Effect on in-vitro release of individual and dual contraceptive drug loading from gelatin electrospun fibers (original) (raw)
Related papers
Electrospun Transdermal Patch for Contraceptive Hormone Delivery
Current Drug Delivery, 2019
Background: A transdermal patch for delivery of Levonorgestrel (LNG) can be used for long-acting contraception. Objective: In this study, we designed and characterized a patch made of nonwoven electrospun microfibers comprised of Polycaprolactone (PCL) encapsulating LNG for slow release in a mineral oil matrix. Methods and Results: Scanning electron microscopy showed uniform, randomly oriented PCL fibers with large interconnected voids filled with mineral oil. Thermogravimetric analysis indicated that LNG loaded into PCL fibers had thermal stability up to ~200°C. Differential Scanning Calorimetry suggested that LNG was dispersed in the electrospun fibers without interaction between the LNG and PCL, and without formation of drug crystals. Fourier Transform Infrared spectroscopy and X-ray diffraction results further supported the conclusion that there was no chemical drug–polymer interaction in LNGloaded fibers. Effective in vitro flux (i) from patches into mineral oil was 1.9 µgcm-2h...
Bicomponent fibers of two semi-crystalline (co)polymers, poly(ε-caprolactone), PCL and poly(oxyethylene-b-oxypropylene-b-oxyethylene), Lu were obtained by electrospinning. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations (below and above the drug solubility limit in polymer) in order to determine the effect of drug solubility in polymer, drug state, drug loading and fiber composition on fiber morphology, drug distribution and release kinetics. The high loadings fibers (with drug in crystalline form) showed higher burst and faster release than low drug content fibers, indicating the release was more sustained when the drug was encapsulated inside the fibers, in amorphous form. Moreover, timolol maleate was released faster than acetazolamide, indicating that drug solubility in polymer influences the partition of drug between polymer and elution medium, while fiber composition also controlled drug release. At low loadings, total release was not achieved (cumulative release percentages smaller than 100 %), suggesting that drug remained trapped in the fibers. The modeling of release data implied a three stage release mechanism: a dissolution stage, a desorption and subsequent diffusion through water filled pores, followed by polymer degradation control.
Pharmaceutics, 2019
Electrospun fibers have emerged as a relatively new delivery platform to improve active agent retention and delivery for intravaginal applications. While uniaxial fibers have been explored in a variety of applications including intravaginal delivery, the consideration of more advanced fiber architectures may offer new options to improve delivery to the female reproductive tract. In this review, we summarize the advancements of electrospun coaxial, multilayered, and nanoparticle-fiber architectures utilized in other applications and discuss how different material combinations within these architectures provide varied durations of release, here categorized as either transient (within 24 h), short-term (24 h to one week), or sustained (beyond one week). We seek to systematically relate material type and fiber architecture to active agent release kinetics. Last, we explore how lessons derived from these architectures may be applied to address the needs of future intravaginal delivery pl...
Release of antibiotics from electrospun bicomponent fibers
Cellulose, 2007
Biocompatible nanofibers that are capable of adapting to the physiological conditions of the human body have become increasingly important for clinical applications in recent years. Electrospun fiber mats offer particular advantages due to their large surface area and their sorption/release properties. If loaded with drugs, delivery properties can be tailored to a specific release rate. This research work focuses on poly(L-lactic acid) (PLA) and poly(ε-caprolactone) (PCL) incorporating three different model antibiotics as well as bicomponent fibers made from PLA and PCL containing the same model drugs. Tetracycline and chlorotetracycline hydrochloride, and amphotericin B were selected as model drugs and their release properties and antimicrobial effectiveness studied. The surface morphology and the average diameter of the fibers strongly depended on the individual spinning system which in turn influenced the release of the therapeutic compounds from the fibers. Tetracycline was discharged from PCL at the highest rate while amphotericin B was slowest. PCL almost completely liberated any of the drugs over time while PLA only released about 10% total. By forming bicomponent PCL–PLA fibers surface and release characteristics could be modified to fit a sensible drug delivery.
Electrospun Fibers of Enteric Polymer for Controlled Drug Delivery
The production of electrospun fibers of enteric polymer for controlled delivery of drugs represents a simple and low cost procedure with promising advantages relative to the longer therapeutic window provided by cylindrical geometry in association with intrinsic properties of pH-dependent drug carriers. In this work, we have explored the incorporation of additives (block copolymers of poly(ethylene)-b-poly(ethylene oxide)) into matrix of Eudragit L-100 and the effective action of hybrid composites on delivery of nifedipine, providing improvement in the overall process of controlled release of loaded drug