Quantitative analysis of cellular networks: cell cycle entry (original) (raw)

This research examines the dynamics of the cell cycle entry process, focusing on the interactions between signaling pathways and regulatory proteins such as E2F and Rb. It proposes a mechanistic model that integrates existing phenomenological models to describe the stochastic behavior of cell cycle reentry, highlighting the impact of feedback mechanisms and external stimuli (like serum concentration) on transition rates and time delays in E2F activation. Experimental data from various serum concentrations and inhibitor treatments support the model, providing insights into how the activation threshold and bistable behavior contribute to cell cycle regulation.