Correction: Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis (original) (raw)

The study integrates metabolomic data from a meta-analysis with transcriptomic profiles to highlight the significant elevation of sphingosine kinase 1 (SPHK1) levels in pancreatic ductal adenocarcinoma (PDAC), especially in patients with a history of pancreatitis. Utilizing metaboAnalyst, the research identifies distinct metabolic pathways, including increased glycerophospholipid and sphingomyelin pathways, and characterizes alterations in specific metabolites across multiple studies, thereby providing insights into potential biomarkers and therapeutic targets in PDAC.