Bimodal learning via trilogy of skip-connection deep networks for diabetic retinopathy risk progression identification (original) (raw)

ARTICLE Deep learning algorithm predicts diabetic retinopathy progression in individual patients

The global burden of diabetic retinopathy (DR) continues to worsen and DR remains a leading cause of vision loss worldwide. Here, we describe an algorithm to predict DR progression by means of deep learning (DL), using as input color fundus photographs (CFPs) acquired at a single visit from a patient with DR. The proposed DL models were designed to predict future DR progression, defined as 2-step worsening on the Early Treatment Diabetic Retinopathy Diabetic Retinopathy Severity Scale, and were trained against DR severity scores assessed after 6, 12, and 24 months from the baseline visit by masked, well-trained, human reading center graders. The performance of one of these models (prediction at month 12) resulted in an area under the curve equal to 0.79. Interestingly, our results highlight the importance of the predictive signal located in the peripheral retinal fields, not routinely collected for DR assessments, and the importance of microvascular abnormalities. Our findings show the feasibility of predicting future DR progression by leveraging CFPs of a patient acquired at a single visit. Upon further development on larger and more diverse datasets, such an algorithm could enable early diagnosis and referral to a retina specialist for more frequent monitoring and even consideration of early intervention. Moreover, it could also improve patient recruitment for clinical trials targeting DR. npj Digital Medicine (2019) 2:92 ; https://doi.

Deep learning algorithm predicts diabetic retinopathy progression in individual patients

npj Digital Medicine, 2019

The global burden of diabetic retinopathy (DR) continues to worsen and DR remains a leading cause of vision loss worldwide. Here, we describe an algorithm to predict DR progression by means of deep learning (DL), using as input color fundus photographs (CFPs) acquired at a single visit from a patient with DR. The proposed DL models were designed to predict future DR progression, defined as 2-step worsening on the Early Treatment Diabetic Retinopathy Diabetic Retinopathy Severity Scale, and were trained against DR severity scores assessed after 6, 12, and 24 months from the baseline visit by masked, well-trained, human reading center graders. The performance of one of these models (prediction at month 12) resulted in an area under the curve equal to 0.79. Interestingly, our results highlight the importance of the predictive signal located in the peripheral retinal fields, not routinely collected for DR assessments, and the importance of microvascular abnormalities. Our findings show ...

Predicting Severity of Diabetic Retinopathy using Deep Learning Models

International Research Journal on Advanced Science Hub, 2021

This paper presents deep learning models for the classification of Diabetic Retinopathy (DR) grades. The goal of this research is to find and create a deep learning model that will help us identify the image with high accuracy into one of the five phases of the DR as no DR, mild, moderate, severe, and proliferative DR.The whole work is developed using four steps. The first, using Ben Graham's pre-possessing form, the fundus images were pre-processed. Secondly, in order to train the models, the preprocessed images are contributed to the deep learning algorithm. The third,deep learning models such as Deep CNN, Dense Net, and Group 19 Visual Geometry (VGG19) are developed to predict the severity of the DR. The APTOS Blindness Detection dataset is used to train the proposed deep learning models. Since the data set is imbalanced in nature, the issue of training bias contributes to it. Therefore, at the time of training the models, class weight technique is used to eliminate the training bias problem. In the case of DR grading structures, the proposed deep learning models work well. The Dense Net has been found to work better than the other two models.

Deep Learning for Diabetic Retinopathy Analysis: A Review, Research Challenges, and Future Directions

Sensors

Deep learning (DL) enables the creation of computational models comprising multiple processing layers that learn data representations at multiple levels of abstraction. In the recent past, the use of deep learning has been proliferating, yielding promising results in applications across a growing number of fields, most notably in image processing, medical image analysis, data analysis, and bioinformatics. DL algorithms have also had a significant positive impact through yielding improvements in screening, recognition, segmentation, prediction, and classification applications across different domains of healthcare, such as those concerning the abdomen, cardiac, pathology, and retina. Given the extensive body of recent scientific contributions in this discipline, a comprehensive review of deep learning developments in the domain of diabetic retinopathy (DR) analysis, viz., screening, segmentation, prediction, classification, and validation, is presented here. A critical analysis of th...

Literature Survey on Diabetic Retinopathy Classification Using Deep Learning

IJRASET, 2021

Diabetic retinopathy (DR) is a medical condition that damages eye retinal tissues. Diabetic retinopathy leads to mild to complete blindness. It has been a leading cause of global blindness. The identification and categorization of DR take place through the segmentation of parts of the fundus image or the examination of the fundus image for the incidence of exudates, lesions, microaneurysms, and so on. This research aims to study and summarize various recent proposed techniques applied to automate the process of classification of diabetic retinopathy. In the current study, the researchers focused on the concept of classifying the DR fundus images based on their severity level. Emphasis is on studying papers that proposed models developed using transfer learning. Thus, it becomes vital to develop an automatic diagnosis system to support physicians in their work. I.

Classification of Diabetic Retinopathy by Deep Learning

2024

Diabetic retinopathy (DR), which is a leading cause of adult blindness, primarily affects individuals with diabetes. The manual diagnosis of DR, with the assistance of an ophthalmologist, has proven to be a time-consuming and challenging process. Late detection of DR is a significant factor contributing to the progression of the disease. To address this issue, the present study utilizes deep learning (DL) and transfer learning algorithms to analyze different stages of DR and precisely detect the condition. Using a large dataset comprising approximately 60,000 images, this study employs ResNet-101, DenseNet121, InceptionResNetV2, and EfficientNetB0 DL models to automatically assess the progression of DR. Images of patients' eyes are inputted into the models, and the DL architectures are adapted to extract relevant features from the eye images. The study's findings demonstrate that DenseNet121 outperforms ResNet-101, InceptionResNetV2, and EfficientNetB0 in accurately classifying the five stages of DR. The accuracy of the models was 97%, 96%, 95%, and 94%, respectively. These results underscore the effectiveness of DL in achieving an accurate and comprehensive classification of retinitis pigmentosa. By enabling accurate and timely diagnosis of DR, the application of DL techniques significantly contributes to the field of ophthalmology, facilitating improved treatment decisions for patients.

Deep Neural Network for Predicting Diabetic Retinopathy from Risk Factors

Mathematics

Extracting information from individual risk factors provides an effective way to identify diabetes risk and associated complications, such as retinopathy, at an early stage. Deep learning and machine learning algorithms are being utilized to extract information from individual risk factors to improve early-stage diagnosis. This study proposes a deep neural network (DNN) combined with recursive feature elimination (RFE) to provide early prediction of diabetic retinopathy (DR) based on individual risk factors. The proposed model uses RFE to remove irrelevant features and DNN to classify the diseases. A publicly available dataset was utilized to predict DR during initial stages, for the proposed and several current best-practice models. The proposed model achieved 82.033% prediction accuracy, which was a significantly better performance than the current models. Thus, important risk factors for retinopathy can be successfully extracted using RFE. In addition, to evaluate the proposed pr...

Deep Learning for the Detection of Diabetic Retinopathy

International Journal for Research in Applied Science & Engineering Technology (IJRASET), 2022

Diabetic retinopathy (DR) is also called diabetic eye disease, when retina is damaged due to diabetes. It can eventually lead to blindness. It is an ocular manifestation of diabetes. Despite these intimidating statistics, research indicates that at least 90% of these new cases could be reduced if there is proper treatment and monitoring of the eyes [1].

A Survey on Deep-Learning-Based Diabetic Retinopathy Classification

Diagnostics

The number of people who suffer from diabetes in the world has been considerably increasing recently. It affects people of all ages. People who have had diabetes for a long time are affected by a condition called Diabetic Retinopathy (DR), which damages the eyes. Automatic detection using new technologies for early detection can help avoid complications such as the loss of vision. Currently, with the development of Artificial Intelligence (AI) techniques, especially Deep Learning (DL), DL-based methods are widely preferred for developing DR detection systems. For this purpose, this study surveyed the existing literature on diabetic retinopathy diagnoses from fundus images using deep learning and provides a brief description of the current DL techniques that are used by researchers in this field. After that, this study lists some of the commonly used datasets. This is followed by a performance comparison of these reviewed methods with respect to some commonly used metrics in computer...

Enhancement of Diabetic Retinopathy Prognostication Using Deep Learning, CLAHE, and ESRGAN

Diagnostics

One of the primary causes of blindness in the diabetic population is diabetic retinopathy (DR). Many people could have their sight saved if only DR were detected and treated in time. Numerous Deep Learning (DL)-based methods have been presented to improve human analysis. Using a DL model with three scenarios, this research classified DR and its severity stages from fundus images using the “APTOS 2019 Blindness Detection” dataset. Following the adoption of the DL model, augmentation methods were implemented to generate a balanced dataset with consistent input parameters across all test scenarios. As a last step in the categorization process, the DenseNet-121 model was employed. Several methods, including Enhanced Super-resolution Generative Adversarial Networks (ESRGAN), Histogram Equalization (HIST), and Contrast Limited Adaptive HIST (CLAHE), have been used to enhance image quality in a variety of contexts. The suggested model detected the DR across all five APTOS 2019 grading proc...