The Transcriptional Landscape of the Mammalian Genome (original) (raw)

This study provides a comprehensive analysis of the transcriptional landscape of the mammalian genome, particularly focusing on the mouse genome. It identifies the transcription start and termination sites of 181,047 transcripts, including 16,247 novel protein-coding transcripts. The research reveals significant transcriptional variation due to alternative promoter usage, splicing, and polyadenylation, resulting in a detailed map of genomic transcriptional activities, which can facilitate further comparative studies on mammalian gene regulation in various biological contexts.