Relevance of KIR and HLA Genotypes in Viral Infection by HSV (original) (raw)

Abstract

Introduction Herpesvirus Simplex (HSV) is a very common infectious agent, which leads to an immune response produced, initially, by Natural Killer (NK) cells. The regulation of these cells is mediated by interaction between molecules of Human Leukocyte Antigen (HLA) and Killer Immunoglobulin Like Receptors (KIR). The genes for these receptors may express two groups of haplotypes. Group A has only one activating KIR, group B presents more than one of these receptors, with possible consequences in response to diseases. Aim Relate the KIR and HLA genotypes on the duration and severity of HSV-1 infection. Material and Methods The study focused on a population consisting in a cohort of 24 students, seropositive for HSV-1, from College of Health Technology of Coimbra. The HLA typing was performed by PCR - Polymerase Chain Reaction-Sequence Specific Oligonucleotide (PCR-SSO) and KIR typing method was Polymerase Chain Reaction-Sequence Specific Oligonucleotide reverse (PCR-rSSO). Results In...

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