Changing Pattern of Hepatitis A Virus Epidemiology in an Area of High Endemicity (original) (raw)

Continuous monitoring on HAV seroepidemiology represent a major tool to assess the risk of HAV infection and to identify appropriate preventive measures in different societies. Being familiar with HAV epidemiology, can help health policy makers to choose the more effective and tailored measures to control the risk of infection. Background: Continuous assessment of hepatitis A virus (HAV) seroepidemiology is a useful tool to control the risk of infection. Objectives:This study aimed to evaluate the changing patterns of anti-HAV seroprevalence in a population,which isgenerally considered to be anarea of high endemicity. Patients and Methods: Overall, the results of 3349 sera collected during the period 2005-2008 from patients attending the University Hospital of Cagliari, Italy were studied; their mean age was 52.7 years, (s + 16.22). Patients with liver disease were excluded from the study. Age specific seroprevalence results were compared with those observed in similar previous studies carried out in the same area. Results: The overall prevalence of anti-HAV was 74.6% with consistently lower values in subjects younger than 40 years (17.5%; P < 0.0001) particularly in those under 30 years of age (8.9%, CI 5.8-11.9). A significant declining trend in age specific seroprevalence has been foundin people under 30 years;