Increased oxidative damage in the plasma of adult type 2 diabetics with poor glycemic control (693.7) (original) (raw)

The FASEB Journal

Abstract

Increased oxidative damage in the plasma of adult Type 2 diabetics with poor glycemic control Increasing evidence associates oxidative stress with the pathogenesis of Type 2 Diabetes (T2DM). Nonetheless, the available data related to oxidative stress and its relationships with glycemic status among T2DM patients are scarce and contradictory. Our goal was to investigate the relationships of metabolic control of T2DM with oxidative damage and antioxidant status. T2DM Emirati adults (n=187), participating in the Skills for Change randomized intervention trial and recruited from seven different ambulatory health care centers in Al Ain, United Arab Emirates, were considered. 24 h-recall was collected. Anthropometry and HbA1c were assessed. Aantioxidant status markers were measured: Vitamin C, ABTS, Ferric Reducing Ability of Plasma (FRAP) and Glutathione (GSH). After stratification on HbA1c and age, oxidative damage (Malonaldehyde (MDA), protein carbonyls) were assessed in a sub-sample (n=47). Means ± s.d. or ...

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