Frontal cortex and normal aging: A voxel-based morphometry MRI study of healthy individuals (original) (raw)

Alzheimer's & Dementia, 2013

Abstract

for significance using a bootstrapping method (Preacher & Kelley, 2010) with 10000 iterations. Results: Both HC (P<0.005) and ERC (P<0.0001) were significantly related to DMN connectivity while controlling for age and total grey matter. HC (Figure 1A) and ERC (Figure 1B) show similar patters of relationship with the DMN at the map level. ERCmediates the relationship between HC and DMN connectivity as assessed by a bootstrapping method (mediation ratio1⁄40.42, indirect effect1⁄41.03*10 -4, confidence interval1⁄4[3.35*10 -5 to 1.83*10 -5], p<0.001). Amyloid burden did not modify this effect. Conclusions: First, we find that structural measures of the MTL affect DMN connectivity above and beyond the effects of nonspecific greymatter and age. Second,we find further evidence for a structural/functional pathway between hippocampus and the DMN that is mediated by entorhinal cortex. Longitudinal analyses will elucidate the order in which these regions are impacted during AD development.

Luciana Santos hasn't uploaded this paper.

Let Luciana know you want this paper to be uploaded.

Ask for this paper to be uploaded.