Study of Histomorphological Changes of Teratomas in Tertiary Care Hospital (original) (raw)
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Histopathological Spectrum of Teratomas in Paediatric Age
Journal of Evolution of medical and Dental Sciences, 2013
INTRODUCTION: Teratomas are the most common germ cell tumours in paediatric age group and accounts for 3% of all the malignancies in childhood. The term teratoma is derived from the Greek word called teraton which means a monster. They are biologically heterogeneous group of tumours that may be benign, potentially malignant or malignant based on their evolutionary features and site of origin. AIMS AND OBJECTIVES: The present study reviews the classification, gross morphology, histopathological findings and grading of teratomas in paediatric age group. MATERIAL AND METHODS: We analysed 44 patients with teratomas presenting at Department of Pathology, Paediatric Referral Hospital from June 2005 to May 2010. Detailed gross and microscopic examination of all the specimens were done and cases were evaluated and graded according to the amount of immature tissues present. RESULTS: We reviewed 44 patients with teratomas. Majority of the cases (72%) were seen in the age group between 0-1 yea...
Teratomas: A Multimodality Review
Current Problems in Diagnostic Radiology, 2012
Germ cell tumors (GCTs) may occur in both children and adults and include a broad array of histologic subtypes, such as teratoma, seminoma (known as dysgerminoma in the ovary and germinoma in the pineal gland), choriocarcinoma, yolk sac tumor, embryonal cell carcinoma, and mixed GCT. In adults, GCTs occur most commonly in the gonads. In children, sacrococcygeal tumors predominate. Teratomas are a common form of GCT. They are defined histologically as containing tissues derived from all 3 germ cell layers: ectoderm, mesoderm (most teratomas contain fat, an imaging hallmark, which is a mesodermal derivative), and endoderm. Teratomas are also classified as mature or immature, depending on the degree of differentiation of its components, and in adults, immature tumors are more likely to exhibit malignant behavior.
Teratoma in Children: Three cases experience in Sanglah Hospital, Bali, Indonesia
GSC Advanced Research and Reviews, 2021
Teratomas are the most common germ cell tumor, and further classified into mature or immature. Immature teratoma comprise less than one percent of all teratomas and with the peak incidence at birth until four years. They were diagnosed by history taking, physical examination, laboratory, imaging, and pathological anatomy as a gold standard. This report presents our experience of diagnosed, giving treatment with or without surgery and chemotherapy in three patients with teratoma. We report three cases of teratoma, at age six months, eight months and four years old with site of cases are retroperitoneal immature teratoma, cervical teratoma and ovarian immature teratoma. History taking of these patients, they have same symptom such as enlargement of the mass. Two cases were noticed after birth and progressively getting bigger until six and eight months old. One case was noticed when the patient had abdominal pain and was suspected with appendicitis at first. The computed tomography (CT...
Case Report on Sacroccygeal (Teratomas) Germ Cell Tumor
Journal of Pharmaceutical Research International
Sacrococcygeal teratomas are a type of germ cell tumour (GCTs) accounting for 40% of all GCTs of all GCT,s in children. Interestingly 75% occurs in females. Reporting here a case of 3 years old female baby hospitalized for surgical excision of sacrococcygeal teratoma. A female (3-year-old) patient was referred to the pediatric outpatient department at Acharya Vinoba Bhave Rural Hospital Wardha on 19th May 2021. Complaining of swelling on right gluteal region Since 6 month and swelling is increases day by day, pain in back side, fever (Temperature - 101˚F) and tenderness in back side, leg weakness, constipation and she was admitted to Pediatric ward. Surgical excision of sacrocogygeal teratoma was done during her hospitalization. She received one cycle of chemotherapy with antineoplastic medicines. The client discharged after 10 days stay in hospital.
Teratoma in Infants and Children
Iranian Journal of Pediatric Surgery, 2015
• Teratoma • Germcell tumor • Children Background: Teratomas arise from three germ cell layers, the ectoderm, endoderm and mesoderm 1, 2 , and have several degrees of differentiation. We report our experience with teratomas at a tertiary pediatric surgery center. Patients and Methods: The hospital records of all patients with the pathological diagnosis of teratoma treated during 10 years between 2004 and 2014 were reviewed and the following information was obtained: Sex, site of tumor, treatment and outcome. Results: Sixty seven patients consisting of 49 girls (73%) and 18 boys (27%) were treated with teratomas at various sites of the body. These included: sacrococcygeal (SC) 32 patients (27 females& 5 males), ovarian 12 cases, cervical 4 patients (1 females & 3 males), retroperitoneal 9 (5 females & 4 males), Nasopharyngeal 2 patients both of which were females, mediastinal 2 cases (1 female & 1 male) and 5 testicular teratoma patients. All patients underwent surgery, and the most common procedure was total resection in 63(94%) of patients. Twenty eight (42%) received chemotherapy. In follow-up 52(77%) patients were in complete remission, 8(12%) had died, and 4 cases did not attend follow-up visits. Conclusions: Teratomas are a group of tumors with similar histological picture but different behaviors. Sacrococcygeal teratomas are the commonest and the majorities are benign but the risk of malignant transformation increases with age. Management of teratomas is a combination of surgery and chemotherapy which may lead patients to a better prognosis.
Medical Science, 2014
Background Mature cystic teratoma (MCT), usually known as dermoid cysts derived from primordial germ cells. Comparing with different other types of germ cell tumors like dysgerminomas, and endodermal sinus tumors, they are most commonly observed. The aim of this study was to evaluate the prevalence, clinical and pathological characteristics; and complications of MCT of the ovary in Chitwan district, central region of Nepal. Methods A retrospective, hospital based study was carried out in all histopathologically proven cases of MCT from July 2011 to June 2014. Relevant data were retrieved from the records of Pathology Department of Chitwan Medical College-Teaching Hospital. According to the guidelines of World Health Organization (WHO), classification of ovarian tumors was done mainly based on histogenetic principles. Results Seventy four MCTs were studied from 62 patients. Majority of the patients (74.19%) were in reproductive age group of 21-40years. Chief complaint was abdominal pain. Ascites was the most common complication found in 6.45% patients. The rate of torsion was 4.84%; larger tumors underwent torsion more frequently than smaller tumors (P <0.05). Right-sided tumors outnumbered the left-sided tumors. The bilaterality rate was 19.35%. Conclusion Integrated MCT accounts for 49% of all ovarian neoplasm and occur principally during the reproductive years. Postmenopausal women or children sometimes affected. Prevalence rates of torsion were relatively less. Larger tumors have more risk of undergoing torsion than smaller tumors.
Morphological Spectrum of Mature Ovarian Teratoma
Background: Teratomas are usually derived from all the three germinal layers. They present as cysts filled with abundant sebaceous material with hair and may contain cartilage, teeth and bone. Solid teratomas pose diagnostic problems especially when the usual ectodermal components are missing on histological examination. The aim of the study is to determine the morphological spectrum of mature ovarian teratoma and to create awareness about the unusual features. Material & Methods: A prospective study consisting of 247 cases of ovarian lesions received at the Department of Pathology, Peshawar Medical College, Peshawar, from January 2012 to October 2013 from its attached teaching hospitals. The patients' data, gross appearance of the ovarian lesions and microscopic findings were recorded. Results: A total of 247 cases were included in this study out of which 234(94.7%) were benign and 13(5.3%) malignant. The commonest benign lesion was hemorrhagic luteal cyst in 50(20.2%) cases, f...
Case Report of Three Immature Cystic Teratomas in Northern Ghana
Case Reports in Obstetrics and Gynecology, 2019
Background. Preoperative diagnosis of immature cystic teratoma can be challenging for clinicians. In this report, we present three cases. Methods. We describe three women aged 10, 20, and 23 years, respectively, who presented with abdominal masses which were diagnosed by abdominal ultrasound as mature cystic teratomas. All women had emergency laparotomy and oophorectomy. Results. Histopathological examination reported these ovarian tumours to be immature cystic teratomas. This case report also provided a brief summary of the clinicopathological features of all ovarian teratomas diagnosed in two centres during the period of review. Conclusion. Immature ovarian teratoma affects primarily younger patients; it is important for clinicians to have a high sense of suspicion whenever the diagnosis of a germ cell tumour is entertained.