IL-12 Signals through the TCR To Support CD8 Innate Immune Responses (original) (raw)
Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production
Aldo Vacaflores
Molecular Immunology, 2017
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Peptide Antigen Priming of Naive, But Not Memory, CD8 T Cells Requires a Third Signal That Can Be Provided by IL-12
Clint Schmidt
The Journal of Immunology, 2002
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Reciprocal responsiveness to interleukin-12 and interferon-α specifies human CD8+ effector versus central memory T-cell fates
Ann Davis
Blood, 2009
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TCR‐pMHC encounter differentially regulates transcriptomes of tissue‐resident CD8 T cells
Derin Keskin
European Journal of Immunology, 2017
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T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-γ Signaling in T Cells
Guillaume VOGT
The Journal of Immunology, 2006
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T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN- Signaling in T Cells
Ariane Chapgier
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TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal
Charles-Antoine COUPET
The Journal of Immunology, 2009
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Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
Sophia Sarafova
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IL-12 is produced by antigen-presenting cells stimulated with soluble αβ TCR and restores impaired Th1 responses
Marian Szczepanik
International Immunology, 2000
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Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells
Guy Delespesse
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Signal 3 Cytokines as Modulators of Primary Immune Responses during Infections: The Interplay of Type I IFN and IL-12 in CD8 T Cell Responses
Ralph Tripp
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Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanisms
Shawn Hartman
Journal of immunology (Baltimore, Md. : 1950), 2014
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The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells
Bruno Laugel
Journal of Leukocyte Biology, 2011
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IL-15 is critical for the maintenance and innate functions of self-specific CD8 + T cells
Momoe Itsumi
European Journal of Immunology, 2009
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IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection
Sara Hamilton
Journal of Immunology, 2016
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Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells
Alexandra Corbett
European journal of immunology, 2016
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The TCR's sensitivity to self peptide–MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens
Sara Hamilton
Nature Immunology, 2014
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IL-12-Programmed Long-Term CD8+ T Cell Responses Require STAT4
C. Eppolito
The Journal of Immunology, 2006
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Innate signals compensate for the absence of PKC-θ during in vivo CD8+ T cell effector and memory responses
Martin Bachmann
Proceedings of the National Academy of Sciences, 2005
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A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T-cells
Zhabiz Solhjou
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CD8 Controls T Cell Cross-Reactivity
Bruno Laugel
The Journal of Immunology, 2010
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The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses
Matthew Martin
PLOS Pathogens, 2015
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IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals
Wolfgang Uckert
Journal of immunology (Baltimore, Md. : 1950), 2015
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Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism
Aldo Vacaflores
PLOS ONE, 2016
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Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation
Ádám Hagymási
The Journal of Immunology, 2008
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The Roles of IL-12 in Providing a Third Signal for Clonal Expansion of Naive CD8 T Cells
Clint Schmidt
The Journal of Immunology, 2002
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T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-{Gamma} Signaling In T Cells
Ariane Chapgier
The Journal of …, 2006
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TCR Signal Transduction in Antigen-Specific Memory CD8 T Cells
Miriana Moran
The Journal of Immunology, 2003
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CD8 T Cells in Innate Immune Responses: Using STAT4-Dependent but Antigen-Independent Pathways to Gamma Interferon during Viral Infection
Delia Demers
mBio, 2014
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Antigen-dependent and -independent contributions to primary memory CD8 T cell activation and protection following infection
Matthew Martin
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Shaping Successful and Unsuccessful CD8 T Cell Responses Following Infection
Allan Zajac, Maureen a. Cox
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and not Restricted to T and NK Cells of Secondary IFN{gamma} Secretion Receptor Expression Is Independent Autocrine Regulation of IL12
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CD8+ T Cells Sabotage Their Own Memory Potential through IFN- -Dependent Modification of the IL-12/IL-15 Receptor Axis on Dendritic Cells
Andrew Zloza, Tamson Moore, Jeremy O’Sullivan
The Journal of Immunology, 2012
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Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
Yufang Shi
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Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development
Ed Palmer
Science, 2009
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