Determination of Chlorpyrifos and its Metabolites in Rat Blood Using Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry (original) (raw)

Journal of Liquid Chromatography & Related Technologies, 2007

Abstract

A method has been developed to quantify chlorpyrifos (O,O‐diethyl O‐[3,5,6,‐trichloro‐2‐pyridyl] phosphorothionate) and its metabolites chlorpyrifos‐oxon (O,O‐diethyl‐O[3,5,6,trichloro‐2‐pyridyl] phosphate) and TCP (3,5,6,‐trichloro‐2‐pyridinol) in rat blood by liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS). Rat blood was treated by liquid‐liquid extraction and the analytes were separated by gradient elution on an Agilent Zorbax Extended‐C8 column (2.0×150 mm, 5 µm). Chlorpyrifos and chlorpyrifos‐oxon were detected in

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