A Bone Metastasis Nude Mouse Model Created by Ultrasound Guided Intracardiac Injection of Breast Cancer Cells: the Micro-CT, MRI and Bioluminescence Imaging Analysis (original) (raw)
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Endoprosthetic Reconstruction in the Limb Salvage Surgery for Treatment of Malignant Bone Tumors
Journal of the Korean Orthopaedic Association, 2015
Figure 1. Osteosarcoma of the distal femur. (A) Osteolytic lesion of the medullary canal and periosteal reaction are seen on the plain radiograph. (B) Intramedullary geographic lesion of low signal is seen on the T1 weighted magnetic resonance imaging. (C) The image shows endoprosthetic replacement with uncemented fixation of the distal femur.
Evaluation of the Performance of Lumipulse G1200 for Tumor Marker Assays
Laboratory Medicine Online, 2012
G1200 (Fujirebio, Tokyo, Japan)이 국내에 도입되었다. 저자들은 종양표지자인 carcinoembryonic antigen (CEA), α-fetoprotein (AFP), cancer antigen 125 (CA125), cancer antigen 15-3 (CA15-3), cancer antigen 19-9 (CA19-9), prostate specific antigen (PSA), protein induced by vitamin K absence or antagonist-II (PIVKA-II),
Adenoid cystic carcinoma of the breast: case report and review of literature
The Annals of The Royal College of Surgeons of England, 2012
We report the case of a patient who presented with a painful breast lump that turned out to be an adenoid cystic carcinoma of the breast. The literature is reviewed, highlighting the good prognosis associated with this rare condition and the current preferred treatment modalities.
Journal of the Korean Glaucoma Society
Purpose: We describe a novel use of intracameral Indocyanine green (ICG) to confirm aqueous outflow to collector channels and aqueous veins after trabecular microbypass Schlemm's canal stent insertion (iStent inject ® W; Glaukos Corporation, Laguna Hills, CA, USA). Case summary: We report three cases of glaucoma patients who underwent trabecular microbypass stent to observe aqueous outflow into episcleral veins using intracameral ICG dye injection. 0.5% ICG dye was injected intraoperatively into the anterior chamber near the stents. Automated irrigation or manual injection of balanced salt solution was used to pressurize the eye after ICG injection. We confirmed the episcleral and intrascleral vein engorgement and aqueous egression with ICG in two of the three cases. Although one case did not demonstrate the ICG egression into episcleral vein, episcleral vein engorgement was observed immediately. Conclusions: To the best of our knowledge, this is first report using ICG dye to identify the aqueous outflow, especially trabeculocanalicular outflow during trabecular microbyapss stenting. Intracameral ICG dye injection might be safe and effective to identify aqueous outflow and Schlemm's canal stent patency during trabecular microbypass stents implantation.
Journal of Laboratory Medicine and Quality Assurance
Background: Commutability is essential to harmonize different measuring systems and to evaluate the performance of participating laboratories in external quality assessment (EQA). This study aims to assess the commutability of EQA materials in the tumor marker program of the Korean Association of External Quality Assessment Service. Methods: We analyzed commercial quality control (QC) materials, individual patient samples, and frozen human serum pools (FSPs) based on the Clinical and Laboratory Standards Institute guidelines. Alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and total prostate-specific antigen (PSA) were assayed in triplicate in all samples using four analytical systems at the three laboratories. The results obtained from pairs of assays were plotted and assessed using Deming regression analysis. The criterion for commutability was a 95% prediction interval, and bias for noncommutability was calculated. Results: FSPs were commutable in all AFP, CEA, and total PSA assay methods. Bias for AFP, CEA, and total PSA ranged from-203% to 27%,-67% to 45%, and-9% to 12%, respectively. Commercial QC materials for AFP and PSA were commutable in four assays, whereas for CEA, noncommutability was observed. Conclusions: Our results validated that the frozen serum pools were commutable across different platforms for tumor marker assays. Therefore, validation findings from materials like FSPs and information about their commutability needs to be reported, for the applicability of EQA programs.
Autophagy of Human Tenon's Capsule Fibroblasts Induced by Mitomycin-C
Journal of the Korean Ophthalmological Society, 2011
The present study investigated whether an autophagic process is involved in the apoptotic death of human tenon's capsule fibroblasts (HTCFs) caused by mitomycin-C. Methods: An autophagic phenotype was tested using fluorescence microscopy and flow cytometry with specific biological staining dyes including monodansylcadaverine and acridine orange and microtubule-associated protein 1 light chain 3 (LC3). Results: Treatment with mitomycin-C (0.4 mg/ml) increased the acidic vesicular organelles of tenon's capsule fibroblasts in a time dependent manner. Mitomycin-C induced both LC3-II cleavage and beclin-1 expression. 3-MA, a pharmacological inhibitor of autophagy, inhibited the mitomycin-C induced increase of acidic vesicular organelleS. Conclusions: Autophagy was induced with 0.4 mg/ml mitomycin-C in tenon's capsule fibroblasts. And, autophagic mechanisms may be involved in the early stage of apoptosis of fibroblasts.
Docetaxel as Second-line Monotherapy for Advanced Non-small Cell Lung Cancer
Tuberculosis and Respiratory Diseases, 2005
Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second-line chemotherapy, for which Docetaxel (Taxotere ®) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinumbased chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first-line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/m 2 or 100 mg/m 2 , with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression-free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. ≥ 60 years: 6.6 months, p = 0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment-related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-smallcell lung cancer who failed first-line platinum-based chemotherapy.
Carotid Cavernous Fistula: Role of Open Surgery in The Era of Endovascular Treatment
Nepal Journal of Neuroscience, 2017
A 18-year-old right handed girl presented with progressive proptosis, chemosis, diplopia and an orbital bruit of right eye, 3 days after alleged history of fall from a tree, The intraocular pressure was increased. The suspected diagnosis of a direct carotid cavernous fistula (CCF) was confirmed by CT angiography CT Angiography showed direct fistulous communication of cavernous segment of right internal carotid artery with right cavernous sinus (type A right CCF) and linear minimally displaced fracture of right zygomatic arch and linear undisplaced fracture of wall of right orbit. The patient underwent right pterional craniotomy and transcavernous occlusion of fistula of right internal carotid artery (ICA). Surgery was performed with gradual resolution of the symptoms and normalization of the intraocular pressure.The pathogencsis, symptomatology, treatment of carotid cavernous fistulas are discussed.Nepal Journal of Neuroscience, Volume 14, Number 1, 2017, Page: 36-39