Perioperative Respiratory Outcome of Patients with Eosinophilia: A Cohort Study in a Tertiary Care Hospital (original) (raw)
Related papers
2015
This prospective observational study was formed to perioperative respiratory complications in 200 paediatric patients of 3 a period of one year. Preoperatively AEC was measured. Patients with patients received uniform anaesthesia by a single paediatric anaesthesiologist. Respiratory complications such as cough, stridor, bronchospasm, laryngospasm, pulmonary oedema were studied in each group. The rate complications was proportionately increased with the rise of AEC irrespective of age, sex, weight of the patients. Complications were treated with appropriate measures and drugs. Other non studied This prospective observational study was formed to identify the association of absolute eosinophil count (AEC) and perioperative respiratory complications in 200 paediatric patients of 3 < 5 years receiving elective general anaesthesia over a period of one year. Preoperatively AEC was measured. Patients with AEC 0< 800 were studied in three groups. All patients received uniform anaesthes...
Immunopathologia Persa
Introduction: Wheezing episodes are common in infants, younger, and older children which are most commonly caused by asthma or viral bronchiolitis. Objectives: This study aims to determine the possible correlation between blood eosinophil count and responsiveness to bronchodilators in pediatric patients admitted for wheezing episodes. Patients and Methods: This cross-sectional study was conducted on 98 patients aged between one month to 12 years (a mean of 2.53 ± 1.12 years) that were admitted because of wheezing at two university hospitals of Jundishapur university of medical sciences, Ahvaz, Iran. The severity of wheezing was defined according to the Preschool Respiratory Assessment Measure (PRAM) classification. The peripheral blood eosinophil count was checked as part of the complete blood count (CBC) in all patients before treatment initiation. Then, the peripheral blood eosinophil count was compared between the two groups of patients based on showing significant or no signific...
Pakistan Journal of Medical and Health Sciences
Objective: To determine the frequency of eosinophilia in patients presenting with acute exacerbation chronic obstructive pulmonary disease (AECOPD). Patients and Methods: A total number 217 patients presenting with AECOPD were included from August-2021 to March-2022. Data regarding patients age, gender, diabetes, hypertension, smoking and duration of COPD was collected for each patient. After inclusion, venous blood samples were taken and were analyzed for presence of eosinophilia. Results: Mean age of patients was 59.32±8.92 years. Mean duration of COPD was 6.56±2.49 years. There were 127 (74.7%) male and 43 (25.3%) female patients. Out of 170, 121 (71.2%) patients were smokers, 66 (38.8%) diabetic and 79 (46.5%) hypertensive patients. Eosinophilia was diagnosed in 37 (21.8%) patients. Conclusion: Based on the data of our study including 170 patients hospitalized for AECOPD, we found that 21.8% patients had blood eosinophilia (defined as ≥300 cells/μL). So Peripheral blood eosinoph...
2022
Background: Present study aimed to evaluate the association between blood eosinophil count and tissue eosinophil grading among Patients suffering from Sinonasal Polyposis attending routine ENT OPD in Dr. RPGMC Tanda. Material & Methods: The present study was done as a hospital based cross sectional study in the department of ENT & Head and Neck Surgery, in Dr. RPGMC Kangra at Tanda. It was done in 30 patients of chronic rhinosinusitis with nasal polyposis (CRSwNP) from June 2018 to June 2019 who met the inclusion criteria. Data regarding Blood & Tissue eosinophil count was retrieved. Results: in the present study,there were a total of 30 patients out of which there were 16 males and 14 females. The mean age observed of patients was 42.47±13.68. Among the total, 17 patients were classified as Eosinophilic Chronic Rhinosinusitis with Nasal Polyposis (ECRSwNP) while 13 were classified as Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyposis (NECRSwNP). There were 9 cases of ECRSwNP where tissue eosinophils were >10/HPF while 8 cases had <10 tissue eosinophils/HPF. Similarly 9 cases of NECRSwNP had <10 tissue eosinophils/HPF while 4 cases had tissue eosinophils were >10/HPF. The association between blood eosinophil count and tissue eosinophil grading was not significant with p value of 0.225. Conclusion: Present study concluded that there was no significant association of blood eosinophil count between NECRSwNP and ECRSwNP with tissue eosinophils.
Low and High Blood Eosinophil Counts as Biomarkers in Hospitalized Acute Exacerbations of COPD
Chest, 2019
BACKGROUND: Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict beneficial responses to these therapies. METHODS: We conducted derivation (n ¼ 242) and validation (n ¼ 99) cohort studies of patients hospitalized for AECOPD. Patients who received oral corticosteroids before ED presentation were excluded. The derivation cohort was identified by individual case file review. The validation cohort was prospectively recruited during hospital admission. Exacerbations were grouped according to blood eosinophil count as low (<50/mL), normal (50-150/mL), or high (>150/mL). Exacerbations were classified as being associated with infection if either virus testing was positive or C-reactive protein was $20 mg/L. Associations of eosinophil groups with infection, hospital length of stay, and 12-month survival were compared using appropriate statistical methods. RESULTS: There were no significant differences in baseline characteristics between patients with low, normal, or high blood eosinophils in either cohort. Eosinophil counts <50/mL were more strongly associated with infection (91% vs 51.9%, P ¼ .001), distinguished patients with longer median hospital stays (7 vs 4 days, P < .001), and were associated with lower 12-month survival (82.4% vs 90.7%, P ¼ .028; pooled data of both cohorts) than eosinophil counts >150/mL. CONCLUSIONS: Low and high blood eosinophil counts in hospitalized patients with AECOPD provide a practical clinical distinction that can potentially be used to inform management strategies. Prospective studies are needed to evaluate if this strategy can guide discriminate use of antibiotics and/or corticosteroids.
Airway and esophageal eosinophils in children with severe uncontrolled asthma
Pediatric Pulmonology, 2018
Aim: Children with severe uncontrolled asthma (SUA) have a high burden of symptoms and increased frequency of asthma exacerbations. Reflux esophagitis and eosinophilic esophagitis are important co-morbid factors for SUA. Both are associated with the presence of eosinophils in esophageal mucosa. We hypothesized that esophageal eosinophils are frequently present and correlate with the presence of airway eosinophils in children with SUA. Method: We performed a retrospective analysis of a prospective database of children who underwent "triple endoscopy" (sleep laryngoscopy, bronchoscopy with bronchoalveolar lavage [BAL] and endobronchial biopsy [EBB], and esophagogastroduodenoscopy with esophageal biopsy [EsB]) at our Aerodigestive Center for evaluation of SUA. Children with known cystic fibrosis, primary ciliary dyskinesia, and aspirationrelated lung disease were excluded. Result: Twenty-four children (21 males) ages 2-16 years were studied. Elevated BAL eosinophils were found in 10 (42%) patients, endobronchial eosinophils in 16 (67%); 7 (29%) had endobronchial eosinophils without elevated BAL eosinophils. Esophageal eosinophils were found in 11 (46%) patients. There was a correlation between the amount of eosinophils in BAL and EBB (R = 0.43, P = 0.05) airway eosinophils, defined as elevated BAL and/or EBB eosinophils, correlated with esophageal eosinophils (R = 0.41, P = 0.047). Conclusion: We concluded that airway and esophageal eosinophils are frequently present in children with SUA.
Eosinophilic Lung Disease: Accompanied with 12 Cases
Turkish Thoracic Journal/Türk Toraks Dergisi, 2015
Eosinophilic lung diseases are a rare group of heterogeneous diseases characterized by the increase of the eosinophil ratio in airways and lung parenchyma. In our clinic, patients diagnosed with eosinophilic lung disease were evaluated with their clinical features and prognoses. MATERIAL AND METHODS: In our clinic, 12 cases that were diagnosed and followed up for eosinophilic lung disease [eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) (n=4), chronic eosinophilic pneumonia (CEP) (n=7), and simple pulmonary eosinophilia (Löffler's syndrome) (n=1)] were retrospectively evaluated. RESULTS: Of the 12 cases, 8 were females, and the average age was 43 (28-72) years. All cases were undergoing bronchodilator therapy with asthma diagnosis (2 months-40 years). Additionally, 4 of the cases had sinusitis, and 1 had allergic rhinitis. The most common complaints of the patients were difficulty in breathing and coughing, and the duration of complaints was a median of 2 months. Peripheral eosinophilia and total IgE elevation were present during the admission of all cases; additionally, leucocyte elevation was recorded in 10 of them, anemia in 4 of them, and thrombocytosis in 4 of them. Moreover, 43% of the recorded DLCO values were lower than normal. Of the 10 cases that underwent bronchoalveolar lavage (BAL), the eosinophil ratio was above 25% in 7 subjects. Of the 8 cases that underwent transbronchial biopsy, eosinophil-involving infiltration was detected in 6 subjects. Additional findings in cases diagnosed with EGPA were nasal polyposis (n=1), sinusitis (n=2), polyneuropathy (n=1), cardiac involvement (n=2), and skin involvement in biopsy (n=1). Spontaneous recovery was observed in the patient diagnosed with simple pulmonary eosinophilia during the follow-up that was performed based on the history and laboratory and BAL results of the patient. Prednisolone treatment was started for all cases, except for simple pulmonary eosinophilia, and their controls were performed. Relapse was observed in eight cases (EGPA: 4, CEP: 4); during the relapse treatment of one case diagnosed with EGPA, exitus occurred. One case rejected treatment despite the presence of peripheral eosinophilia, and the other cases are being followed-up without medication. CONCLUSION: Given that the clinical pictures in pulmonary eosinophilia syndromes are on a wide spectrum, a specific diagnosis is important. Progression may differ in each patient, and a close follow-up is necessary during and after the treatment.
Introduction; An exacerbation of COPD is defined as an acute worsening of respiratory symptoms that results in additional therapy. COPD has eosinophilic airway inflammation both in a stable state and during exacerbations Although the eosinophil threshold associated with clinical relevance in patients with COPD is currently subject to debate, eosinophil counts hold potential as biomarkers to guide therapy. Aims and objectives; To estimate absolute blood eosinophil count and its correlation with in hospital length of stay in COPD-AE. Materials and methods; Pre-treatment laboratory complete blood count with differential, absolute eosinophil count were sent. Pre-treatment absolute blood eosinophil counts analyzed for its association with in hospital length of stay in COPD acute exacerbation. Results & Discussion; Among 50 cases 80% cases are males and 20% cases are females. Maximum number of cases (18) fell between 61-70 years of age., patients with absolute eosinophil count less than 300 cells/μl stayed in the hospital for a longer period of time as compared to patients exhibiting a higher eosinophil count at the time of admission. Conclusion; The patients with low absolute blood eosinophil counts have longer length of stay compared to high blood absolute eosinophil counts.