Leiomiomatosis cutánea y uterina: Síndrome de Reed (original) (raw)
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Leiomiomatosis cutánea y uterina múltiple o síndrome de Reed
Piel, 2014
La leiomiomatosis cutá nea y uterina mú ltiple (MCUL), tambié n conocida como síndrome de Reed, leiomiomatosis cutis et uteri y leiomiomatosis mú ltiple, fue descrita en 1973 por Reed et al. Se caracteriza por la presencia de leiomiomas cutá neos de origen pilar en ambos sexos, leiomiomas uterinos en las mujeres y existe una variante asociada al carcinoma renal. Esta variante incluida dentro del mismo síndrome fue descrita en 2001 por Kiuru et al. 1 , y se conoce como leiomiomatosis hereditaria y carcinoma de cé lulas renales (HLRCC).
Uterine and Cutaneous leiomiomatosis Reed Syndrome
RESUMEN Los leiomiomas cutáneos son tumores benignos de músculo liso poco frecuentes, los cuáles pueden originarse en las diferentes localizaciones donde se encuentre este tipo de músculo. La asociación de leiomiomas cutáneos múltiples y leiomiomas uterinos se denomina síndrome de Reed, el cuál puede asociarse a carcinoma de células renales. Reportamos un caso de síndrome de Reed en una paciente mujer de 50 años. Palabras clave: Leiomiomatosis cutánea, Síndrome de Reed. SUMMARY Cutaneous leiomyomas are uncommon benign smooth muscle tumors that can be originated in any location where this type of muscle is found. The association of multiple cutaneous leiomyomas and uterine leiomiomas is called Reed´s syndrome. This syndrome can be associated as well with a renal cell carcinoma. We report a case of a 50 years old female patient with Reed´s syndrome.
Multiple Cutaneous and Uterine Leiomyomatosis or Reed Syndrome: A Retrospective Study of 13 Cases
Actas dermo-sifiliograficas, 2014
Multiple cutaneous and uterine leiomyomatosis (MCUL), or Reed syndrome, is characterized by the presence of cutaneous leiomyomas arising from the arrector pili muscles and, in women, by uterine leiomyomas. In some cases, MCUL is associated with renal cell carcinoma. This syndrome is an autosomal dominant disorder caused by a heterozygous germline mutation of the gene that encodes fumarate hydratase, a Krebs cycle enzyme that acts as a tumor suppressor. To review the cases of MCUL diagnosed at 2 university hospitals over a 5-year period (2008-2013). This was a retrospective study of 13 cases of MCUL that investigated demographic, clinical, and histologic characteristics, as well as possible associations with other diseases and treatments received. We identified 13 patients (10 women and 3 men) who had been diagnosed with MCUL. The mean age at diagnosis was 53 years. All the patients had multiple cutaneous leiomyomas; in 12 (92%) the distribution was clustered and 9 (69%) also had dis...
Leiomiomatosis cutánea múltiple
Piel, 2010
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Leiomiomatosis uterina, un viejo problema con nuevas soluciones
2002
Uterine leiomyomata is an old medical problem, with a high incidence in gynecology, it has been reported a frequency of 25% among women in reproductive age an almost 50% between pathology trials. Nowadays we have new therapeutic options. This disease is one of the most frequent causes of gynecology consultations, it is characterized by histology identification of tumors composed by smooth muscle and connective tissue. The objective of this bibliography revision about uterine myomas, is to show to no-gynecologists endoscopics an actual panorams of this clinic entity as well as different therapeutic options. The importance for general surgeons is mainly based, in the high frequency of uterine leiomyomata, also on its incidental identification in no-gynecologic surgery and finally in the fact that any surgical treatment above myomas has a direct negative impact on patient’s reproductive prognosis. Also it has been reported that 40% of women with uterine leiomyomata has an infertility h...
Progresos de Obstetricia y Ginecología, 2007
CASOS CLÍNICOS RESUMEN Los criterios valorados para el diagnóstico de malignidad en los tumores de músculo liso primarios vulvares son: tamaño ≥ 5 cm, márgenes infiltrantes, 5 o más mitosis por cada 10 campos de gran aumento, y atipia citológica moderada o grave. Con 3 o más de estos criterios, el diagnóstico será de leiomiosarcoma, y con uno o menos, de leiomioma. Cuando el tumor reúne sólo 2 criterios, el diagnóstico es de leiomioma atípico o leiomiosarcoma de bajo grado, y presenta un riesgo de recidiva local más que de enfermedad metastásica. Presentamos un caso de leiomioma atípico vulvar en una paciente de 87 años de edad, de 6,5 cm de eje máximo y de 5-7 mitosis por cada 10 campos de gran aumento, a la que se realizó un tratamiento conservador y un seguimiento de la evolución. PALABRAS CLAVE Leiomioma vulvar atípico. Leiomioma vulvar de bajo grado. Criterios diagnósticos.