Novel approaches for stability improvement in natural medicines (original) (raw)
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Strategies to Enhance the Stability of Herbal Active
Acta scientific pharmaceutical sciences, 2022
The market for natural products has experienced rapid expansion in recent years. It leads to the creation of numerous proprietary herbal products, the majority of which are composed of multiple ingredients. The development of herbal drug therapies has led to the discovery that many of the drug's components may interact with one another, which has led to severe concerns regarding the stability of such formulations, a crucial topic in the study of phytochemistry and natural medicines. National pharmacovigilance centers (or analogous institutions) will need to have specialized technical knowledge in order to manage herbal medications, in particular, to analyze the reasons of adverse occurrences. This will include qualified professionals in pertinent technical fields and resources to analyze the products in question, for which there is frequently little data and limited access to trustworthy information sources. Additionally, an effort has been made to gather a profile of herbal substances that improve drug bioavailability together with their mechanism of action (where known) and research on this enhancement.
Accelerated stability study of herbal capsules
IOSR Journal of Pharmacy (IOSRPHR), 2012
Many drugs have been used for immuno-modulation and general weakness. From time immemorial herbs have been used due to advantage of Lesser or no side effects. Ashwagandha have been used from past for immuno-modulation and also as anti stress agent. Shilajeet is a unique blend of herbal and a mineral ingredient formed by unique natural process and is used as general tonic stimulant and aphrodisiac of authentic quality. In the present work stability profile of the herbal capsules (Ashwagandha, Shilajeet and Ashwashila) was analyzed. The change in quantifiable components was within 90 % of the initial amount, indicating the stability of the product for more than 2 years at room temperature.
2019
Authors’ Contributions 1 Conception & Study Design, Data Analysis. 2,4 Data Collection. 3 Data Analysis. 5 Drafting. 6 Critical Review. Article info. Received: September 6, 2019 Accepted: October 21, 2019 Funding Source: Nil Conflict of Interest: Nil Cite this article: Ali H, Alvi A, Nawab A, Salman S, Zafar F, Naveed S. Novel Drug Delivery Approaches in Formulation Development; Stability Considerations and Quality Features of Herbal Products. RADS J. Pharm. Pharm. Sci. 2019; 7(3): 155-164. *Address of Correspondence Author: humaali80@live.com Objective: Over the past few years a substantial modification in the drug delivery systems have been noticed which is expected to continue with even a greater velocity in future as well. This is because of the recent developments in the technological aspects and introduction of variety of drug delivery tools and devices in routine healthcare and research sectors. Such advancements have greatly influenced the herbal drug manufacturing technolog...
An Updated Review on Quality Aspects of Herbal Drug and its Formulation
International Journal of Advanced Research in Science, Communication and Technology
Since a very long time ago, medicinal plants have been used to improve human health. Today, they are becoming more and more widely used as pharmaceuticals, supplementary and alternative therapies, food supplements, cosmetics, and, more surprising, medical gadgets. To assess a high-quality medicine, herbal formulations must be standardised. The total of all elements that directly or indirectly affect the safety, efficacy, and acceptability of the drug product makes up the quality of a herbal drug. The field of herbal drugs and formulations is developing quickly nowadays, and there is still much to learn about the standardisation of these products. However, the lack of a standardised parameter hurts herbal treatment. The major limitations are the lack of standardised raw materials, processing methods and of the final product , product formulation and lack of final products, product formulations, and lack of predetermined criteria for quality assurance. By applying current, suitable GM...
Quality Aspects of Herbal Drugs and its Formulation
International Journal of Advanced Research in Science, Communication and Technology
To evaluate a high-quality medicine, herbal compositions must be standardised. The total of all aspects that directly or indirectly influence the safety, efficacy, and acceptance of a drug product is the quality of a herbal drug. The field of herbal drugs and formulations is developing quickly nowadays, and there is still much to learn about the standardisation of these products. However, the lack of a standardised parameter hurts herbal treatment. The primary constraints are the absence of standards for raw materials, processing techniques, and finished goods, product formulas, and absence of quality control standards. To assure the quality, safety, and effectiveness of herbal medicine using contemporary methods, it is required to measure the regulation of herbal medicine.
Review on “Quality Aspects Of Herbal Drug and its Formulations”
International Journal of Advanced Research in Science, Communication and Technology
The medicines are created from various plant parts that are known to have medicinal characteristics, such astheroots,stems,leaves,bark,fruit,seeds,orflowers.Additionally,many common drugs are derived from plants. The word “drugs” actually derives from the French word“ drogue,” which means “dry herbs”.[1]
Stability of Pharmaceutical formulations are oftenly challenged by compatibility between drugs and excipients. The objective of the present study is to identify compatibility between drug:drug and drugs:excipient. Curcumin and Tretinoin were selected as model drug where Ethyl cellulose (EC) and Poly vinyl alcohol (PVA) as excipients. The study was done by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction study (XRD) and Thin layer chromatography (TLC). The spectrophotometric graphs revealed that there was no significant changes in position of functional groups of Curcumin, Tretinoin, EC and PVA (O-H, C=O, C-H str.) in pure drugs and excipients with respect to their physical mixtures. X-ray diffraction study reflects that the characteristic peaks of curcumin appeared at a diffraction angle of 2 at 7.95 0 , 8.80 0 , 12.28 0 , 17.29 0 showing that Curcumin and Tretinoin was present as a crystalline form as well. The R f values of the physical mixtures obtained from TLC study on the 0 th and 30 th day were approximately similar to the R f values of the pure Curcumin and Tretinoin. The above spectrophotometric data and retention factor clearly implies that the synthetic-herbal drug combinations with pharmaceutical excipients are compatible with each other and can be introduced for successful development of novel drug delivery system.
Stability of Pharmaceutical Preparations
MINAR International Journal of Applied Sciences and Technology
Pharmaceutical product must be chemically, physically and therapeutically stable to ensure the health and preventive aspect. We have to study the effect of many factors on drug formulation as well as packaging and storage. Stability of pharmaceutical preparation act as the identity card of the drug to reach the pharmacy, the hospital, and the consumer in general, without this identity, it is not possible to approve the drug healthily or in circulation. Furthermore, stability mentoring of pharmaceutical preparations provides information about many physiochemical parameters as rate, and order of decomposition reaction of active ingredients, or the expected interaction with the other ingredients. In order to follow the stability of any pharmaceutical product, an analytical method must be available and convenient for the chemical nature of the product, the analytical procedure must be validated by the accuracy, precision, recovery as well as sensitivity, selectivity proved with statisti...
Accelerated Stability Study of Majoone Falasifa (A Unani Herbal Formulation)
Journal of Biological & Scientific Opinion, 2015
Present study was conducted to evaluate shelf life of Majoone falasifa at accelerated storage conditions. In-house prepared Majoone falasifa packed in multiple air tight transparent PET containers was challenged with temperature and humidity at 40±2 o C/75±5%RH in photo-stability chamber for the period of six months. Packs were tested for various analytical parameters at zero, one, three and six month. Another two packs of MF was evaluated for photostability at overall illumination of 1.2 million lux hours with UV energy of 200Watt hours/square meter and 2.4 million lux hours with UV energy of 400Watt hours/square meter light intensity .No significant change in organoleptic characters of Majoone falasifa were observed at accelerated thermo-humidity condition till six month as well as in photostability at 2.4 million lux hours with UV energy of 400Watt hours/square meter light intensity. The changes in moisture content, ash value, pH, alcohol and water soluble matter, successive extractives, saponification value, iodine value, acid value and total alkaloid was less than 5%. HPLC showed minimum changes. Microbial studies were in confirmation to the WHO guideline. The present study showed that the shelf life of Majoone falasifa was up to 20 months.
RECENT ADVANCES IN HERBAL FORMULATION STANDARDIZATION -A REVIEW
Recently peoples are getting attracted towards traditional medicines due to many advantages. Herbal formulations have reached substantial acceptability as therapeutic agents for a number of diseases. Although, most of these applications are rare, it is however a known fact that over 80% of the community depends on Ayurveda and herbal medicines for healthy lifestyle. This raise in the use of herbal product has also given rise to various forms of misuse and falsification of the formulation leading to consumer's and manufacturer's despondency and in some cases harmful effects.(1) The development of genuine analytical techniques which can reliably profile the phytochemical configuration, including quantitative analysis of marker/Biologically active compounds and other major constituents, is a major challenge to Researcher. Standardization is an important step in creating a consonant biological activity, a standardized chemical profile or simply a quality assurance system for herbal Formulation manufacturing. In present review article various traditional methods as well as conventional approaches are discussed. Recent advancements includes DNA fingerprinting, sophisticated analytical techniques, Chromatographic Markers Analysis etc are observed. Sophisticated Analytical Techniques and Chromatographic technique contributions towards standardization of polyherbal formulation is also reported.