Segurança do paciente: interações medicamentosas em pacientes adultos internados/Patient safety: drug interactions in adulted patients (original) (raw)
Related papers
2021
Introduction: older patients usually had multiple diseases and so use many medicines. The elevated risks of pharmacotherapy in this population justified the development of ratings for unsafe medicines. Objective: to estimate the prevalence of potential drug interactions of clinical importance in primary health care and its associated factors, improving prescription practices and increasing patient safety. Methods: a cross-sectional study of dependent variable "number of potential drug-drug interactions of clinical importance", in all medicines and patients who accessed medicines via public primary health care, 2013. The independent variables were socio demographic, accessibility of health services and pharmacotherapy. Multivariate analyses were performed using the Statistical Learning Theory with Exaustive-CHAID algorithm, with test Pearson's chi-square adjusted by the Bonferroni method. Results: a total of 4,037 patients were included in this study and the patient prevalence of at least one drug-drug interaction was 36.5% with severity moderate (66.2%) or major (28.5%). The most prevalent conduct for management of them were monitor the patient (59.0%), adjust the dosage of the medicines (21.9%) and monitoring signs and symptoms (16.7%). In the multivariate analysis by the Theory of Statistical Learning when we compared the "patients who had at least one drug interaction of clinical importance" with those who did not have them at the first hierarchical level of relevance, the variable "number of drugs in use" prevailed with a p value <0.0001. The analysis also proposed 7 different risk strata to explain the distinction between having at least one interaction of clinical importance, namely: 1, 2, 3, 4, 5, 6-7 and> 8 drugs. When comparing patients with 2 medications and those with 8 or more medications, the prevalence of drug interactions increases by about 80%. Using polypharmacy (5 or more drugs) as the cutoff point to make the same comparison, the increase is about 45%. Other variables with statistical relevance to explain having or not having hair were "multiple drug dispensations per month" (p = 0.003 and p = 0.01) and "being elderly" (p = 0.003). Having "multiple drug dispensations per month" reduced the prevalence of interactions by about 10% for both patients with 3 medications (p = 0.003) and those with 6 or 7 medications. Conclusions: the drug-drug interactions showed be different in primary care of hospitals and other place for health care. And the number of medications in use by the patient seems to be the main marker for patient selection for this type of analysis, with polypharmacy being a relevant cutoff point, but above all the use of 8 or more medications indicates a prevalence of more than 90% patients of at least one interaction of clinical importance. There are few studies of potential drug-drug interactions in public primary health care, especially with analysis of the severity and management of them. We recommend more studies for clarify prevalence, types and associated factors.
Potential drug-drug interactions in a Brazilian teaching hospital: age-related differences?
Journal of Basic and Applied Pharmaceutical Sciencies, 2016
This study proposes to measure frequency and to characterize the profile of potential drug interactions (pDDI) in a general medicine ward of a teaching hospital. Data about identification and clinical status of patients were extracted from medical records between March to August 2006. The occurrence of pDDI was analyzed using the database monographs Micromedex® DrugReax® System. From 5,336 prescriptions with two or more drugs, 3,097 (58.0%) contained pDDI. The frequency of major and well document pDDI was 26.5%. Among 647 patients, 432 (66.8%) were exposed to at least one pDDI and 283 (43.7%) to major pDDI. The multivariate analysis identified that factors related to higher rates of major pDDI were the same age (p< 0.0001), length of stay (p< 0.0001), prevalence of hypertension [OR=3.42 (p< 0.0001)] and diabetes mellitus [OR=2.1 (p< 0.0001)], cardiovascular diseases (p< 0.0001) and the number of prescribed drugs (Spearman’s correlation=0.640622, p< 0.0001). Between...
Patient Safety: Drug Interactions in Adulted Patients
2020
Objective: to investigate evidence in the literature about interactions arising from drug prescriptions of hospitalized adult patients. Method: this is an integrative literature review carried out through six steps. Data collection took place in July 2020, in the BDENF, LILACS via BVS, CINAHL, SCOPUS, Web of Science via Capes Periodicals Portal and SciELO databases, using the descriptors drug interactions, drug prescriptions and patient safety. Eighteen productions were selected in the time frame from 2008 to 2020. Results: of the articles selected, ten were national and eight international studies. Intensive care and emergency units were the most investigated scenarios. The results were categorized into three thematic axes: prescriptions and drug interactions; scheduling and drug interactions; interventions and drug interactions. Conclusion: drug interactions occur at high rates, mainly in cases of drug prescriptions associated with polypharmacy and in critical units. Interventions...
A pharmacoepidemiologic study of drug interactions in a Brazilian teaching hospital
Clinics, 2006
PURPOSE: Although drug-drug interactions constitute only a small proportion of adverse drug reactions, they are often predictable and therefore avoidable or manageable. There are few studies on drug-drug interactions from Brazil. This study aimed to assess the frequency of drug-drug interactions in prescriptions and their potential clinical significance in patients of a Brazilian teaching hospital. METHODS: From January to April 2004, a sample of 1785 drug prescriptions was drawn from a total of 11,250. Drug-drug interactions were identified by using Micromedex ® DrugReax ® System. Patients´ records with major drug-drug interactions were reviewed by a pharmacist and a medical doctor looking for signs, symptoms, and lab tests that could indicate adverse drug reactions due to such interactions. RESULTS: From the 1785 prescriptions examined, 1089 (61%) were from the male adult ward. Patients' average age was 52.7 years (SD = 18.9; range, 12-98). The median number of drugs in each prescription was 7 (range, 2-26). At least 1 drug-drug interactions was present in 887 (49.7%) prescriptions. Regarding the severity of the clinical result, the interactions were classified as minor (20; 2.3%), moderate (184; 20.7%), major (30; 3.4%), and undetermined because of an incidence of more than 1 interaction in a single patient (653; 73.6%). From the 30 patients with major interactions, 17 (56.7%) presented adverse drug reactions induced by exposure to a major drug-drug interaction. CONCLUSIONS: Patients did suffer adverse drug reactions from major drug-drug interactions. Many physicians may be unaware of drug-drug interactions. Education, computerized prescribing systems and drug information, collaborative drug selection, and pharmaceutical care are strongly encouraged for physicians and pharmacists.
2006
Cruciol-Souza JM, Thomson JC. A pharmacoepidemiologic study of drug interactions in a brazilian teaching hospital. Clinics. 2006;61(6):515-20. PURPOSE: Although drug-drug interactions constitute only a small proportion of adverse drug reactions, they are often predictable and therefore avoidable or manageable. There are few studies on drug-drug interactions from Brazil. This study aimed to assess the frequency of drug-drug interactions in prescriptions and their potential clinical significance in patients of a Brazilian teaching hospital. METHODS: From January to April 2004, a sample of 1785 drug prescriptions was drawn from a total of 11,250. Drug-drug interactions were identified by using Micromedex ® DrugReax ® System. Patients ´ records with major drug-drug interactions were reviewed by a pharmacist and a medical doctor looking for signs, symptoms, and lab tests that could indicate adverse drug reactions due to such interactions. RESULTS: From the 1785 prescriptions examined, 10...
Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 2019
The risk of drug interaction (DI), especially in the hospital setting, increases along with the number of drugs used by the patient. Studies that evaluate drug interactions based on patient prescriptions are therefore useful to know this risk and guide strategies to improve drug use. The present study is aimed to identify studies that evaluated DI in patients of Brazilian hospitals. As of bibliographic search in several databases, we collected articles describing prescribing evaluations which focused on the analysis and identification of drug interactions in Brazilian hospitals. The search was conducted in 2017 and there was no restriction of publication time. Of a total of 273 articles retrieved, 23 were included for analysis. Most was published after 2010, and the predominant design was cross-sectional studies. The Micromedex® database was the most used to categorize the interactions, and midazolam and fentanyl was the most commonly reported potential DI in the studies. The result...
Potential drug interactions and inappropriate medications prescribed for primary health care users
Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 2020
Objectives: To analyze potential pharmacological interactions and drugs potentially inappropriate for the elderly in users of primary care of the Unified Health System. Methods: This is a cross-sectional study with individuals aged 18 years or over, who were approached at the health facilities of the city of Divinópolis, MG, at which time a home visit was scheduled. A structured questionnaire on drug use was applied and drug interactions were analyzed in Drugs.com® sources, Micromedex®, bulletin of the Brazilian Health Regulatory Agency (ANVISA). Only the frequencies of serious interactions were analyzed. Potentially inappropriate drugs for elderly people (MPI) were identified by the Beers Criterion (2015) and the Brazilian Consensus on Potentially Inappropriate Medications for the Elderly (2016). The Mann-Whitney test was performed to compare the medians of the analyzed variables. Results: Among the study participants, 55% were elderly. Comparing them with the adult population, it ...
Prevalência de potenciais interações medicamentosas droga-droga em unidades de terapia intensiva
Revista Brasileira de Terapia Intensiva, 2008
Potential drug interactions prevalence in intensive care units Prevalência de potenciais interações medicamentosas droga-droga em unidades de terapia intensiva ORIGINAL ARTICLE INTRODUCTION A drug interaction takes place when the effects and/or toxicity of a drug are affected by another drug. (1,2) Although results may be positive (increased efficacy) or negative (decrease of efficacy, toxicity or idiosyncrasy), in pharmacotherapy they are usually unforeseen and undesirable. (3) With the continued development of new drugs and subsequent prescriptions with increasingly more complex combinations it has become difficult for physicians and pharmaceutics to be familiar with all potential interactions. (4) Risk of occurrence and severity rest upon several factors, among them
Ciência, Cuidado e Saúde, 2020
Objetivo: investigar na literatura evidências sobre interações advindas de prescrições de medicamentos de pacientes adultos internados. Método: Trata-se de uma revisão integrativa da literatura, realizada por meio de seis etapas. A coleta de dados ocorreu em julho de 2020, nas bases de dados da BDENF, LILACS via BVS, CINAHL, SCOPUS, Web of Science via Portal Periódicos Capes e SciELO, com os descritores drug interactions, drug prescriptions e patient safety. Selecionaram-se 18 produções no recorte temporal de 2008 a 2020. Resultados: dos artigos selecionados, dez eram estudos nacionais e oito internacionais. As unidades de terapia intensiva e emergência foram os cenários mais investigados. Os resultados foram categorizados em três eixos temáticos: prescrições e interações medicamentosas; aprazamento e interações medicamentosas; intervenções e interações medicamentosas. Conclusão: as interações medicamentosas possuem altas taxas, principalmente nas prescrições medicamentosas com poli...