Angiolymphoid hyperplasia with eosinophilia on the leg successfully treated with T-helper cell 2 cytokine inhibitor suplatast tosilate (original) (raw)
Related papers
Angiolymphoid hyperplasia with eosinophilia: a case report
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, reactive vaso-proliferative disease, presenting with painless, vascular nodules in the dermal and subcutaneous tissues, sually seen in the head and neck region. It is characterized clinically by single to multiple red brown dome shaped papules or subcutaneous nodules. Its etiology is unknown and the histology is characterized by hyperplastic blood vessels lined by a hypertrophic endothelium with an inflammatory infiltrate rich in eosinophils. We report three cases of ALHE presenting over the ears and scalp.
International Journal of Otorhinolaryngology and Head and Neck Surgery
Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura’s disease are uncommon chronic benign lesions of the skin mainly involving the head and neck regions where ALHE involves vascular and lymphocytic proliferation and Kimura’s is of inflammatory type. Dermal involvement is more in ALHE but In Kimura’s disease the lymphnodes and subcutaneous tissues are involved more. ALHE is a rare vascular tumor and Kimura’s disease is a chronic inflammatory disease. Both not only have uncertainty in etiology and pathogenesis, but also there is therapeutic dilemma in management. In this article, we describe a case of ALHE which presented to our ENT outpatient department with swelling in the left postauricular region which appeared 1.5 years back and posed a riddle in coming to correct diagnosis. On examination, a single smooth spherical swelling in upper part of post-auricular region of size 3×3 cm with well-defined edges and normal skin. Blood investigations revealed elevated absolute eosi...
A rare case of angiolymphoid hyperplasia with eosinophilia in the submental region
Journal of Oral and Maxillofacial Pathology, 2013
Angiolymphoid hyperplasia with eosinophilia is a rare reactive, angio-proliferative lesion which is usually found in the subcutaneous tissue of the head and neck. The lesion rarely arises from a native blood vessel. It is of unknown etiology but may be related to some benign, localized form of vasculitis. While preauricular location is the most frequent site of occurrence as reported in literature, a lesion in submental region seems to be a first reported site of occurrence. We report such an occurrence in an individual with history of trauma twice in his lifetime at the affected site. Spontaneous regression is common, but persistent or recurrent lesions may require treatment. Several treatments have been reported but surgery is considered to be the most efficient one.
Anais Brasileiros de Dermatologia
Angiolymphoid hyperplasia with eosinophilia is a rare and benign vascular tumor whose etiology remains uncertain. It clinically presents itself by angiomatous papules or nodules located on the head and neck. Many controversies in the literature are found in relation to angiolymphoid hyperplasia with eosinophilia and Kimura's disease-its main differential diagnosis-due to their clinical and histopathological similarities. However, currently, most studies agree that they are distinct diseases. The present case illustrates a characteristic description of angiolymphoid hyperplasia with eosinophilia and also highlights the main differences with Kimura's disease.
Angiolymphoid hyperplasia with eosinophilia: improvement in a recurrent case with isotretinoin
Journal of Pakistan Association of Dermatology, 2016
Angiolymphoid hyperplasia with eosinophilia (ALHE), characterized by dermal and subcutaneous nodules in head and neck areas, is often very disfiguring. There are different modalities of treatment but surgery seems to be the best. We report a 31-year-old man with recurrent ALHE showing considerable improvement with isotretinoin.
Giant angiolymphoid hyperplasia with eosinophilia on the chest
Journal of Cutaneous Pathology, 2009
Giant angiolymphoid hyperplasia with eosinophilia on the chest Angiolymphoid hyperplasia with eosinophilia is a rare vascular proliferation characterized by single or multiple purplish, brownish papules and subcutaneous nodules, sometimes associated with pain or pruritus. This rare benign process occurs with a female predominance. Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp. Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear. Histopathologically, the lesions consist of a proliferation of blood vessels of variable size lined by large epithelioid endothelial cells and a variable inflammatory infiltrate of lymphocytes and eosinophils, sometimes with lymphoid follicle formation. The lesion is benign but may be persistent and is difficult to eradicate. We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest. We emphasize this case considering the unusual dimensions of the lesion (8 cm diameter) and the atypical location on the chest.
Angiolymphoid hyperplasia with eosinophilia is a benign vasculo-prolifera-tive disease, predominantly found in middle-aged women (20-50 years old) and with exceptionally cases reported in children or elderly. We report the case of a male patient who developed multiple lesions of angiolymphoid hyperplasia with eosinophilia in the seventh decade of life. A 63-year-old man, without pathological antecedents presents with 6 nodular reddish le-sions, 2-4 mm in size, moderately itchy, located in the left retroauricular region. Based on anamnesis, clinical examination, histopathological exam and other laboratory tests, we established the diagnosis of Angiolymphoid hyperplasia with eosinophilia. After complete excision, immediate repair of the defect was performed using advancement flaps from the declive aria. After a 9-months follow-up there was no evidence of recurrence. Considering the possible internal organ involvement, we recommend a quarterly follow-up of the patient for an early diagnosis of other pathological conditions that can lead to a poor vital prognosis.