Case characteristics, clinical data, and outcomes of hospitalized COVID-19 patients in Qom province, Iran: a prospective cohort study (original) (raw)
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BioMed Research International
Background. The outbreak of coronavirus disease 2019 (COVID-19) dates back to December 2019 in China. Iran has been among the most prone countries to the virus. The aim of this study was to report demographics, clinical data, and their association with death and CFR. Methods. This observational cohort study was performed from 20th March 2020 to 18th March 2021 in three tertiary educational hospitals in Tehran, Iran. All patients were admitted based on the WHO, CDC, and Iran’s National Guidelines. Their information was recorded in their medical files. Multivariable analysis was performed to assess demographics, clinical profile, outcomes of disease, and finding the predictors of death due to COVID-19. Results. Of all 5318 participants, the median age was 60.0 years, and 57.2% of patients were male. The most significant comorbidities were hypertension and diabetes mellitus. Cough, dyspnea, and fever were the most dominant symptoms. Results showed that ICU admission, elderly age, decre...
Archives of Iranian Medicine
Background: We studied the clinical characteristics and outcomes of 905 hospitalized coronavirus disease 2019 (COVID-19) patients admitted to Imam Khomeini Hospital Complex (IKHC), Tehran, Iran. Methods: COVID-19 patients were recruited based on clinical symptoms and patterns of computed tomography (CT) imaging between February 20 and March 19. All patients were tested for the presence of COVID-19 RNA. The Poisson regression model estimated the incidence rate ratio (IRR) for different parameters. Results: The average age (± standard deviation) was 56.9 (±15.7) years and 61.77% were male. The most common symptoms were fever (93.59%), dry cough (79.78%), and dyspnea (75.69%). Only 43.76% of patients were positive for the RT-PCR COVID-19 test. Prevalence of lymphopenia was 42.9% and more than 90% had elevated lactate dehydrogenase (LDH) or C-reactive protein (CRP). About 11% were severe cases, and 13.7% died in the hospital. The median length of stay (LOS) was 3 days. We found higher r...
2020
Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia and risk factors associated for mortality. Methods: In this retrospective cohort study, we included inpatient with acute respiratory distress syndrome at Golestan University of Medical Sciences Hospitals (Golestan province, Iran) who had been discharged or had died in 2020. Epidemiological, clinical, and laboratory data, including samples for viral RNA detection, were extracted from electronic medical records and compared between recovered and died cases. We used multiple logistic regression methods to explore the risk factors associated with in-hospital death.Results: In overall 2,835 acute respiratory distress syndrome patients were included in this study, of these patients, 874 (30.83.9%) were positive for 2019nCoV, and 1...
2020
Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widespread. Objectives: We aim to investigate the demographic and clinical characteristics associated with COVID-19 infection between January 24 to June 10, 2020. Methods: All data related to tested patients (positive and negative cases) were extracted from the integrated health information system (IHIS) between January 24 to June 10, 2020. Statistical analyses were performed using data related to the anamnesis of all patients, odds ratios (OR) of COVID-19 infection in defined subgroups including contact history, partial pressure of oxygen (PO2) higher than 93 mmHg, the muscle-pain symptom, the cough symptom, and the fever symptom. Results: The COVID-19 infection was significantly associated with contact history (OR 5.25, [95% CI 4.35 to 6.34], P-value < 0.0001); PO2 higher than 93 mmHg (OR 1.74 [95% CI 1.44 to 2.22], P-value < 0.0001); musc...
Original Article, 2021
Introduction: Following the widespread pandemic of the novel coronavirus diseases (COVID-19), this study has reported demographic and laboratory findings and clinical outcomes of patients with COVID-19 admitted to a tertiary educational hospital in 99 days in Iran. Objective: We aimed to investigate in-hospital death risk factors including underlying diseases and describe the signs, symptoms, and demographic features of COVID-19 patients. Methods: All confirmed COVID-19 cases admitted from 22 February to 30 May 2020 were extracted from hospital records. A follow-up telephone survey was conducted 30 days after discharge to acquire additional data such as survival status. Distribution of demographic and clinical characteristics was presented based on survival status during hospitalization. All analyses were performed using STATA version 14 with a level of significance below 5%. Results: Among 1083 recorded patients, the rate of survival and death was 89.2% (n=966) and 10.8% (n=117), respectively. 62% of the cases (n=671) were male. The mean recovery time was 1.90 (3.4) days in survived cases, which was significantly lower than that in deceased cases 4.5 (5.2) days, p<0.001). A significantly higher rate of death was observed among patients above the age of 60 years (24.8%, p<0.001), cases with hypertension (25.4%, P<0.001) and cases without cough (17 %, p=0.002) but with shortness of breath (16.5%, p=0.001). Conclusions: Our study emphasized the significant effect of different underlying conditions as mortality factors among COVID-19 patients, namely older age spectrum, hypertension, and ischemic heart disease. By acknowledging the epidemiologic pattern and mortality factors, we have more tools to prioritize and make better judgments, and more lives can be saved.
Iranian Red Crescent Medical Journal, 2021
Background: Coronavirus disease 2019 (COVID-19) was introduced by the World Health Organization as a pandemic and emergency for human health. This study aimed to investigate the clinical characteristics of patients infected with COVID-19 in Guilan Province, Iran. Methods: This retrospective study was conducted on 1,000 patients with a definitive diagnosis of COVID-19 pneumonia admitted to six hospitals in Guilan Province, Iran, from April 13 to June 14, 2020. This study evaluated the patients' clinical information, demographic characteristics, laboratory results, and chest computed tomography scans. Findings: The mean age of the patients was obtained at 55±1.3 years, and the majority (n=800; 80%) of the cases were male. Furthermore, most patients had underlying diseases, including respiratory system disease (n=173; 17.3%), cardiovascular disease (n=711; 71.1%), and malignancy (n=146; 14.6%). The most common causes of the infection with COVID-19 included the presence in crowded...
Journal of Parathyroid Disease, 2023
Introduction: Since December 2019, coronavirus disease 2019 (COVID-19) has rapidly expanded to cause a worldwide pandemic. Objectives: We aimed to report the clinical characteristics of infected patients at the first wave in northwest of Iran. Patients and Methods: In this study, the epidemiological, demographic, clinical, and laboratory data of 1152 confirmed patients with COVID-19 who were admitted to two main hospitals at the first outbreak in northwest of Iran were collected and analyzed. Results: The most common clinical manifestations at onset were cough (65.8%), dyspnea (40.2%), myalgia (37.8%), and fever (63.4%), loss of appetite (47%), chest pain (38.6%), and headache (49.4%). While the less common were agitation (17.3%), vomiting (22.2%), diarrhea (16.7%), and nausea (24.3%). Laboratory data indicated significant correlation between lymphocyte counts with the severity of the disease based on O 2 saturation. Conclusion: Overall, assessment the clinical data of COVID-19 patients play a crucial role in understanding the outbreak of novel viral pneumonia, which helps to identify high risk individuals with COVID-19.
Modern Care Journal
Background: Coronavirus, coronavirus disease 2019 (COVID-19), in humans, mainly causes respiratory and gastrointestinal manifestations that can range from a simple cold to severe clinical symptoms or death. On the other hand, COVID-19 patients’ hospitalization in the intensive care unit (ICU) have serious problems, which can affect their mortality; therefore, the awareness of these problems has a main role in decision-making in the early stages. Objectives: This study aimed to evaluate the clinical features and outcomes of patients with COVID-19 admitted to the ICU. Methods: This cross-sectional (descriptive-analytical) study was conducted on patients with COVID-19 pneumonia admitted to the ICU of Valiasr Hospital, Birjand, Iran, in 2020. A total of 111 patients, including 51 female and 63 male subjects, were enrolled in this study using convenience sampling. Demographic data, comorbidities, signs and symptoms, radiological findings, supportive methods of oxygen therapy, and clinica...
Journal of Preventive Medicine and Hygiene, 2021
Summary Background We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia and risk factors associated for mortality. Methods In this study, we included inpatient with acute respiratory distress syndrome at Golestan Hospitals who had been discharged or had died in 2020. Epidemiological, and clinical data were extracted from electronic medical records and compared between recovered and died cases. We used multiple logistic regression methods to explore the risk factors associated with in-hospital death. Results Overall 2,835 acute respiratory distress syndrome patients were included in this study, and 874 (30.83%) were positive for 2019-nCoV. Five hundred and sixty-three patients (19.86%) died, 1,687 patients (59.51%) were recovered. Of the total deaths, only 288 (10.15%) were attributed to COVID-19. The most common symptoms at onset of illness were respiratory distress [1,795 (63.32%)], fever [1,601 (56.47%)], dry cough [1,595 (56.26%)], s...
Journal of research in clinical medicine, 2022
Introduction Coronavirus disease 2019 (COVID-19) is an acute respiratory syndrome that has outspread to most countries in a few months. The burden of COVID-19 has been on the increase globally. 1 Since December 2019, more than 137 million people have been infected, with approximately 3 million deaths. 2 Patients with COVID-19 mainly have a fever, myalgia or fatigue, and dry cough. Although most patients are believed to have a favorable prognosis, elderly patients and those with chronic diseases are at risk for more severe illness and mortality. Patients who have the severe disease might develop shortness of breath and hypoxemia within one week of the onset of the disease, which can rapidly progress to acute respiratory distress syndrome (ARDS) or organ failure. 3 Initial analysis of patients hospitalized in China with COVID-19 have shown that diabetes, hypertension, and cardiovascular diseases are very common among them, and patients with these comorbidities are more exposed to have poor clinical outcomes. 4 In a recent study of 201 patients with COVID-19 pneumonia, risk factors associated with ARDS development and progression from ARDS to death included age, neutrophilia, organ dysfunction, and coagulation disorders. 3 The time of clearance of coronavirus RNA depended on sex, disease severity, and lymphocyte function. 5 The clinical spectrum of COVID-19 infection is wide, including asymptomatic infection, mild upper respiratory tract disease, and severe viral pneumonia associated