P3-109 Religiosity predicts dementia in Israeli men (original) (raw)
2004, Neurobiology of Aging
were retained if significant. Results: In the final modal, MCI (OR = 28.9, p < 0.001), LLD (OR = 5.2, p = 0.010), APOE (OR = 3.1, p = 0.002), and age (OR = 1.1, p = 0.004 for each additional year) were significant main effects, with a trend for MCI by LLD interaction (p = 0.084). CVD (p = 0.357), education (p = 0.365), and gender (p = 0.407) were not significant. LLD by APOE interaction was significant (p = 0.045) with effect of LLD greater among NC (OR = 5.2) than among MCI (OR = 1.52). Analyses were repeated using only the sub-sample with CA at follow-up with comparable results. Conclusions: These results suggest that risk for development of dementia may be an interaction of presence of MCI, LLD, and the APOE gene, suggesting the incremental effect of LLD is greatest among those with no e4 allele.
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