Parkinsonism and basal ganglia volumes in first-episode psychosis (original) (raw)

European Psychiatry, 2016

Abstract

IntroductionParkinsonian motor signs are the most frequent of the genuine motor abnormalities present in drug-naïve patients with schizophrenia, and are also present in patients with a first-episode of psychosis (FEP).ObjectiveTo study whether there are differences in basal ganglia volumes depending on the presence of Parkinsonism in FEP.MethodsForty-six patients with a FEP were included in the study. Twenty-three controls were included to normalise patients’ brain volume data. Parkinsonism was assessed with the UKU scale. Brain volumes were obtained with MRI (1.5 Tesla Siemens Avanto). Reconstruction and volumetric segmentation was made with the Freesurfer© software (http://surfer.nmr.mgh.harvard.edu/). Patients were divided into two groups, considering the presence/absence of Parkinsonism (UKU total score cutoff point = 4). Patients have been treated with antipsychotics a mean of less than 2 months. There were not significant differences in the total exposure to antipsychotics bet...

Pablo Lecumberri hasn't uploaded this paper.

Let Pablo know you want this paper to be uploaded.

Ask for this paper to be uploaded.