Formulation and Evaluation of Nifedipine Sustained Release Tablets by Using Different Polymers (original) (raw)
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The purpose of this research work was to formulate and evaluate the sustained release tablets of tablets are prepared by direct compression method. The formulations were optimized by incorporating varying composition of Xanthan gum and guar gum as polymers, lactose as flow aid and magnesium stearate drug, which revealed that there was no physical and chemical interaction occurred. The Pre formulation parameters such as bulk density, tapped density, compressibility index and Hausner's percentage yield was evaluated for tablets. The effect of these variables on drug release also studied. The In using pH 0.1N HCl as dissolution media at 75 rpm speed and temperature of 37 sampling was done at periodic time intervals of 1,4,8,12,16,20 and 24 hours and was replaced by equal volume of dissolution media after each withdraw release at different intervals is estimated using UV method. Based on the evaluation result the formulations F kinetics and Higguchi mechanis the drug release through the matrix was fickian diffusion.
Novel drug delivery systems are the best choice for current scenario of Pharmaceutical and medical demands. Novel drug delivery systems (NDDS) and technologies are very effective but at the end the manufacturing cost of finished dosage form goes on top, because of new materials, time consuming process and machinery. In the current research work we were aiming to develop a new excipient from few commonly available materials by mixing together and binding with a binder. Granules of corn starch and pre-gelatinized starch or soluble starch at certain ratio with a binder, works as sustain release agent in conventional dosage form. Formulation with newly prepared material exhibit neither very slow nor very fast rates of drug release. Compressed tablets were prepared by direct compression with SRmixK and wet granulation method using different concentration of hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC), Eudragits (RS and RL) to scrutinize their influence on tablet properties and drug release profile. In vitro drug release studies were carried out using USP type II apparatus in 900 mL of sodium phosphate buffer (pH 7.4) with 0.5% (w/v) SDS. The total quantity of drug released was determined at 238 nm thru UV-visible spectrophotometer. In vitro dissolution studies designated that hydrophobic polymers significantly reduced the rate of drug release compared to hydrophilic ones in 12 hrs., while SRmixK exhibited the best release profile to sustain the drug release for prolong period.
2008
Mr. Shubhrajit Mantry Department of Pharmaceutics Himalayan Pharmacy Institute Majhitar, E. Sikkim, INDIA Email: manu28pharmcy@gmail.com Phone: +91-7384205300 The aim of the present work was to develop sustained release formulation of Nifedipine and evaluate the In-vitro Drug release, a poorly water soluble drug, hydroxy propyl methyl cellulose (HPMC) with different grade as hydrophilic polymers. Tablets were prepared by wet granulation and direct compression technique by using various ratio of different grades of HPMC. Tablets were evaluated for Friability, Hardness, Weight Variation, Content Uniformity, Thickness and In-vitro drug release. By observing dissolution profile it was concluded that the formulation containing HPMC in the ratio of 1:1 showed acceptable dissolution properties compared to other formulation. This study indicates the hydrophilic matrix tablet of Nifedipine prepared using HPMC of different grade can successfully be employed as sustained release matrix tablet ...
The purpose of the present investigation was to design and evaluate sustained release tablets of a poorly water soluble drug nifedipine, employing hydrophilic polymers Methocel K15M CR and Methocel K100LV CR and to select the best formulation based on pharmacokinetic studies. Direct compression method was used to prepare matrix tablets. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index and drug content. The tablets were subjected to various tests for their physical parameters such as thickness, hardness and friability. In vitro release study was carried out for 12 hours using USP paddle type dissolution apparatus in phosphate buffer with sodium lauryl sulphate (pH 6.8). Quantitative evaluation by mathematical model indicates that formulation containing HPMC K15M CR and HPMC K100LV CR in a ratio of 1:3 showed better dissolution properties compared to other formulations. Korsmeyer's plot indicated that the drug release mechanisms from the matrix tablet followed Fickian mechanism. The study indicates that the hydrophilic matrix tablets of nifedipine prepared using Methocel K15M CR and Methocel K100LV CR can successfully be employed as twice-a-day oral controlled release dosage form in order to improve patient compliance.
Objective: The aim of the present research is to formulate and evaluate matrix tablet of Nifedipine by using hydrophobic and hydrophilic polymer. Method: The Nifedipine matrix tablets were prepared by wet granulation method. Formulated tablets were characterized by parameters like hardness, friability, content uniformity, weight variation and in- vitro release studies. In vitro drug release studies were carried in dissolution apparatus using 900 ml of 0.1N HCL (pH 1.2 buffer) for first 2 hours and remaining 12 hours in phosphate buffer (pH 6.8) containing 1% w/v sodium lauryl sulfate as dissolution medium. The amount of drug released was determined spectrophotometrically at 235 nm. Result: The results of the present study based on the in- vitro dissolution studies showed that formulation F5 was shown drug release upto 92.53% at 14 hours was selected as the best formulation from Nifedipine formulations. All the formulated tablets were evaluated for various physical parameters such as hardness, thickness, friability weight variation and drug content was found to be within the limit. In selected formulation, the calculated regression coefficients for drug release kinetics follows the Korsemayer-peppas and drug transport mechanism follow anomalous transport and non- fickian diffusion mechanism release. Conclusion: The result of the study demonstrated that combination of both hydrophilic and hydrophobic polymers could be successfully employed for formulating sustained-release matrix tablets of nifedipine.
FORMULATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM (FLOATING TABLETS) OF NIFEDIPINE
Among novel drug delivery systems, rate controlled oral drug delivery system forms an important area. Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. Floating Drug delivery system are designed to prolong the gastric residence time after oral administration, and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. Floating drug delivery systems are the systems which are retained in the stomach for a longer period of time. The main aim of the study was to design and evaluate nifedipine floating tablets. Hydroxypropyl methyl cellulose (HPMC K100M) was used as a polymer. This study proves that GFDDS of nifedipine can be designed using HPMC K100M as matrix polymer, which provides nearly zero order release kinetics and thus possible enhancement of oral bioavailability of the drug.
Asian Journal of Pharmaceutics, 2010
T he aim of the present work was to develop controlled release matrix formulation of nifedipine and investigate the effects of both hydrophilic and hydrophobic polymers on in vitro drug release. Matrix tablets were prepared by wet granulation technique using different concentration of hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC), compressible Eudragits (RSpo and RLpo) and their combination in different ratios to examine their influence on tablet properties and drug release profile. Tablets were evaluated by measurement of hardness, friability, content uniformity, weight variation and drug release pattern. Release studies were carried out using USP type II apparatus in 900 ml of sodium phosphate buffer (pH 7.4) with 0.5% (w/v) SDS. The amount of drug released was determined at 238 nm by UV-visible spectrophotometer. In vitro dissolution studies indicated that hydrophobic polymers significantly reduced the rate of drug release compared to hydrophilic ones in 12 hrs and combination of both polymers exhibited the best release profile to sustain the drug release for prolong period of time. As a result, the tablet containing HPMC:EC in ratio of 0.75:1 showed better controlled release pattern over a period of 12 hrs. In selected formulation, the calculated regression coefficients for release models fitted best to zero-order models.
Formulation and Evaluation of Fast Dissolving Tablet of Nifedipine
2020
In the present study, there was an attempt to make rapidly dissolving tablets using the direct dissolution method containing Nifedipine-Mannitol solid dispersion. The main objective of the work was to prepare nifedipine solid dispersion with Mannitol to initiate action. The solid dispersion was prepared by the solvent evaporation method and evaluated for cumulative drug release. FDT was formulated by a direct compression method using different super Disintegrants such as CCS and SSG in different ranges (1–3 %). Preformation studies were performed on the powder mixture for tablets. The flow properties (F1 – F18) of the mixture were evaluated by determining the Carr's index, the Hausner ratio, and the angle of view. Condensate density, tapped density, Carr's index, Hausner ratio and representation of angles. The formulated tablets were evaluated for thickness, hardness, stability, weight variation, wetting time, drug content uniformity, dissolution time, and invitro dissolutio...