Advances of Cancer Therapy by Nanotechnology (original) (raw)
Related papers
Nanotechnology based approaches in cancer therapeutics
Advances in Natural Sciences: Nanoscience and Nanotechnology, 2014
The current decades are marked not by the development of new molecules for the cure of various diseases but rather the development of new delivery methods for optimum treatment outcome. Nanomedicine is perhaps playing the biggest role in this concern. Nanomedicine offers numerous advantages over conventional drug delivery approaches and is particularly the hot topic in anticancer research. Nanoparticles (NPs) have many unique criteria that enable them to be incorporated in anticancer therapy. This topical review aims to look at the properties and various forms of NPs and their use in anticancer treatment, recent development of the process of identifying new delivery approaches as well as progress in clinical trials with these newer approaches. Although the outcome of cancer therapy can be increased using nanomedicine there are still many disadvantages of using this approach. We aim to discuss all these issues in this review.
NANOTECHNOLOGY: AN EMERGING TOOL FOR EFFECTIVE CANCER TREATMENT
ARTICLE INFO ABSTRACT Nanotechnology is rapidly progressing and is being implemented to solve the problems related to conventional chemotherapeutic agents such as low safety margin, poor water solubility, poor oral availability, normal tissue toxicity and tumor resistance. Nanotechnology promises targeted delivery of drugs and significant improvement in cancer diagnosis, treatment and management. Nanoparticle assisted combination therapies promotes synergism, enhances therapeutic effectiveness, improves pharmacokinetics and suppresses drug resistance. This review sheds light on various nanotechnological platforms as anticancer drug delivery vehicles, raises awareness of the advantages of therapeutic applications of anticancer agents using nanoparticles, minimizing the normal tissue toxicity, drug resistance and treatment of disseminated metastatic cells through targeted therapy.
Nanoparticles-Based Drug Delivery In Cancer Therapy: Current Progress And Challenges
Journal of Pharmaceutical Negative Results, 2022
Cancer is one of the leading causes of mortality and morbidity with a complex pathophysiology. Chemotherapy, radiation therapy, targeted therapy and immune therapies are examples of traditional cancer treatments. However, drawbacks such as cytotoxicity, lack of selectivity, and multi drug resistance provide a significant challenges for a effective cancer treatment. The field of cancer diagnosis and therapy has undergone a revolution with the development of nanotechnology. Due to their unique benefits such as biocompatibility, less toxicity, more excellent stability higher permeability and retention effects and specific targeting, nanoparticles(1-100nm) can be utilized to treat the cancer. There are numerous major categories in to which nanoparticles fall. The unique nanoparticle medication delivery technology makes use of features of the tumour surroundings the tumour. Nanoparticles not only circumvent multi drug resistance but also address the shortcomings of conventional cancer treatments. Moreover, nanoparticles are being aggressively researched as new multi drug resistance pathways are uncovered and analysed. New ideas on cancer treatment have been opened up by the therapeutic implications of nanoformulations. The majority of research, however, is restricted to in vivo and in vitro studies, and the number of authorised nanodrugs has not increased enormously over time. This review covers a wide range of nanoparticle types, and approved nanoparticles for use in the treatment of cancer.
Nanotechnology has achieved the status as one of the vital research endeavors of 21st century, which may be called as “Nano-Century” with nanotechnology making its presence felt in different spheres of lives. Nanotechnology may be defined as the creation of materials, drugs and devices that are used to manipulate matter of size in the range of 1-100nm. Nanotechnology has found its applications in many fields related to medicine including novel drug delivery systems. Many different types of nanosystems have been utilized in diagnostics and therapeutics of various diseases. To subside the disadvantages of conventional cancer therapeutics, nanotechnology has been given considerable attention. The purpose of this expert review is to discuss the impact of nanotechnology in the treatment of the cancer. These have been applied to improve drug delivery and to overcome some of the problems of drug delivery in cancer. Current nanotechnology platforms for cancer therapeutics encompass a vast a...
Revolutionizing Cancer Treatment : The Role of Nanoparticles In Drug Delivery
international journal of engineering technology and management sciences, 2024
In this paper, the role of nanoparticles which is revolutionizing the cancer treatment is presented in brief. The nanoparticles have become a popular choice in drug delivery due to their unique physicochemical properties, which offer various advantages for drug solubility improvement, specific cell targeting, controlled drug release, protection against degradation or elimination, and reduced toxicity to healthy cells. These properties have made nanoparticles a valuable tool in drug delivery for a wide range of diseases. Nanoparticles can be engineered to specifically target cells or tissues, which can increase drug efficacy while reducing side effects. Nanoparticles can also improve drug solubility in water, leading to better delivery and efficacy of poorly soluble drugs. Controlled drug release from nanoparticles provides sustained drug delivery, reducing the need for frequent dosing and improving patient compliance. Additionally, nanoparticles can protect drugs from degradation or...
Cancer nanomedicine: from targeted delivery to combination therapy
Trends in Molecular Medicine, 2015
The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of a variety of diseases, including cancer. The unique properties of nanoparticles, such as large surfaceto volume ratio, small size, the ability to encapsulate a variety of drugs, and tunable surface chemistry, gives them many advantages over their bulk counterparts. This includes multivalent surface modification with targeting ligands, efficient navigation of the complex in vivo environment, increased intracellular trafficking, and sustained release of drug payload. These advantages make nanoparticles a mode of treatment potentially superior to conventional cancer therapies. This article highlights the most recent developments in cancer treatment using nanoparticles as drug-delivery vehicles, including promising opportunities in targeted and combination therapy.
Nanotechnology in cancer therapy
Journal of Drug Targeting, 2013
Cancer is one of the major causes of mortality worldwide and advanced techniques for therapy are urgently needed. The development of novel nanomaterials and nanocarriers has allowed a major drive to improve drug delivery in cancer. The major aim of most nanocarrier applications has been to protect the drug from rapid degradation after systemic delivery and allowing it to reach tumor site at therapeutic concentrations, meanwhile avoiding drug delivery to normal sites as much as possible to reduce adverse effects. These nanocarriers are formulated to deliver drugs either by passive targeting, taking advantage of leaky tumor vasculature or by active targeting using ligands that increase tumoral uptake potentially resulting in enhanced antitumor efficacy, thus achieving a net improvement in therapeutic index. The rational design of nanoparticles plays a critical role since structural and physical characteristics, such as size, charge, shape, and surface characteristics determine the biodistribution, pharmacokinetics, internalization and safety of the drugs. In this review, we focus on several novel and improved strategies in nanocarrier design for cancer therapy.
Impact of Nanoparticles on Cancer Therapy
Tropical Journal of Pharmaceutical Research, 2013
The tremendous contribution of nanotechnology to the treatment and diagnosis of medical diseases has recently attracted the attention of anticancer researchers. Most of the new nanoparticle carriers have improved drug bioavailability and reduced the cytotoxic effects of the drugs. This article presents an overview of the recent advances of nanotechnology in cancer therapy. It covers the mechanisms of cellular uptake for anticancer drugs delivered in nanoscale systems by either active or passive targeting. The various nanoscale systems employed in drug delivery and their immense potential in diagnosis and imaging of cancerous tumors are also addressed.
NANOPARTICLES: PRIVILEGED SCAFFOLD FOR CANCER TREATMENT
Nanotechnology is a regnant scientific field since itcombines knowledge from the various fields.It is a developing technological field with pronounced potential to lead in great breakthroughs so as to meet the escalating demands of man with curtailed side effect to the environment. Although nanotechnology has a number of applications but it has laid down new milestones in the treatment of the most deadly disease “CANCER”. This review encapsulates the role that nanotechnology has played in improving cancer therapy through targeted delivery of drugs thereby reducing systemic toxicity.
International Journal of Applied Pharmaceutics, 2024
The main reason for morbidity and death globally is cancer, which has a complex pathophysiology. There are several traditional treatments for cancer, including chemotherapy, radiation therapy, targeted therapies, and immunotherapies. Multiple drug resistance, cytotoxicity, and lack of specificity pose significant challenges to cancer treatments. Molecular diagnostics and cancer treatment have been transformed by nanotechnology. For cancer treatment, nanoparticles (1-100 nm) are ideal because they are biocompatible, have low toxicity, excellent stability, high permeability, are precise and stable, and can deliver clear and accurate results. There are several main categories of nanoparticles. When it comes to the delivery of nanoparticle drugs, tumour characteristics and the tumour environment are considered. As well as providing advantages over conventional cancer treatments, nanoparticles prevent multidrug resistance, further overcoming their limitations. As new mechanisms are unravelled in studying multidrug resistance, nanoparticles are becoming more critical. Nano formulations have gained a new perspective on cancer treatment due to their many therapeutic applications. The number of approved nanodrugs has not increased significantly despite most research being conducted in vivo and in vitro. A review of nanoparticle oncological implications, targeting mechanisms, and approved nanotherapeutics is presented here. A current perspective on clinical translation is also provided, highlighting its advantages and challenges.