Long Term Analysis Changes of 35 Biochemical and Biolelecrical Parameters in a Dialytic Population (original) (raw)

H3GlY6, Canada administration of genetically engineered cells can lower urea, uric acid, and creatinine in uremic rats. The present study is to see whether this can lower K+, P, el-, and P in uremic rats. B) Methods used: Genetically engineered E. coli DH5 cells are encapsulated in artificial cells. The efficacy for the removal of electrolytes was analyzed in-vitro in batch bioreactors and in-vivo in daily oral administration to partially nephrectomized male Wistar rats. C) Results summary: In-vitro: Significant lowering of plasma K' , P, Na' , and CI-occurs in in-vitro experiments in batch bioreactors. In-vivo experiments in uremic rats show that oral administration also resulted in lowering of plasma electrolytes levels. For example, plasma K+ decreases from 5.66 +I. 15 (mmol/L) to 4.23 0.90 (mmol/L), plasma P from 2.44 2 0.56 (mmol/L) to 1.54 5 0.59 (mmoVL), plasmaNa+ 1462 6.30 (mmol/L) to 13 1.20+ 8.60 (mmol/L), plasma Cf from 206.00 5 49.70 (mmol/L) to 101.00 5 15.00 (mmol/L), and alkaline phosphatase from 212.33 5 63.21 (dl) to 87.66 24.54 (dl). On discontinuation of the therapy, electrolyte levels increased again. Ref.: www.artcell.mcgill.ca A) Purpose of study: We have shown earlier that oral Mean Arterial Blood Pressures during Extended Daily Dialysis (EDD) vs. Intermittent Hemodialysis in Intensive Care Unit (ICU) Patients.

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