Current Research on Therapy in Alzheimer’s Disease Experimental Model: Beta-Amyloid1-42 Induction (original) (raw)

Alzheimer’s disease (AD) is a neurodegenerative disorder commonly associated with brain ?-amyloid accumulation (A?). Early in disease, individuals have impairment in short-term memory, but keeps alert preserved sensory and motor functions, progressing to cognitive functions total loss. The aim of this study is to present main substances currently investigated in Alzheimer’s disease experimental model induced by A?1-42 and its possible therapeutic actions. For this, we realized an exhaustive literature research, and main results data compiled and analyzed. Thus, there were observed three agents’ classes used to treat AD: antioxidants, anti-inflammatory, and calcium homeostasis regulators, with 15 substances found. In conclusion, it can be seen that these agents have beneficial results which suggest actions that may be used in clinical practice to pathology treatment.