New Hydrazyl Derivatives with Multiple Properties (original) (raw)
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Synthesis and reactions of some novel 1-(2,7-dimethyl-1,8-naphthyridin-4-yl)hydrazine candidates
Russian Journal of General Chemistry, 2017
A series of novel 1,8-naphthyridine derivatives containing Schiff bases and amino substituents were synthesized starting from the reaction of 4-hydrazinyl-2,7-dimethyl-1,8-naphthyridine with different active carbonyl groups, acid monoanhydrides and tetracarboxylic acid anhydrides. Structures of new compounds were elucidated by means of physical and spectroscopic analyses.
Synthesis and Characterization of Some Hydrazinederivatives with Α, Β Unsaturated Acids
Kongunadu Research Journal, 2015
Metal cinnamate monohydrazinates of the formula M(cin)2N2H4, where M= Co or Zn, nickel crotante monohydrazinate monohydrate Ni(crot)2N2H4.H2O, metal cinnamate and crotonate dihydrazinates M(cin)2(N2H4)2 Where M = Co, Ni, Zn or Cd , M(crot)2(N2H4)2 Where M = Co or Ni and cadmium crotante dihydrazinate monohydrate Cd(crot)2(N2H4)2.H2O have been prepared and characterized by spectral, thermal and X-ray diffraction studies. Electronic spectra indicate that the cobalt and nickel complexes are high-spin octahedral complexes. The IR data show that the binding of hydrazine and the unsaturated carboxylate anion to the metal ion is bidentate. TG-DTA studies show that metal complexes undergo decomposition through metal carboxylate intermediate to give respective metal oxide as the final product. Xray powder diffraction patterns of the complexes indicate isomorphism among them.
Novel Synthesis of Some New Hydrazide-Hydrazones Containing Benzilic Acid Unit
A series of new hydrazones, namely of 2-hydroxy-2,2-diphenyl-N-(aryl methylene) aceto hydrazide (4a-g) and 2-hydroxy-N(1-alkylalkyllidene)-2,2-diphenyl aceto hydrazide (5a-f) derivatives were synthesized by the reaction of benzilic acid hydrazide (3) with substituted aromatic aldehydes and substituted ketones respectively. The synthesized hydrazones were characterized on the bases of their physical properties and spectroscopic data. Some of these compounds were tested for biological activities as antibacterial and antifungal agents and showed a significance to moderate activity.
A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines
Istanbul university journal of pharmacy, 2019
This report is about an unexpected formation of N,N'-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N'-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N'-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N'-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N'-bis(substituted phenoxyacetyl) hydrazine derivatives.
Rafidain Journal of Science
The N-(4-methyl-2-pyridyl)anthranilic acid (I) was synthesized by Ullmann condensation. The compound (I) was cyclized by polyphosphoric acid (PPA) to give 4-methyl-10Hbenzo[b][1,8]naphthyridin-5-one (II). The compound (II) was treated with selenium dioxide (SeO 2) and thionyl chloride (SOCl 2) to give the 4-formyl-10H-benzo[b][1,8]naphthyridin-5-one (III) and 4methyl-5-chloro-benzo[b][1,8]naphthyridine (IV) respectively.The compound (III) was reacted with various substituted anilines and aliphatic amines to give the Schiff bases (Va-j). The compound (IV) was reacted with hydrazine hydrate to yield the 5-hydrazino derivative (VI), which was reacted with various aromatic aldehydes to yield the hydrazones (VIIa-j) and the R f values reported.The reaction progress was followed by thin layer chromatography (TLC). The synthesized compounds were confirmed by spectral data (I.R, 1 H-NMR, 13 C-MNR). The possible fragmentation pattern of GC/MS for the compounds (III), (Vc) and (VIIg) were reported.
Australian Journal of Chemistry, 2007
Starting from the well known stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH; 2a) and its congener 2,2-diphenyl-1-(4-cyano-2,6-dinitrophenyl)hydrazyl 2b, or from their reduced hydrazine counterparts 1a,b, it was possible to obtain the p-quinonoid compounds 4a,b by oxidation with ceric (Ce4+) sulfate, which by reduction gave the corresponding hydroxyl derivatives 2-phenyl-2-(4-hydroxyphenyl)-1-picrylhydrazine 5a or 2-phenyl-2-(4-hydroxyphenyl)-1-(4-cyano-2,6-dinitrophenyl)hydrazine 5b. These hydroxyl derivatives (5a,b) react with 4-carboxy-TEMPO or 2,2-diphenyl-1-(4-carboxy-2,6-dinitrophenyl)hydrazine to form the corresponding esters 6a,b or 8a,b. These esters (6a,b and 8a,b) lead to the hybrid hetero diradicals (nitroxide–hydrazyl type) 7a,b or homo biradicals (hydrazyl–hydrazyl type) 9a,b by oxidation with lead dioxide or potassium permanganate. The new compounds were characterized by UV-vis, NMR, EPR, and MS analysis, and their magnetic behaviour was investigated.
Hammett spectral LFER of some antioxidant substituted benzylidene hydrazines
2017
About nine (E)-(2,5-dinitrophenyl)-2-(substituted benzylidene)hydrazines have been synthesized by hydroxy apatite catalyzed condensation of 2,4-dinitrophenyl hydrazine and substituted benzaldehydes under microwave irradiation conditions. The obtained yields of these hydrazines are more than 85%. The purities of synthesized hydrazines are examined by the analytical and spectroscopic data reported earlier. The infrared spectral C=N, NH frequencies (v, cm -1 ) and the NMR spectral chemical shifts of CH, NH protons and carbons are assigned and are correlated with Hammett substituent constants, F and R parameter using single and multi-regression analysis. From the results of statistical analysis the effects of substituent on the group frequencies have been discussed. The antioxidant activities of these synthesized hydrazines were measured using DPPH radical scavenging method. The hydroxyand methoxysubstituted hydrazines shows significant antioxidant activity.
Rafidain Journal of Science
The 2-[(6-chloro-2-pyridyl) amino]benzoic acid (I) was synthesized viaUllmann-Goldberg coupling by reaction of anthranilic acid with2,6-dichloropyridine. The compound (I) was cyclized by using poly phosphoric acid (PPA) to give 9-chloro-11H-pyrido[2,1-b]quinazolin-11-one (II). The compound (II) reacted with hydrazine hydrate to give N-{11H-pyrido[2,1-b]quinazolin-11-one-9-yl} hydrazine (III). The compound (III) reacted with various aromatic aldehydes to yield the hydrazones (IVa-p). The reaction progress was followed by thin layer of chromatography (TLC). The physical constants and R f values were recorded. The synthesized compounds were confirmed via the spectral data (UV,I.R, 1 H-NMR, 13 C-NMR, mass spectra). The possible fragmentation pattrene of GC/MS for the compounds (IVa) were investigated (IVh).