78-P (original) (raw)

Human Immunology, 2012

Abstract

Aim To establish the impact of anti-HLA antibodies formed prior and/or following heart transplantation in a cohort of 137 pediatric recipients, transplanted between January 2000 and December 2011. Methods Anti-HLA class I and class II antibodies were monitored by traditional CDC methods using donor and panel T and B lymphocytes and SPA for detection of DSA. Endomyocardial biopsies were performed by protocol and whenever rejection was suspected. Results The allograft survival was 89% at 10 years in patients who had no lymphocytotoxic antibodies either before or after transplantation, yet dropped to 55% in patients who developed anti-HLA class I antibodies (p Conclusions All AMR episodes occurring in patients from this study population have documented evidence of complement binding antibodies and C4d deposition in the graft, reinforcing the conclusion that an integrated study of pathologic, immunologic and functional changes is required for timely and effective treatment of AMR.

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