Improving the Detection Accuracy of an Ag/Au Bimetallic Surface Plasmon Resonance Biosensor Based on Graphene (original) (raw)
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Effect of Semiconductor on Sensitivity of a Graphene-Based Surface Plasmon Resonance Biosensor
Plasmonics, 2015
In this theoretical study, the effect of semiconductor on sensitivity of a graphene-based surface plasmon resonance (SPR) biosensor has been presented. Different semiconductors such as silicon (Si), germanium (Ge) and wurtzite III-V nitrides (AlN, GaN and InN) have been placed in between active silver (Ag) metal and graphene layer. Our simulation result shows that addition of semiconductor layer enhances the sensitivity by a factor of 3.76, 2.19, 3.82, 3.94 and 4.17 respectively for Si, Ge, InN, GaN and AlN. Also, we have examined the field enhancement factor due to above semiconductors and found maximum field intensity enhancement for the case of AlN. The analysis shows that best performance is achieved for red He-Ne laser light when optimized thicknesses of silver, AlN and graphene layer are 55, 14 and 0.34 nm (monolayer of graphene), respectively. More specifically, AlN would be a better choice for biosensing application in SPR biosensor.
GRAPHENE COATED SURFACE PLASMON RESONANCE BIOSENSOR FOR BIOMEDICAL APPLICATIONS
Thesis Book, 2016
A graphene coated high sensitive surface plasmon resonance (SPR) biosensor is presented for biomedical applications specialy the detection of DNA Hybridization. The detection technique is attenuated total reflection (ATR) method, which is worked on the adsorption of biomolecules and refractive index change near the sensor surface. This proposed sensor is sensed nucleotides bonding happened between double-stranded (dsDNA) helix structure, based on the change of surface plasmon resonance (SPR) angle-the change of minimum reflectance (Rmin) attributor and the resonance frequency characteristics (RFC)-maximum transmittance (Tmax) attributor. Numerical analysis shows that the variation of RFC and SPR angle for mismatched DNA strands is quiet negligible whereas that for complementary DNA strands is considerably countable. Here, sensor is designed based on graphene material as biomolecular recognition elements (BRE) and the sharp SPR curve of gold (Au). Graphene is used to perform faster immobilization between target DNA and probe DNA.This sensor can successfully detect the hybridization of target DNAs to the probe DNAs pre-immobilized on graphene with capability to distinguish single-base mismatch. In additionally the methodology of this study is presented for diagnosis of the single-nucleotide polymorphisms (SNP) which uses a graphene coated DNA sensor. Numerical calculations show that the proposed graphene coated on gold SPR biosensor has 1 + 0.4 L; (where L is the number of graphene sub-layers) times more sensitivity than the conventional SPR biosensor when SPR angle-Rmin attributor is used as detecting parameters. The enhanced sensitivity is due to increased SPR angle change about 40L% by adding graphene layer and using the optical property of graphene. On the other hand, use of RFC-Tmax attributor enhances 1+.95 L sensitivity comparing with conventional SPR sensor. The proposed frequency-angle readout based SPR sensor could potentially open a new window of detection for biomolecular interactions. We also highlight the advantage of using graphene sublayer by performing the sensitivity analysis.
Sensitivity enhancement of graphene coated surface plasmon resonance biosensor
Optical and Quantum Electronics, 2017
In this paper, a highly sensitive surface plasmon resonance biosensor is presented using angular interrogation. Due to low sensitivity of conventional biosensor, graphene/two-dimensional transition metal are used in surface plasmon resonance biosensor to improve the sensitivity. Here, we propose a seven layer model of biosensor which shows by incorporating silicon layer in addition of transition metal dichalcogenides MoS 2 and graphene, the sensitivity of the proposed SPR biosensor can be greatly enhanced than the conventional gold film SPR sensors. It is observed that the highest sensitivity can be obtained by optimizing the structure with 8 nm thickness of silicon layer, one layer of MoS 2 and one layer of graphene. The highest sensitivity of our proposed sensor is 210°/ RIU.
Optik, 2018
This paper describes the effect of adding graphene layers in prism and planar waveguide based surface plasmon resonance biosensors using angular interrogation mode. The proposed sensors are designed based on graphene material as biomolecular recognition elements (BRE) and the sharp SPR curve of gold (Au). Our calculations show that the proposed graphene in prism and planar waveguide based SPR biosensors have 1 + 0.40 L and 1+0.45 L; (where L is the number of graphene layers) times more sensitivity than the conventional SPR biosensor respectively. The enhanced sensitivity is due to increased SPR angle change about 40 L% and 45 L% by adding graphene layer and using the optical property of graphene. We also investigate the performance of proposed biosensors in terms of sensitivity using graphene sublayers. The compact size, prism and planar waveguide based design, and very high sensitive-these characteristics are expected to make these biosensors preferred choice for biomedical applications, as compared to other contemporary biosensors.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2011
This paper investigates the enhancement of the sensitivity and adsorption efficiency of a localized surface plasmon resonance (LSPR) biosensor that includes a layer of graphene sheet on top of the gold layer. For this purpose, biomolecular interactions of biotin-streptavidin with the graphene layer on the gold thin film are monitored. The performance of the LSPR graphene biosensor is theoretically and numerically assessed in terms of sensitivity and adsorption efficiency under varying conditions, including the thickness of biomolecule layer, number of graphene layers and operating wavelength. Enhanced sensitivity and improved adsorption efficiency are obtained for the LSPR graphene biosensor in comparison with its conventional counterpart. It is found that the LSPR graphene biosensor has better sensitivity with lower operating wavelength and larger number of graphene layers.
A B S T R A C T We demonstrate a highly sensitive Au-MoS 2-Graphene based hybrid surface plasmon resonance (SPR) biosensor for the detection of DNA hybridization. The performance parameters of the proposed sensor are investigated in terms of sensitivity, detection accuracy and quality factor at operating wavelength of 633 nm. We observed in the numerical study that sensitivity can be greatly increased by adding MoS 2 layer in the middle of a Graphene-on-Au layer. It is shown that by using single layer of MoS 2 in between gold and graphene layer, the proposed biosensor exhibits simultaneously high sensitivity of 87.8 deg/RIU, high detection accuracy of 1.28 and quality factor of 17.56 with gold layer thickness of 50 nm. This increased performance is due to the absorption ability and optical characteristics of graphene biomolecules and high fluorescence quenching ability of MoS 2. On the basis of changing in SPR angle and minimum reflectance, the proposed sensor can sense nucleotides bonding happened between double-stranded DNA (dsDNA) helix structures. Therefore, this sensor can successfully detect the hybridization of target DNAs to the probe DNAs pre-immobilized on the Au-MoS 2-Graphene hybrid with capability of distinguishing single-base mismatch.
2021
A biosensor based on the modified Kretschmann configuration is proposed here. The sensitivity of the conventional prism-based sensor using angular interrogation is low. To enhance the sensor's performance, layers of zinc sulfide (ZnS) and graphene have been deposited over the metal layer. The angular interrogation technique is used to analyze the performance of the sensor. The thickness of the Ag metal has been optimized. The thickness of the Ag metal is taken as 50 nm because minimum reflectance has been achieved. With the combinations of the four layers of ZnS and one graphene layer, the maximum sensitivity attained is 305o/RU. Performance parameters such as detection accuracy, FWHM, and quality factor of the sensor have been evaluated as obtained as 0.33 deg-1, 3.05 deg, 100.7 RIU-1, respectively. The proposed sensor has potential application in the field of biochemical and biological analyte detection.
Graphene Based Nano Bio-sensor: Sensitivity Improvement
Scientia Iranica, 2017
In this paper, we attempt to present a multilayer-structure biosensor. A graphene-based Surface Plasmon Resonance (SPR) biosensor is considered as a structure, which o ers enhancement of sensitivity in comparison with the conventional biosensors. The sensitivity improvement caused by the presence of graphene is discussed through monitoring of the biomolecular interactions and following that the Refractive Index (RI) changes. For this purpose, an RI change, which increases during the course of biomolecular interaction, is considered from 1.462 to 1.52. Our numerical results show that the proposed SPR biosensor with a graphene layer can provide a better sensitivity due to the eld distribution at the binding region. This paper investigates the Sensitivity Enhancement Factor (SEF) according to the S-parameters and the e ects of design parameters such as thicknesses of the gold and graphene layers and the refractive index change during the course of DNA hybridization in this biosensor.
Materials
The emergence of unintentional poisoning and uncontrolled vector diseases have contributed to sensor technologies development, leading to the more effective detection of diseases. In this study, we present the combination of graphene-based material with surface plasmon resonance technique. Two different graphene-based material sensor chips were prepared for rapid and quantitative detection of dengue virus (DENV) and cobalt ion (Co2+) as an example of typical metal ions. As the fundamental concept of surface plasmon resonance (SPR) sensor that relies on the refractive index of the sensor chip surface, this research focused on the SPR signal when the DENV and Co2+ interact with the graphene-based material sensor chip. The results demonstrated that the proposed sensor-based graphene layer was able to detect DENV and Co2+ as low as 0.1 pM and 0.1 ppm respectively. Further details in the detection and quantification of analyte were also discussed in terms of sensitivity, affinity, and se...