV levels are not related to coronary collateral circulation.
Mean Platelet Volume in Acute Coronary Syndrome: A Prospective Observational Study
Journal of Evolution of medical and Dental Sciences, 2015
AIM: To study the mean platelet volume in acute coronary syndrome patients and compare it with non acute coronary syndrome patients. MATERIALS AND METHODS: This is a case- control study carried out between November 2012 to October 2013 at the Department of Internal Medicine and the Department of Cardiology, Government Medical College, Jammu. A total of 200 subjects were evaluated after applying proper inclusion and exclusion criterias. These included 100 cases with acute coronary syndromes and 100 age and sex matched controls. Measurement of mean platelet volume was done in both and and analysis of other variables like hypertension, diabetes, body mass index, smoking, alcohol, family history, etc was done with respect to mean platelet volume. The results were compiled statistically using student t -test and ANOVA. RESULTS: The mean age of cases was 47.60±7.12 years, while the mean age of controls was 44.34 ± 7.44 years. The mean platelet volume in cases was 9.33 ± 1.03 fL, while in ...
Introduction: Platelet activation and aggregation play a role in the pathophysiology of coronary heart disease. Platelet plays an important role in contributing to thrombus formation after coronary plaque rupture. In addition, platelets also play a role in the formation of atherosclerotic plaques. Mean Platelet Volume (MPV) is an index of platelet size that can be correlated with the functional status of platelets. In patients with acute coronary syndrome (ACS), increased MPV is associated with a degree of coronary artery disease lesion.Aim:To know the association of MPV with degree of coronary artery lesion so that MPV can be used as a marker to estimate the severity of coronary artery lesions in ACS patients.Methods: A cross sectional study of 50 patients with SKA. MPV examination of routine blood and vessel score assessment of angiography was performed. The study was conducted in RSUP. H. Adam Malik Medan. Analysis using Chi Square.Results: Mean of MPV content in this study is 10.15 ± 0.798 fl. Chi-square statistical test between MPV and vessel score (p = 0,068).Conclusion: There was no significant association between MPV levels and the number of coronary artery lesions described by Vessel score.
Association of mean platelet volume and acute coronary syndrome
International Journal of Research in Medical Sciences, 2017
Background: Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque and are a consequence of platelet rich coronary thrombus formation. Larger platelets are haemostatically more active and and hence carry risk for developing coronary thrombosis leading to ACS. Platelet parameters especially mean platelet volume (MPV) could be used as an important and reliable marker in early detection of ACS when the patients come to emergency department with chest pain. The primary objective is to study the association between mean platelet volume and acute coronary syndrome. The secondary objectives are to analyse if there is a statistically significant difference in mean platelet volume between Non-ST elevation (NSTEMI) and ST-elevation Myocardial Infarction (STEMI) and between double vessel disease (DVD) and triple vessel disease (TVD).Methods: A total of 260 patients were included in the study depending on the inclusion and exclusion criteria. After dividing the ...
Atherosclerosis, 2009
Background: Platelets play a central role in the pathogenesis of coronary artery disease. Mean platelet volume (MPV) is an indicator of platelet activation, and has been demonstrated to be correlated with platelet reactivity. The aim of the current study was to investigate whether mean platelet volume is associated with the extent of coronary artery disease. Methods: We measured MPV in 1411 consecutive patients undergoing coronary angiography. All angiograms were analyzed by two investigators blinded of clinical data. Significant coronary artery disease was defined as stenosis >50% in at least 1 coronary vessel. We additionally measured Carotid Intima-Media Thickness (IMT) in 359 patients. The relationship between MPV and platelet aggregation was evaluated by PFA-100 in 50 consecutive patients who were not taken any antiplatelet therapy, and in a cohort of patients who were on aspirin by PFA-100 (n = 161) and Multiplate (n = 94). Results: Patients were divided into three groups according to tertiles of MPV. Patients with higher MPV were slightly older (p = 0.038), with larger prevalence of diabetes (p < 0.0001), hypertension (p = 0.008), previous CVA (p = 0.041), less often with stable angina (p = 0.043) and family history of CAD (p = 0.011), more often on statins (p = 0.012), and diuretics (p = 0.007). MPV was associated with baseline glycaemia (p < 0.0001) and red blood cell count (p = 0.056), but inversely related to platelet count (p < 0.0001). MPV was not associated with the extent coronary artery disease (p = 0.71) and carotid IMT (p = 0.9). No relationship was found between MPV and platelet aggregation. Conclusion: This study showed that MPV is not related to platelet aggregation, the extent of coronary artery disease and carotid IMT. Thus, this parameter cannot be considered as a marker of platelet reactivity or a risk factor for coronary artery disease.
2018
DOI: 10.21276/sjams.2018.6.9.79 Abstract:Coronary artery disease is major health problem. Various markers are being studied to diagnose significant coronary artery disease. We conducted this prospective observational study to find any association of mean platelet volume (MPV), SGOT and CPKMB with significant coronary artery disease.A total of 110 patients with acute coronary syndromes were included in the study. All patients underwent coronary angiogram and percutaneous intervention whenever indicated. Association of MPV, SGOT and CPK-MB was tested with presence of significant coronary disease. MPV was significantly higher in hypertensive & those who required coronary intervention (p value 0.014 &<0.001 respectively). Two or three vessel-involved-subjects were having significantly higher MPV than those with no or single major vessel involvement. (two vessel v/s normal or single vessel, MPV 10.66 +/-1.52 p value 0.03, three vessel v/s normal or single vessel, MPV 11.55+/-1.51 p va...
Elevated mean platelet volume is a marker of acute coronary syndrome
2013
Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque and are a consequence of platelet rich coronary thrombus formation. Platelet parameters especially MPV could be an important and reliable markers in early detection of ACS when other markers are not available.This quasi- experimental study was conducted from September 2011 to August 2012 in the Department of Clinical Pathology, BSMMU, in collaboration with Department of Cardiology, BSMMU and BIRDEM on 79 patients with ACS diagnosed on the basis of clinical history, Electrocardiographic changes and increased cardiac markers especially troponin I with 63 subjects enrolled as control. For determination of platelet parameters, the blood sample was obtained from all patients of ACS before anti-platelet therapy when patient attended in the Cardiac emergency department and on 5th day of ongoing anti-platelet therapy in coronary care unit.The sensitivity, specificity, accuracy, positive and negative pred...
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)
Background: Coronary Heart Disease (CHD) is currently one of main causes and the first death in developed and developing countries, including Indonesia. CHD appeared with the clinical appearance of asymptomatic, stable angina pectoris until acute coronary syndrome. ACS is a progressively CHD and takes parameters that describe the process pathogenesis. MPV and platelet count are two parameters in the complete blood count which reflect the activity of platelets in CHD.Objective: This study is to investigate the differences Mean Platelet Volume and Platelet Count in CHD with ACS compared to non ACS.Methods: A cross-sectional study was conducted with collecting data from the medical records of patients with CHD who underwent treatment in the dr. Kariadi General Hospital Medical Center Semarang, the period of January - December 2019. Eighty subjects of 20 non-ACS patients and 60 ACS patients were included in this study which is Mean Platelet Volume and Platelet Count in hematology labora...
Correlation of platelet volume indices in coronary artery disease and control groups
2016
Background: Coronary artery disease (CAD) stems as a consequence of atherosclerotic plaque with associated platelet rich coronary thrombus formation. Larger platelets are metabolically more active and have a greater thrombogenic potential compared to smaller platelets. Aims: The present study was designed to evaluate the platelet volume indices in coronary artery disease patients with documented angiogram abnormalities and to correlate the significance in comparison to normal controls. Materials and Methods: This was a comparative study of 128 subjects; 51 patients of CAD with angiogram evidence of single vessel, double vessel and triple vessel disease and 77 controls. Blood samples were collected in standardised EDTA tubes and analysed using a five part analyser Sysmex XS-800-I. The controls were healthy voluntary blood donors and were compared with CAD patients admitted for angiography. Results: Patients with abnormal angiogram findings had a higher MPV and PDW than the normal controls. MPV showed a statistically significant correlation between CAD and control groups with a P value of 0.001. Conclusion: Platelet volume indices, specifically Mean platelet volume can be of benefit in detecting coronary artery disease patients who may probably show abnormality in angiogram findings.
International Journal of Cardiology, 2010
Objective: Mean platelet volume (MPV), a reliable indicator of platelet size and its metabolic activity has consistently been shown to rise in patients presented with acute coronary syndromes. However, value of this simply obtained parameter has not been evaluated extensively in patients with stable coronary artery disease. Therefore, the aim of the present study is to assess the relationship between MPV and the presence as well as extent of coronary artery disease in patients who underwent coronary angiography for stable chest pain. Methods: A total of 540 patients (350 male, 190 female; mean age: 59.6±11.4 years) were consecutively included in the study. The patients were divided into four groups according to the presence and extent of coronary artery disease: Group 1 consisted of patients with no significant coronary artery disease, group 2 consisted of patients with one vessel disease, group 3, patients with two vessel disease and group 4, patients with three vessel disease. Also, for more accurate evaluation of extension of coronary artery disease, Gensini score of each coronary angiogram was calculated. Results: There were 159 (29.5%) patients in group 1, 169 (31.2%) patients in group 2, 110 (20.4%) in group 3, 102 (18.9%) in group 4. As expected, significant differences were present among groups regarding mean age and other coronary risk factors including gender, hypertension, diabetes mellitus, hyperlipidemia, smoking and family history of ischemic heart disease. However, there were no significant differences among groups in both platelet counts and MPV values (8.48±0.97fL for group 1, 8.51±1.16fL for group 2, 8.55±0.93fL for group 3 and 8.58±0.94fL for group 4, p=0.86). Although Gensini score was found to be significantly correlated with age (r=0.20, p<0.001), plasma uric acid level (r=0.22, p<0.001), white blood cell count (r=0.13, p=0.003), hemoglobin level (r=-0.11, p=0.009), fasting blood glucose (r=0.21, p=0.004) and high density lipoprotein level (r=-0.18, p<0.001), no significant association was detected between MPV and Gensini score values (r=0.07, p=0.12). Conclusions: In this study, one of the largest studies assessing the relationship between MPV and extension of coronary atherosclerosis in patients with stable coronary artery disease to date, no association between MPV and the presence and extent of coronary atherosclerosis was found. However, in addition to major coronary risk factors, plasma uric acid, high density lipoprotein, hemoglobin level and white blood cell count were found to be significantly correlated with coronary artery disease extension evaluated by Gensini score.