Triterpenes and polyphenols from Anogeissus leiocarpus (Combretaceae (original) (raw)
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Antioxidants
Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) has a long history of use by folk populations for the management of multiple human ailments. Based on the published literature, there has been no attempt to conduct a comparative assessment of the biological activity and the phytochemical profiles of the leaves and stem bark of A. leiocarpus extracted using methanol, ethyl acetate, and water. By high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) analysis, quinic, shikimic, gallic, and protocatechuic acids were tentatively identified from all the extracts, while chlorogenic, caffeic, ferulic, and dodecanedioic acids were only characterised from the leaves extracts. Additionally, a pharmacological study was carried out to evaluate potential protective effects that are induced by the extracts in rat colon and colon cancer HCT116 cell line. In general, the methanol and water extracts of A. leiocarpus leaves and stem bar...
Flavonoids and Tannins from Anogeissus latifolia
Azhar International Journal of Pharmaceutical and Medical Sciences (Print), 2023
Anogeissus latifolia (Roxb. ex DC), Family Combretaceae, is considered as one of the most useful trees in India as the main source of the commercial Indian gum, known as ghatti gum and used for tanning processes. In traditional medicine it is reported for the treatment of many diseases like UTI infections, cardiac disorder and liver complaints and proved to have a wide range of biological activities due to its high content of tannins, appreciable quantities of flavonoids, terpenes and saponins.Two dimensional paper chromatography investigation of the 70% aqueous methanol leaf extract revealed the presence of high polyphenolic contents of versatile structures. This study describes the chromatographic isolation and identification of four flavonoids and three tannins metabolites for the first time from the leaf and stem methanol-soluble portions. Their structures were established as vitexin, isovitexin, isoorientin, orientin, gallagic acid bilactone (terminalin), puncalin and 2-O-galloylpunicalin based on the chromatographic properties, spectroscopic analyses (1 H and 13 C NMR) and HRESI-MS.
Steriod and Triterpenoid from Anogeissus latifolia
Dhaka University Journal of Pharmaceutical Sciences, 2007
3-?-hydroxy-28-acetyltaraxaren (1) and ?-sitosterol (2) were isolated from an ethyl acetate extract of the stem bark of Anogeissus latifolia. The ethyl acetate and methanol extracts when subjected to antimicrobial screening showed significant inhibitory activity to microbial growth, while the ethyl acetate showed demonstrated significant cytotoxicity to brine shrimp with LC50 of 0.50 ?g/ml. Key words: Anogeissus latifolia, Combretaceae, 3-?-hydroxy-28-acetyltaraxaren, ?-sitosterol, antimicrobial, cytotoxiciy, disc diffusion Dhaka Univ. J. Pharm. Sci. 6(1): 47-50, 2007 (June) The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
2018
Many diseases such as malaria, high blood pressure, infertility, diabetes, cancer, etc., have a genesis linked to oxidative stress caused mainly by the excess of free radicals in the body. The objective of this work is to evaluate the biochemical activities of aqueous extracts of leaves and trunk bark of Anogeissus leiocarpus (DC) Guill. And Perr. (Combretaceae), a medicinal plant of the Ivorian flora. For this purpose, dosages of phytoconstituents, the antioxidant activity as well as the phytochemical screening of these organs are carried out. Antioxidant activity is evaluated by DPPH and ABTS tests. Quantitative studies of phytoconstituants revealed that the leaves contained a high content of total phenolic compounds (12986.46 ± 0.31 μg / g) in relation to trunk bark (10718.89 ± 0.21 μg / g). The mean total flavonoid content was 1555.82 μg / g for the leaves and 525.54 μg / g for the trunk bark. The lowest IC50 (19.8 μg / mL) is also obtained with the leaves. In addition, phytoche...
New Triterpene Glycosides from the Stems of Anomospermum grandifolium
Journal of Natural Products, 2003
Two new dammarane saponins identified as jujubogenin 3-OR -L-arabinofuranosyl(1f2)-[-D-glucopyranosyl(1f6)-D-glucopyranosyl(1f3)]-R-L-arabinopyranoside (2) and jujubogenin 3-OR -L-arabinofuranosyl-(1f2)-{6-O-[3-hydroxy-3-methylglutaryl]-D-glucopyranosyl(1f3)}-R-L-arabinopyranoside (3) and a new lupane saponin, 3-hydroxylup-20(29)-en-27,28-dioic acid 28-O-D-glucopyranosyl(1f2)-[-D-xylopyranosyl(1f3)]-D-xylopyranosyl(1f2)-D-glucopyranoside ester (5), along with the known jujubogenin 3-OR -L-arabinofuranosyl(1f2)-[-D-glucopyranosyl(1f3)]-R-L-arabinopyranoside (1) and 3-hydroxylup-20(29)ene-27,28-dioic acid (4), were isolated from the methanol extract of the stems of Anomospermum grandifolium. The structures of the new compounds were established by spectral analysis. Antimicrobial activity screening of compounds 1-3 revealed antifungal properties against C. albicans ATCC 3153 for compounds 2 and 3. The antibacterial and antifungal activities of the petroleum ether, chloroform, and methanol extracts of A. grandifolium stems were also evaluated.
Antiulcer and antimicrobial activity of Anogeissus latifolia
Journal of Ethnopharmacology, 2006
Ethnobotanically, the bark of Anogeissus latifolia (Roxb. ex DC.) Wall. ex Guill. & Perr.(Combretaceae) has been reported to be used in the treatment of various disorders including stomach and skin diseases. We studied the antiulcer potential and antimicrobial activity of the 50% aqueous alcoholic extract in order to validate ethnobotanical claims regarding the plant use in the above-mentioned disorders. Gastroprotective potential of the Anogeissus latifolia extract (ALE) (100 and 200 mg/kg/body weight) was studied on aspirin, cold-resistant stress (CRS), pylorus ligated (PL) and ethanol-induced ulcers. Status of the antioxidant enzymes superoxide dismutase (SOD) and catalase along with lipid peroxidation (LPO) was also studied in CRS-induced ulcers. The results of the present study showed for the first time that the ALE possessed gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by physical and chemical agents with a maximum of 84.16% curation (200 mg/kg body weight) in CRS-induced ulcers. ALE decreased LPO and SOD with concomitant increase in catalase activity in CRS-induced ulcers. Moderate antibacterial activity and antifungal activity was also observed. High performance thin layer chromatography (HPTLC) showed the presence of gallic acid and ellagic acid (0.95%, w/w, 0.25%, w/w, respectively) in the plant. These findings could justify, at least partially, the inclusion of this plant in the management of gastric disorders in traditional medicine.
FUDMA JOURNAL OF SCIENCES
Preliminary characterization of phytocompounds from stem bark of Anogeissusleiocarpus and its antimicrobial effects was carried out in this study. Concentrated and dried extracts obtained, after extraction of the plant material, were subjected to phytochemical screening and FT-IR analysis. Part of extracts obtained were used for antimicrobial studies on eleven pathogenic clinical isolates namely Methicillin resistant Staphylococcusaureus, Vancomycin resistant enterococci, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Salmonella typhi, Candida krusei, Candida albicans and Candida stellatoidea using standard protocols. Phytochemical screening of the plant extracts revealed the presence of, alkaloids, steroids, saponins, tannins, flavonoids and reducing sugars. FT-IR's spectroscopic analysis showed characteristic peaks of alcohols, ethers, esters, carboxylic acids, aldehydes, ketones and amines groups matching with some of...
Pentacyclic triterpenes from the stem bark of Combretum hartmannianum Schweinf
Biochemical Systematics and Ecology, 2018
Chemical investigation of the stem bark of Combretum hartmannianum Schweinf (Combretaceae) led to the isolation and identification of nine compounds with pentacyclic triterpene skeletons. These were identified as three ursane-type triterpenes, ursolic acid (1), pomolic acid (2), and corosolic acid (3); one oleanane-type triterpene, arjunic acid (4); and five oleanane-type triterpene glucosides, arjunglucoside I (5), trachelosperoside E-1 (6), combreglucoside (7), chebuloside II (8), and 2a,3b,6b,19a-tetrahydroxyoleanolic acid 28-O-b-D-glucopyranoside (9). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. This is the first report of triterpene compounds from a species of C. hartmannianum and the first report of compounds 2 and 9 from a member of the Combretaceae family.