ORIGINAL PAPER The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate (original) (raw)

2016

Abstract

Background We report the determinants of serum levels of vitamin D in a UK melanoma case–control study ben-efitting from detailed exposure and genotyping data. Methods Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D3 measurement adjusted for season, age, sex, and body mass index. Results Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individu-als (-2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (-5.79 for heterozygotes versus wild type, p = \0.0001). Higher levels were associated with

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