17β-estradiol residue determined in minced meat and it’s Carcinogencity in mice (original) (raw)
2013
Abstract
T main objective of this research to study carcinogenic effects of 17β-estradiol in mice by studying on haematological parameters (Hb, PCV, RBC, WBC and DWBC), mitotic index and histopathological changes of ovary, uterus and mammary gland. The following results which obtained from the current research: The effects of 17β-estradiol for six months on blood picture had no-significant differences on the blood haemoglobin (Hb) (11.55 and 11.69 gm/dl), total number of red blood cells (RBC) counts in the peripheral blood. RBC counts were 7.48 and 6.98 × 106/mm3 for the two groups respectively. Basophiles percent (3.40 and 3.54%) also (8.68 and 8.09%) for Monocytes percent for the two experimental groups respectively. Significant decrease (P˂0.05) in PCV% were noticed between the control and treated group (37.40and 31.28 %) respectively, and Lymphocyte percent (49.00 and 46.03%). Also significant increases (P˂0.05) were observed in the WBC count between the control and the second group (7.0...
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