The Spectrum of Dermatological Lesions on Histopathological examination (original) (raw)
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International Journal of Research in Medical Sciences, 2020
Background: Clinical examination may suffice in making diagnosis of most dermatologic disorders but histopathological examination is often required to confirm the diagnosis and further categorize the lesions. Authors carried out this study to analyse the demographic and histomorphological characteristics of skin lesions, to determine the frequency of various dermatological disorders in the region and to evaluate the agreement between clinical and histopathological diagnosis.Methods: Punch biopsies of skin lesions received in histopathology section, were included in the study. Cases over a period of six months were analysed. Clinical details were recorded and histopathological analysis done. Special stains were applied wherever required.Results: Of the 120 cases studied, maximum cases fell in the category of 31-40 years, with male predominance. Authors observed wide variety of non-neoplastic and neoplastic lesions. Infectious diseases were the most common of all pathologies. Leprosy...
Histopathological Spectrum of Dermatological LesionsA Retrospective Study
Journal of Evidence Based Medicine and Healthcare, 2020
BACKGROUND Skin is the largest organ of the human body which protects the internal organs from external environmental stimuli and is vulnerable to a variety of infectious agents and trauma. The spectrum of skin disorders ranges from inflammatory to neoplastic lesions with distinct clinical features and also varies with demographic regions. This study aims to describe the histopathological spectrum of various skin lesions, their frequency, age, sex, and site of distribution of lesions among the outpatients visiting our hospital. METHODS The present study is a retrospective study carried out in the Department of Pathology, KIMS & RF, Amalapuram, AP, India. All the skin biopsies received in the histopathology section from January 2017 to December 2019 were included in the study. RESULTS Out of 280 cases, 197 cases with a definite histological diagnosis were included in the study. Majority of the cases belong to group VI (82 cases), followed by group II (40 cases), group V (28 cases) and group III (25 cases), group IV (14 cases), group VIII (5 cases) and group VII (3 cases). There were no cases in group I. There were 105 non-neoplastic lesions (53.29%) and 92 neoplasms (46.7%) in this study. Most of the skin lesions were in the 31-40 years age group without any obvious gender predilection. CONCLUSIONS Histopathological examination of skin biopsy remains the gold standard technique for diagnosing a variety of skin lesions. Histopathological examination of the skin biopsy in correlation with, clinical history, aids in the accurate diagnosis of the majority of the skin lesions.
Journal of Clinical and Basic Research, 2024
Background: The prevalence of skin diseases varies geographically due to factors, such as etiology, environment, genetics, and lifestyle. The current study aimed to determine the incidence and distribution of skin disorders and to provide a description of the histomorphological spectrum. Methods: This retrospective study was conducted over a period of two years, from June 2021 to May 2023. A total of 202 skin biopsy samples were evaluated. The histopathological examination of the lesions categorized them into eight groups based on the site, pattern of involvement, and cytological features, according to the Lever’s Histopathology of the Skin. Group 1 consisted of diseases limited to the epidermis and stratum corneum; group 2 consisted of diseases with localized superficial epidermal or melanocytic proliferation; group 3 consisted of diseases of the superficial cutaneous reactive unit; group 4 included diseases with acantholytic, vesicular, and pustular morphology; group 5 included diseases with perivascular, diffuse, and granulomatous infiltrate of the reticular dermis; group 6 included tumors and cysts of the dermis and subcutis; group 7 consisted of inflammatory disorders of skin appendages; and group 8 consisted of disorders of the subcutis. Results: A total of 202 skin biopsies were collected from individuals aged 8-87 years. The majority of the cases belonged to the age group of 31-40 years. The male-to-female ratio was 1.2:1. The trunk was the most common site of biopsy, accounting for 40% of the cases, followed by the upper limb in 25% of the cases. Histopathological lesions were categorized into eight groups based on the site, pattern, and cytological features. Neoplastic lesions, both benign and malignant, accounted for 10.9% of the cases. The majority of the lesions were related to group 6, accounting for 38.1% of the cases, with the epidermal cyst being the most common lesion (7.92%). Basal cell carcinoma, observed in 2.97% of the cases, was the most common lesion among the neoplastic lesions. Group 5 lesions were the third most common (19.8%), with leprosy accounting for 9.4% of these cases. Conclusion: Histopathological examination of skin biopsies is considered the gold standard for diagnosis, and it is often supported by ancillary techniques. Leprosy was the most common disease identified in this study, which underscores the importance of effective preventive measures for control.
Patterns of Histomorphological Variants of Skin Diseases in a Rural Tertiary Care Centre
International Journal of Medical and Biomedical Studies, 2021
Background: Skin biopsy is a common procedure in Dermatology practice. The usual intent of skin biopsy is to further characterize the nature of a skin growth or eruption and assist in diagnosis by allowing histopathological evaluation of a tissue sample. Although histopathology remains the gold standard for most dermatologic diagnoses, it must be recognized that not all lesions are amenable to definitive specific histological diagnosis1. Material & Methods: The present study is undertaken in the department of Pathology, Index Medical College Hospital and Research Center, Indore (M.P). This was a cross sectional observational study which included skin biopsy specimen from 122 cases reported for histopathological evaluation attending Skin & VD OPD of the institute from June 2018 to Feb 2020. On the basis of histopathological features these skin disorders were classified in different groups as per Lever’s classification2. Results: out of 116 cases included in the study, maximum cases b...
SSR Institute of International Journal of Life Sciences, 2024
Background: First of all, Skin conditions are far more prevalent in underdeveloped nations. Simple skin ailments like acne and scabies can progress to more serious conditions like toxic epidermal necrolysis & deadly neoplastic conditions. This study was carried out to assess the incidence and distribution site of various skin lesions as well as their prevalence. Methods: The study was conducted at the pathology department of the GMERS Medical College in Gandhinagar, Gujarat, between January 2022 and March 2024. After being prepared, sectioned, and stained with hematoxylin and eosin, skin biopsies were evaluated. Results: Among 125 skin biopsies examined. Microbial illness was the most often seen non-neoplastic histopathological pattern 31(26.05%) followed by noninfectious vesicobullous and vesicopustular disease and 24(20.17%) instances of non-infectious Erythematosus papular & squamous illness. Out of 24 cases (24.40%), leprosy was the most frequent microbiological illness seen. Pemphigus diseases, accounting for 11.76% of cases, was the most prevalent vesicopustular illness, followed by subcutaneous bullous disease, which affected 5 cases (4.20%). Psoriasis was the most prevalent non-infectious Erythematosus papular & squamous illness, accounting for 10 (8.40%) cases, followed by lichen planus in 8 (6.72%) instances. Squamous Cell Carcinoma became the most often seen neoplastic skin lesion, occurring in 3 (2.52%) instances. Conclusions: The investigation verified that leprosy was more common and that microbial diseases predominated. The most common non-infectious vesicobullous & vesicopustular diseases are pemphigus. As different skin lesions may be distinguished by their histomorphological traits, histopathological testing is the norm for accurate diagnosis.
Clinicopathological study of skin lesions at a rural tertiary care centre: Study of 220 cases
Int J Clin Diad Pathol, 2021
Skin biopsy remains the gold standard investigation & irreplaceable diagnostic tool in dermatological diseases. Developing countries have reported higher prevalence of skin diseases and the spectrum of these diseases is highly variable. Here we present a clinicopathological study of skin lesions in 220 cases. Out of 220 skin biopsies studied, 9.5% were inadequate samples, followed by17.27% inflammatory lesions, 53.18% benign and 20% malignant lesions respectively. The age range in the present study was 5 years to 91years with a male to female ratio of 1.8:1. Epidermal cyst was the most common benign lesion while squamous cell carcinoma was the most common malignancy encountered histologically in the present study. Study highlights the range, variation & proportion of various skin lesions at rural tertiary care centre. It emphasizes the importance of skin biopsy in arriving at a diagnosis. Skin biopsy is pivotal in determining the malignant skin lesion which may mimic benign & vice versa.
Esculapio, 2020
Objective: To assess the frequency of various dermatological disorders those require histopathological analysis for definite diagnosis. Methods: We included 669 patients of either gender and all ages in this retrospective study, carried out in the Department of Dermatology, Jinnah Hospital, Lahore for a duration of 2 years. Their clinical data and histopathological reports were analyzed. The dermatoses were categorized into (a) papulosquamous disorders, (b) bullous disorders, (c) eczemas, (d) neoplasia, (e) granulomatous disorders, (f) connective tissue diseases, (g) drug reactions, (h) vasculitides, (i) chronic ulcers and (j) miscellaneous disorders. Results: The frequency of various dermatoses noted were as follows: papulosquamous disorders 28.25%, bullous disorders 11.5%, granulomatous disorders 11.5%, connective tissue diseases 10.61%, miscellaneous disorders 10%, eczemas 9.4%, chronic ulcers 7.17 neoplasia 6.8%, vasculitides 2.84% and drug reactions were 1.79% of total biopsies...
A retrospective audit of skin biopsies done in a tertiary care center in India
International journal of dermatology, 2015
Skin biopsies are an invaluable tool in the diagnostic armamentarium of a dermatologist and have several factors that determine outcome. The aim of this study was to retrospectively assess the quality of data included in the pathology request forms and reports and to assess the level of clinicopathological correlation in the reported biopsy specimens. We retrospectively analyzed 3006 histopathology request forms and reports of skin, mucosal, and nail biopsies to assess the quality of data included in them and assessed the level of clinicopathological correlation in these biopsies. Two hundred discordant histopathology slides were randomly reviewed by a pathologist in the presence of a dermatologist to analyze the causes for discordance. The pathological diagnosis was concordant with clinical diagnosis in 1798 (59.8%) biopsies, partially concordant in 228 (7.6%) biopsies, and discordant in 929 (30.9%) biopsies. In a clinicopathologically concordant category, the duration for reportin...
Histopathological Pattern of Skin Diseases in a Teaching Hospital Puducherry
2014
Aims : This study is conducted to study the prevalence of various skin lesions attending the outpatient department of dermatology over a period of one year dec2012-dec2013. Materials and Methods : A total of 125 cases of skin lesions for over a year were taken for the study. Diagnosis was confirmed by histopathological examination with Hand E stain. Special stains were done wherever required. Results : Out of 125 cases , 30(24%)were reported under the category of non-infectious erythematous papulosquamous diseases , 20(16%) cases of leucocytoclasticvasculitis , 6(4.8%) cases of vesiculobullous and vesiculopustular diseases , 15 (12%)cases were reported as connective tissue disorders amongst which morphea , 12(9.6%)was the commonest , granuloma annulare 1 case(0.8%) , erythema nodosum 2 (1.6%) , 5(4%) cases of cutaneous drug toxicities , infectious etiology was reported in 15(12%) cases , pigmentary disorders of the skin was reported in 5(4%) , 2(1.6%) cases of tumors arising from ep...
Global Academic Journal of Medical Sciences
Introduction: The skin is the largest organ of the integumentary system in human. Dermatological lesions are commonly encountered in all countries and it encompasses a wide spectrum, varies from country to country and various regions within a country. Skin diseases are much common in developing countries. The spectrum varies according to geographic distribution, gender, age, and coexisting disorder. We conducted this study to find out the prevalence of different skin lesions and to evaluate their frequency and site of distribution. Aim of the Study: The aim of this study was to find out the prevalence of different skin lesions and to evaluate their frequency and site of distribution. Methods: This was a descriptive study and was conducted in the Department of Histopathology of Bangladesh Specialized Hospital, Dhaka, Bangladesh during the period from January 2019 to December 2021.We included 133 skin biopsies in our study. Result: Among 133 skin biopsies examined, non-infectious vesi...