Correlation between erythrocyte sedimentation rate (ESR) dynamics and blood luminescence studied using of opto-electronic devices (original) (raw)
Related papers
2009
To analyze erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) tests in 2 databases of consecutive patients with rheumatoid arthritis (RA) over 25 years between 1980 and 2004, in Finland and the USA. Methods. Databases of 1892 patients of 7 rheumatologists in Jyväskylä, Finland, and 478 of one author in Nashville, TN, USA, seen in usual care, were reviewed for the first recorded ESR and CRP, and all RF tests. Results. Median ESR at presentation was 30 mm/h at both sites. Mean ESR was 36 mm/h in Jyväskylä and 35 mm/h in Nashville. ESR was < 28 mm/h in 45% and 47% of patients at the 2 sites, respectively. CRP was normal in 44% and 58%, and all RF tests were negative in 38% and 37%, respectively. Both ESR and CRP were normal in 33% and 42% of patients, and all 3 tests were normal in 15% and 14% of patients in whom they were assessed. All 3 tests were abnormal in only 28% in Jyväskylä and 23% in Nashville. Conclusion. A majority of patients with RA seen between 1980 and 2004 had abnormal ESR, CRP, or RF. However, more than 37% of patients had ESR < 28 mm/h, normal CRP, or all negative RF tests. Similarities of laboratory test data at 2 sites on different continents with different duration of disease suggest generalizability of the findings. Normal ESR, CRP, and RF are seen in a substantial proportion of patients with RA at this time.
Turkish Journal of Medical Sciences
Background/aim: The objectives were to define the distribution of rheumatic diseases in patients with erythrocyte sedimentation rate (ESR) ≥ 100 mm/h and to find variables that can differentiate main study groups from others. Materials and methods: Charts of patients admitted with ESR ≥ 100 mm/h between 2015 and 2020 were reviewed. Patients were divided into four diagnostic groups based on etiology: infection (without a rheumatic diagnosis), oncologic (without a rheumatic diagnosis), rheumatic, and no definitive diagnosis. Patients with the rheumatic diagnosis were divided into three main study groups: those who had been recently diagnosed with a rheumatic disease, those who had a flare-up of the rheumatic disease, and those who had an infection in the course of the rheumatic disease. Appropriate statistical tests and decision-tree analysis by R and ROC curve were applied. p < 0.05 was considered statistically significant.Results: A total of 2442 patients (311 (12.7%) with rheumatic disorders) were identified. Eightysix (27.7%) patients had newly diagnosed rheumatic disease (41; 47.7% with vasculitis); 111 (35.7%) had rheumatic disease flare-up (92; 82.9% with inflammatory arthritis); and 114 (36.6%) had coexisting infection (61; 53.5% inflammatory arthritis). Irrespective of the study group, the most commonly encountered diseases were rheumatoid arthritis and spondyloarthritis. Serum albumin levels (2.78 mg/dL) and platelet count (290/mm 6) were valuable to discriminate disease flare-up and coexisting infection; moreover, high ferritin levels were accounted for adult-onset Still disease among patients with newly diagnosed rheumatic diseases. Conclusion: Extremely high ESR is still a valuable clinical parameter, and rheumatic causes are significant besides malignancy and infections. Albumin, thrombocyte count, and ferritin are other tests that clinicians should consider when caring for a patient with ESR ≥ 100 mm/h who has rheumatic disease.
Concordant Message of Different Inflammatory Markers in Patients with Rheumatoid Arthritis
The acute phase reaction is an unspecific response to inflammatory stimuli characterized by alterations in the concentration of several plasma proteins. It is of great clinical value to monitor the inflammatory state in patients with rheumatoid arthritis. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are the assays most widely used to measure the acute phase response, but there are also several other inflammatory markers (e.g. fibrinogen, haptoglobin, a,-acid glycoprotein, a,-antitrypsin, interleukins (IL), serum amyloid component A (SAA)). We have studied the interrelationships between several of these markers (ESR, Haptoglobin, Fibrinogen, CRP, SAA and IL-6) in rheumatoid arthritis patients. There was a good correlation between all acute phase markers in serum (p<.Ol). We found especially strong correlations between S-CRP and SAA (p<.OOOOOl) and between ESR and P-fibrinogen (p=.000004). The strong correlation indicates that P-fibrinogen could be used instead of ESR in monitoring rheumatoid arthritis patients. This would increase the specificity of the examination as ESR may be influenced by several factors other than the inflammatory response. There were no significant correlations between acute phase markers in serum or plasma and clinical index.
2015
Background: Laboratory tests such as the erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) have been used as markers of inflammation and disease activity in rheumatoid arthritis (RA), although there is still no clear consensus on when to use one, the other, or both. Objective: To determine ESR and CRP values in active RA patients and their correlation with different parameters of disease activity. Patients and Methods: Eighty patients with active RA, attending rheumatology department at Benha Teaching Hospital, diagnosed according American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) revised criteria were included. The patients' tender and swollen joint counts were calculated. Laboratory investigations were done including ESR by Westergren method and CRP by ELISA method, assessment of disease activity using DAS28 score. Results: All patients showed disease activity at time of the study, their DAS28 score was ranged from 2.9 to 7.5 (...
Caspian journal of internal medicine, 2013
BACKGROUND Erythrocyte sedimentation rate (ESR) is one of the predictors of improvement in handling rheumatoid arthritis. This study was designed to define and compare the time of achieving normal ESR and also the percentage for the normalization of this marker at several points of time in two different combination therapies. METHODS Fifty-two rheumatoid arthritis patients randomly received methotrexate, chloroquine, prednisolone (MCP) or azathioprine, chloroquine, prednisolone (ACP) and all were followed up for 34 weeks. Chloroquine and azathioprine were given, 150 mg/d and 2 mg/kg/d, respectively. Methotrexate was given, 0.2 mg/kg/week and simultaneously increased 2.5 mg monthly if no clinical response was seen. Prednisolone was started, 0.3 mg/kg/d and tapered after one week. ESR at baseline and during follow-up were checked. The data were collected and analyzed. This clinical trial was registered in the Iranian Registry of Clinical Trials (www.irct.ir) with registration number I...
Haematological Markers of Disease Activity in Rheumatoid Arthritis
2018
The relation between hematological markers among patients with active disease of Rheumatoid Arthritis (RA) shown a significant change in hematological parameter but cannot be used as specific and sensitive method to diagnosis of RA diseases. Whereas many hematological parameters are effecting by systemic inflammation. Aim: To investigate possible relationships between the hematological markers and disease activity of RA. Materials and methods: A total of 50 samples were collected from RA patients at NIMS and SDM Hospital, Jaipur-India. Whereas samples subjected to laboratory investigations, RF by Dry chemistry method, CBC by hematological analyzer/ five parts, Hb by SLS method and ESR by Automated Analyzer. Results: A total of 50 samples in RA patients as 42 were female and n= 8 were male). 27 patients with high disease activity (RF>100 IU/ml) group A and 23 patients with mild to moderate disease activity ( <100 IU/ml) group B. The incidence of disease regarding to the gender ...
A rapid method for testing the erythrocyte sedimentation rate
Journal of Diagnostic Pathology
The erythrocyte sedimentation rate (ESR) is one of the most common and traditional laboratory tests in the world for detecting acute and chronic inflammation. This simple test has served as a nonspecific indicator of presence of disease. It also has been found useful in monitoring response to therapy, especially in rheumatologic disease. It reflects both plasma concentration of acute-phase proteins of large molecular size and anaemia. The ESR test is easy to perform and inexpensive, is used today as a routine test worldwide. However, the ESR has some demerits, in requiring large volume of sodium citrate or EDTA blood and at least 1 hr testing time. The minimum of 1 hr testing time is not practical for modernized laboratories. In this paper we investigated the possibility of using a rapid ESR test done on an inclined tube. We compared the results obtained by the rapid method and the traditional Westergren method of ESR using Pearson correlation. Blood samples from 153 patients with ESRs ranging from 1-165 were used for the study. Four ml of sodium citrate blood (3.2 ml of blood & 0.8ml of 3.8% of sodium citrate) is prepared and two Westergren tubes filled. Both tubes are mounted on two separate Westergren tube racks. After mounting, one ESR tube is tilted to an angle of 45 degrees from vertical and readings were taken at 4,
Pakistan Journal of Medical and Health Sciences, 2021
Objective: To determine the relationship between serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) with active disease in patients with juvenile rheumatoid arthritis (JRA). Methods: This is a cross-sectional analytical study conducted at the Department of Paediatrics, Abbasi Shaheed Hospital, Karachi for one-year duration from April 2020 to April 2021. All patients who met the MJA’s American College of Rheumatology (ACR) criteria were enrolled in the study. The ACR 20 improvement criteria were used to define the pardon of the disease, and those who met the ACR20 recovery criteria were included in the remission group. Laboratory tests such as PCR and ESR. Statistical analysis was performed using SAS software (version 10.3). Results: The study involved 90 patients, including 28 in the remission group (31.2%) and 62(68.88%) in the active disease group. There were 61.11% (n = 55) of females, and the ratio of males to females was 3: 4. The mean age of the subjects w...