A case of drug hypersensitivity due to azathioprine (original) (raw)

Journal of the European Academy of Dermatology and Venereology, 2009

Abstract

© 2008 The Authors JEADV 2009, 23 , 702–738 Journal compilation © 2008 European Academy of Dermatology and Venereology studies have shown that facial ACD occurred at younger ages, predominantly between 20 and 40 years of age. While the frequency of patch test allergens differed between the age groups and the sites of the skin involved, the most common allergen was nickel, irrespective of the age and the localization of the ACD, similar to the previous studies. 1 High prevalence of nickel sensitization in Turkey has been attributed to ear piercing during childhood. 4,5 The frequency of allergens identified in malar, periorbital and perioral ACD indicated a possible relationship with cosmetic products and were similar to those recently reported. 6–10 Periorbital region was the most common affected site in age groups 20–39 years and > 60 years, possibly related to more common use of cosmetic products to this area, which is also more sensitive than any other part of the face. The predominance of women also supported this possibility. On the other hand, some of the allergens were not specific for face and were probably carried by hand to the face (e.g. primin). Because of this, it is very difficult to prepare a specific list of allergens for face. As previously suggested, 9,10 screening standard allergens may be beneficial but not sufficient for most of the patients with facial ACD; therefore, testing to different groups of allergens is recommended for these patients. On the other hand, some of standard allergens showed very low rates of sensitization (< 1% of patients), which may question their presence in standard series for facial ACD. Preparing special trays for patients with face involvement may have value in accelerating the diagnosis, but our results indicated that this was almost impossible since facial ACD may occur by various routes.

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