Photoactivable peptides for identifying enzymesubstrate and proteinprotein interactions (original) (raw)
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Christopher Schofield
2009
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Targeting Protein-Protein Interactions in the HIF System
Christopher Schofield
ChemMedChem, 2016
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Analysis of HIF-prolyl hydroxylases binding to substrates
Luis Peso
Biochemical and Biophysical Research Communications, 2006
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Kinetic Rationale for Selectivity Toward N-and C-Terminal Oxygen-Dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
Christopher Schofield
Journal of Biological Chemistry, 2008
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Christopher Schofield
Nature communications, 2016
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Determination and comparison of specific activity of the HIF-prolyl hydroxylases
Yuguang Zhao
FEBS Letters, 2004
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Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
Eoin Cummins
Cells, 2019
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Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
Roman Fischer
Journal of Biological Chemistry, 2011
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Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
Luis Del Peso
Biochemical Journal, 2007
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Constitutive/Hypoxic Degradation of HIF-α Proteins by the Proteasome Is Independent of von Hippel Lindau Protein Ubiquitylation and the Transactivation Activity of the Protein
Jaime Caro
Journal of Biological Chemistry, 2007
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Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology
Jose Morachis
Analytical Biochemistry, 2009
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Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
Christopher Schofield
Journal of Biological Chemistry, 2011
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Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases
Pekka Heikkinen
Biochemical …, 2004
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Faculty of 1000 evaluation for Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
Michael Maroney
F1000 - Post-publication peer review of the biomedical literature, 2006
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Does inhibition of degradation of hypoxia-inducible factor (HIF) α always lead to activation of HIF? lessons learnt from the effect of proteasomal inhibition on HIF activity
Eric Stanbridge
Journal of Cellular Biochemistry, 2008
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2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
Christopher Schofield
Chemical communications (Cambridge, England), 2018
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Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-inducible Factor-1alpha by the von Hippel-Lindau Tumor Suppressor Gene Product
Teresa Pereira, Keiji Tanimoto
Journal of Biological Chemistry, 2003
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Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions
Jaime Caro
Journal of Biological Chemistry, 1997
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An Endoplasmic Reticulum Transmembrane Prolyl 4-Hydroxylase Is Induced by Hypoxia and Acts on Hypoxia-inducible Factor
J. Myllyharju
Journal of Biological Chemistry, 2007
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Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
Carsten Willam
The EMBO Journal, 2001
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Identification of an Alternative Mechanism of Degradation of the Hypoxia-inducible Factor-1
Teresa Pereira
Journal of Biological Chemistry, 2008
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The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen
Luis Peso
Journal of Biological Chemistry, 2003
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Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain
Christopher Schofield
ChemBioChem
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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
Emily Flashman
Proceedings of the National Academy of Sciences, 2006
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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
Mircea Ivan
Proceedings of the National Academy of Sciences, 2002
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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
william kim
Science, 2001
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Intracellular localisation of human HIF-1alpha hydroxylases: implications for oxygen sensing
Joachim Fandrey
Journal of Cell Science - J CELL SCI, 2003
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
Sonia Rocha
Nature Communications, 2016
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Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases
Irina Gaisina
Biochemistry (Moscow), 2012
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Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide
Joachim Fandrey
Journal of Biological Chemistry, 2008
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Cloning and characterization of the rat HIF-1α prolyl-4-hydroxylase-1 gene
David Light
Protein Expression and Purification, 2005
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The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
Philippe Hasgall
Molecular and cellular biology, 2007
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Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing
Wolfgang Jelkmann
Journal of Cell Science, 2003
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Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding
Federico Falchi
PloS one, 2014
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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen
Christopher Schofield
FEBS Journal, 2010
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