Hyaluronic acid-based hydrogels: Drug diffusion investigated by HR-MAS NMR and release kinetics (original) (raw)
Hydrogels based on hyaluronic acid (HA) and agarose-carbomer (AC) units have been prepared and explored as drug delivery systems. The complex architecture of the polymer network, such as mesh size, HA molecular weight and drug-polymer non-covalent interactions across the 3D polymer matrix, strongly influence the release capability/profile of these materials. In this study, High-Resolution Magic Angle Spinning (HR-MAS) NMR Spectroscopy has been used to investigate the transport behaviour of two different drugs, such as ethosuximide (neutral molecule) 3 and sodium salicylate (net negative charge) within the AC and AC-HA hydrogel networks prepared with different mesh sizes. Analysis of the experimental data provides evidence of superdiffusive motion for all formulations containing sodium salicylate, while ethosuximide molecules undergo unrestricted diffusion within the gel matrix. We further speculate that the superdiffusive motion observed at the nanoscale can be responsible for the faster release of sodium salicylate from all hydrogel formulations.
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