Air Pollution as a Contributor to the Inflammatory Activity of Multiple Sclerosis (original) (raw)
OBJECTIVE Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying the clinical association between air pollution, namely exposure to particulate matter 10 (PM10), and inflammatory activity of multiple sclerosis (MS) METHODS Daily recording of PM10 was obtained by monitors depending on the residence of subjects. Expression of molecules involved in activation, adhesion and migration of T lymphocytes were tested by flow-cytometry in 57 MS patients. We next assessed in vitro the effect of PM10 on expression of C-C chemokine receptors 6 (CCR6) by peripheral blood mononuclear cells (PBMCs), on cytokine production by monocyte-derived dendritic cells (mdDC) and on T cell polarization in PBMC/mdDC mixed cultures. RESULTS We identified a significant correlation between mean PM10 levels and expression of CCR6 CD4 + T circulating cells in MS patients. This was paralleled by the observation in...
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