β-Chemokine MDC and HIV-1 Infection (original) (raw)

AI-generated Abstract

The study investigates the role of the β-chemokine macrophage-derived chemokine (MDC) in inhibiting HIV-1 infection. While a truncated form of MDC, (−2)MDC, was found to inhibit HIV-1 strains in vitro, full-length MDC was determined to be a potent CCR4 ligand without blocking HIV-1 infection across various cell types. The findings highlight the complexity of MDC's interaction with HIV-1 and suggest limitations in its antiviral applicability.

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