Low Titers of Human Anti-Oxldl Autoantibodies Are Associated with Unstable Coronary Disease (original) (raw)

2008, Atherosclerosis Supplements

Background and aims: Metabolic syndrome is considered an inflammatory state associated to endothelial dysfunction. The main objective of the present study was to determine whether soluble and leukocitary cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Moreover, other circulating markers of different candidate atherogenic risk factors were also studied. Methods: Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male controls were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors: insulin, HOMA, QUICKI, lipoprotein profile, HDL composition, CETP, LpPLA2, VCAM-1, ICAM-1, E-Selectin (ELISA), and leukocitary CD18, CD49d and CD54 (flow cytometry). Results: Patients with metabolic syndrome showed a) hypoadiponectinemia (4551±2302 vs. 5865±2548 ng/ml, respectively; p<0.05), b) an atherogenic lipoprotein profile, c) altered HDL chemical composition, d) higher CETP activity, e) diminished Lp-PLA2 activity (6.5±1.9 vs. 7.3±2.2, p<0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and f) high soluble (VCAM-1: 17±5 vs. 13±4 ng/ml, respectively; p<0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52±15 vs. 45±12 arbitrary units, respectively; p<0.0005; and lymphocyte CD49d: 312±56 vs. 284±64 arbitrary units, respectively; p<0.05). Conclusions: The increment in soluble and leukocitary cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to atherosclerotic cardiovascular disease.