Serum αFP Level in Cord Blood of Full Term Neonates Born in Babol City (original) (raw)

2019, Journal of Babol University of Medical Sciences

BACKGROUNDANDOBJECTIVE: Serum alpha-fetoprotein (αFP) level is considered as a diagnostic marker is higher than normal in many congenital tumors such as germ cell, hepatoblastoma, as well as liver and metabolic diseases in neonates. Normal neonates also have a higher level of alpha-fetoprotein than others, so it is important to diagnose this interference. In valid sources, the normal serum alpha-fetoprotein level in infants is related to advanced countries, which may vary in our country. Therefore, this study was conducted to determine the serum levels of alpha-fetoprotein in the umbilical cord blood of term neonates born in Babol and to compare them in two genders. METHODS: This cross-sectional study was performed on 500 neonates (37-42 weeks) born in hospitals in Babol city where physical examination was normal. At birth, 5 ml of umbilical cord blood was taken and samples were sent to the lab for measurement of alpha-fetoprotein. Serum alpha-fetoprotein level was measured by ELISA...

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Serum Alfa-FP Level in Cord Blood of Full Term Neonates Born in Babol City

Journal of Babol University of Medical Sciences, 2019

BACKGROUNDANDOBJECTIVE: Serum alpha-fetoprotein (αFP) level is considered as a diagnostic marker is higher than normal in many congenital tumors such as germ cell, hepatoblastoma, as well as liver and metabolic diseases in neonates. Normal neonates also have a higher level of alpha-fetoprotein than others, so it is important to diagnose this interference. In valid sources, the normal serum alpha-fetoprotein level in infants is related to advanced countries, which may vary in our country. Therefore, this study was conducted to determine the serum levels of alpha-fetoprotein in the umbilical cord blood of term neonates born in Babol and to compare them in two genders. METHODS: This cross-sectional study was performed on 500 neonates (37-42 weeks) born in hospitals in Babol city where physical examination was normal. At birth, 5 ml of umbilical cord blood was taken and samples were sent to the lab for measurement of alpha-fetoprotein. Serum alpha-fetoprotein level was measured by ELISA method and was compared in two genders. FINDINGS: Mean serum  FP levels was 76.57±35.25 ng/ml (range 2.3-160) and it was significantly higher in males (80.54±36.95 vs. 73.69±33.73 ng/ml) which was statistically significant (p=0.002). CONCLUSION: The results of this study showed that the level of alpha-fetoprotein in neonates born in Babol is relatively high and also in males is more than females.

Serum alpha fetoprotein levels in healthy full-term neonates and infants

Marmara Medical …, 2004

Objective: Alpha fetoprotein (AFP) is an important tumor marker in childhood. However, AFP levels remain high during the first few months of life, making clinical interpretation difficult in this period. The aim of the present study is to determine normal AFP levels in healthy full-term neonates and infants followed-up at Kocaeli University Hospital, Department of Pediatrics.

Alpha fetoprotein: Physiology and pathology during pregnancy and application to antenatal diagnosis

Journal of Perinatal Medicine, 1973

Alpha fetoprotein (AFP) is synthesized by the x human fetal liver and yolk sac [8, 9]. During the 12 th-14 th intrauterine weeks the serum concentration of AFP is at its highest, reaching a few milligrams per ml [7]. However, the total amount of AFP in the fetus increases until the 22 nd week of gestation, remaining constant until about the 32 nd week, and thereafter decreasing [7]. In the newborn at term, the serum AFP concentration is 50-ISO^g per ml [19]. AFP remains detectable by immunodiffusion or related methods for about 5 weeks after birth [24]. Greatly increased serum AFP levels cften reappear in adults with primary hepatocellular cancer [25] or teratocarcinomas [1]. Until recently, the occurrence of AFP in maternal serum had been contested [3]. We purified immunochemically human AFP [14] and developed a radioimmunoassay (RIA) for its determination [15]. It became evident thät small amounts (2-16 ng per ml) of AFP are present in normal human serum [15, 16]. This finding has now been confirmed by other groups [6, 13]. AFP levels in maternal serum increase during pregnancy and the highest AFP concentrations occur during the third trimester. The half life of maternal serum AFP after delivery is about 5 days [19]. In amniotic fluid, the AFP concentrations decrease from the 15 th week of gestation, and at term the concentrations are similar to those in maternal serum [19, 21]. Recently, we found that the maternal serum AFP concentration often increases in asso-Curriculum vitae

Maternal and fetal serum transformed alpha-fetoprotein levels in normal pregnancy

Journal of Obstetrics and Gynaecology Research, 2009

Aim: To evaluate transformed alpha-fetoprotein (t-AFP) (a new molecular conformation of alpha-fetoprotein) levels in maternal serum and fetal serum in normal pregnancy. Methods: Prospective longitudinal study. Fifty pregnant women were studied in two groups: 25 were evaluated in each trimester of pregnancy and near term (12, 20, 32 and 36 weeks) and the other 25 were evaluated at the time of planned cesarean section at term. In the first group, maternal serum t-AFP was measured and in the second group, maternal and fetal serum t-AFP were analyzed. Results: Maternal serum t-AFP levels (medians) were 14.73 ng/mL in the first trimester, 28.29 ng/mL in the second trimester, 30.45 ng/mL in the early third trimester and 8.06 ng/mL in late pregnancy. t-AFP levels were significantly higher in maternal than in fetal serum (P < 0.001). There were no significant correlations between AFP and t-AFP levels in maternal versus fetal serum. Conclusions: t-AFP increases during pregnancy until the early third trimester and then falls before delivery. t-AFP levels are higher in maternal than in fetal serum which suggests that native AFP is transformed to t-AFP either in the mother or in the placenta.

Study on Elevated Maternal Serum Alpha-Fetoprotein in Second Trimester and Pregnancy Outcome

2015

This study was a prospective observational study sponsored by DBT (Department of Biotechnology), New Delhi. It was carried out in Gauhati Medical College and Hospital during the period 2014-15 with a total of 202 women whose maternal serum alpha-fetoprotein (MSAFP) was measured between 16 and 20 weeks of gestation. The objective of the study was to determine whether elevated MSAFP level between 16 and 20 weeks of gestation is associated with increased risk of adverse pregnancy outcome including preterm birth, preeclampsia/ eclampsia, SGA, Stillbirth/Neonatal death. MSAFP level was determined by using an immunometric immunoassay technique. Women with MSAFP level ≥ 2.5MoM were defined as elevated MSAFP. Results showed women with elevated MSAFP were significantly more likely to have subsequent adverse pregnancy outcome (70%) compared to women with MSAFP < 2.5 MoM (18.6%) (p<0.0001) with a relative risk of 3.76 (95% confidence interval 2.5 -5.5).It was thus concluded from the stud...

The role of maternal serum alpha-fetoprotein in preterm birth: A literature review

World Journal of Advanced Research and Reviews

Preterm birth is one of the most important global issues. Mortality and morbidity among children under 5 years, including neonates, is affected by preterm birth. A good maternal care, health workers, and health facilities play an important role in the outcome of pregnancy, including preterm birth. An early screening test for pregnancy is crucial to find any abnormality thus preterm birth can be predicted and the following treatment may be applied without delay. One of potential biomarker for the screening test is alpha-fetoprotein (AFP) that can be found in maternal serum. Web-based literature search was carried out using several keywords. This literature review aims to collect data and articles to conclude the correlation of the potential biomarkers in diagnostic of preterm birth.

Pattern of Maternal Serum Alpha-Foetoprotein Immediately Post Partum in Sokoto State, Nigeria

2014

Numerous studies have reported the reference range of maternal serum alphafoetoprotein immediately postpartum, which could help in screening, diagnosis and monitoring of intrauterine anomaly during pregnancy. However such studies are lacking in Sokoto metropolis. The objective of this study is to determine the reference range of maternal serum alpha-fetoprotein (MSAFP) immediately post partum and its association to parity, body mass index (BMI) and 1-minute Apgar score of the babies. A cross-sectional descriptive study was conducted in some selected hospitals in Sokoto metropolis, between March and November 2012. Using semi-structured questionnaire, data on Parity of mothers and 1-minute Apgar score are collected. Four millilitres of peripheral blood are collected immediately post delivery of placenta to determine the MSAFP using Enzyme linked Immunosorbent assay (ELISA) Method. The data was processed using analyse it 221t, the Pd” 0.05 is considered statistically significant. The M...

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