Alternative lengthening of telomeres, ATRX loss and H3‐K27M mutations in histologically defined pilocytic astrocytoma with anaplasia (original) (raw)

Anaplastic pilocytic astrocytomas (PA) represent a challenging subset of tumors with unclear biological underpinnings. This study analyzed 57 resections from 36 patients to assess alternative lengthening of telomeres (ALT) and mutations in ATRX and H3-K27M. Results indicated a high prevalence of ALT (69%) and ATRX loss (57%) in anaplastic cases, with significant correlations to histological features and clinical outcomes. The findings suggest that anaplastic PA exhibit heterogeneous genetic characteristics that align with both PA and diffuse glioma profiles.