Differential apathy profiles in Alzheimer’s disease and Parkinson’s disease (P6.198) (original) (raw)

Neurology, 2015

Abstract

BACKGROUND: Apathy is one manifestation of impaired goal-directed behavior (GDB) and is highly prevalent in individuals with neurodegenerative diseases (ND). Core GDB processes include initiation, planning and motivation; when any of these processes is compromised, apathy results. We examined impaired GDB in Alzheimer’s disease (AD) and Parkinson’s disease (PD) and compared apathy profiles across these two patient groups. DESIGN/METHODS: Participants included 23 subjects with mild AD, 17 PD subjects, and 20 demographically matched normal controls (NC). Caregivers completed the Neuropsychiatric Inventory (NPI) and all subjects had apathy according to the NPI frequency by severity score >1. Subjects were administered the Philadelphia Apathy Computerized Test (PACT), a novel reaction time test that quantifies three components of GDB: initiation, planning, and motivation. Independent samples t-tests were used to compare PACT latencies for each disease group relative to NC then betwee...

nicholas lim hasn't uploaded this paper.

Let nicholas know you want this paper to be uploaded.

Ask for this paper to be uploaded.