Influence of Phospholipids and Sequential Kinase Activities on Tau in Vitro (original) (raw)

The study investigates the role of phospholipids and sequential kinase activities in modulating the properties of tau protein in vitro. It explores how phosphatidylserine (PS) affects tau antigenicity and its interaction with various tau antibodies, indicating that PS can alter tau's structural characteristics under specific conditions. The findings suggest that tau interacts with the plasma membrane, highlighting a potential role in signal transduction and providing insights into tau's functions that extend beyond microtubule stability, particularly in the context of neurodegenerative diseases like Alzheimer's.