Stimulation of glucose phosphorylation by fructose in isolated rat hepatocytes (original) (raw)

This study investigates the role of fructose in stimulating glucose phosphorylation in isolated rat hepatocytes. The phosphorylation of glucose was significantly enhanced by fructose at low concentrations, specifically showing a 2-4 fold increase in rates at 5 mM glucose. Key findings suggest the involvement of fructose I-phosphate in mediating the stimulation of glucokinase, indicating a potential regulatory mechanism in hepatic glucose metabolism. The results have implications for understanding the metabolic interactions between fructose and glucose in liver cells.