Post COVID-19 vaccination side effects and associated factors among vaccinated health care providers in Oromia region, Ethiopia in 2021 (original) (raw)
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Journal of Multidisciplinary Healthcare
Background: Vaccines are a powerful choice to stop disease outbreaks, including covid-19. However, people are hesitant to take vaccinations due to uncertainty about side effects. So, this study aimed to assess covid-19 vaccine side-effect and its associated factors among healthcare workers in Dessie comprehensive specialized hospital, in Ethiopia. Methods: An institution-based cross-sectional study was conducted at Dessie Comprehensive and Specialized Hospital among 351 vaccinated healthcare workers from April 25 to May 25, 2021. Self-administrated questionnaires were used by consented health workers. Variance inflation factor (VIF) was used to assess the multicollinearity of independent variables. Bivariable and multivariable binary logistic regression were used to identify significant factors of vaccine side effects. The adjusted odds ratio (AOR) with a 95% confidence interval (CI) was reported as the effect size. Statistical significance was considered at p-value <0.05. Results: Overall, of vaccinated healthcare workers, 56.98% (95% CI, 50.86-61.26%) experienced at least one side effect. The majority of the side effects were fever (44.44%), headache (39.03%), fatigue (27.35%), injection site pain (25.93%), and nausea (24.22%). Healthcare workers with (≥10 years) of work experience (AOR: 3.74, 95% CI, 1.32-10.59), Hesitancy to take the first dose of the Covid-19 vaccine (AOR: 3.01, 95% CI, 1.82-4.99), underlying chronic disease (AOR: 14.41, 95% CI, (5.07-40.92)), being on antihypertensive medication (AOR: 0.15; 95% CI (0.02-0.93)), and unsafe perception of vaccine safety (AOR:3.50; 95% CI, 1.43-8.57) were independent factors of Covax vaccine side effect development. Conclusion: Overall, common vaccine side effects were identified in healthcare workers who have taken the Covax vaccine. Healthcare workers with (≥10 years) of work experience, Hesitancy to take the first dose, unsafe perception of vaccine safety, and underlined chronic disease were predictors of vaccine side effect occurrence. So, providing vaccine-related information to the community to be vaccinated is mandatory to reduce hesitancy and flaws regarding vaccine safety.
Perceptions and Experiences of COVID-19 Vaccine Side-Effects Among Healthcare Workers in Southern Ethiopia: A Cross-Sectional Study, 2021
Background: We examined the perceptions of healthcare workers about the side-effects of COVID-19 vaccine and the types of side-effects they experienced in the post-vaccination period. Methods: An institutional-based cross-sectional survey research design was used in which a semi-structured questionnaire was distributed to collect quantitative data from healthcare workers in Southern Ethiopia that were selected on the basis of a multi-stage cluster sampling technique. After inserting the completed cases into SPSS software, descriptive statistical techniques, such as frequencies, percentages, charts and inferential statistical tool, particularly binary logistic regression analysis, were used to analyze and present the data. Results: Majority (43.6%) of respondents perceive that COVID-19 vaccine will have muscle pain around the injection site, followed by fever (39.9%), problems of blood clots (37.8%), headache (35.6%), fatigue (33.5%), and aching limbs (16%). And 63.6%) of them reported that they have experienced muscle pain around the injection site after receiving the COVID-19 vaccine, followed by fatigue (42%), headache (37.2%), fever (34.2%), redness around the injection site (21.6%), and swelling around the injection site (17.8%). Moreover, 25% reported that the fear of potential side-effects of COVID-19 vaccine inhibited them from taking the vaccine. Above all, it is found that respondents' expectation of COVID-19 vaccine to have such serious side-effects is significantly associated to their educational status (OR = 0.229; P < 0.01; 95%C.I.: 0.080-0.651). Conclusion: While the expectations of most of the healthcare workers regarding the sideeffects of the vaccine are parallel to the normal reactions of the vaccine, a significant proportion of the study participants have reported that they perceive COVID-19 vaccine will have life-threatening side-effects. Such fears have also played a role in affecting vaccine uptake. Therefore, the Ministry of Health, and other concerned government bodies should create further awareness on COVID-19 vaccine and related safety issues.
IJID Regions, 2021
Background: : The safety of COVID vaccines should be continuously followed. This study reports adverse events of the Oxford/AstraZeneca COVID-19 vaccine. Methods: : A prospective single-cohort study design was conducted to assess adverse events following immunization and associated factors of the first dose of Oxford/AstraZeneca's COVID-19 vaccine in Ayder Comprehensive specialized hospital. A structured questionnaire was administered consecutively to 423 participants. Follow-up data were collected 72 hours after vaccination via phone. Bivariate and multivariate logistic regression models were used to find associations between adverse events and independent variables. Statistical significance was declared at P < 0.05. Results: : Out of 423 health care workers approached, 395 responded. At least one adverse event (95% CI: 63.58, 72.77) was reported by 270 participants. Local and systemic symptoms occurred in 46.8% (95% CI: 41.94, 51.79) and 58.48% (95% CI: 53.53, 63.26)], respectively. Muscle ache, fatigue, headache and fever were the most common local symptoms. No reports of hospitalization, disability or death. Age (adjusted odds ratio [AOR] = 0.97, P = 0.048), female sex (AOR = 1.84, P = 0.028), and comorbidity (AOR = 2.28, P = 0.040) were independent predictors of adverse events. Conclusion and recommendation: : Adverse events following immunization are commonly reported after the first dose of the Oxford/AstraZeneca COVID-19 vaccine; age, female sex and comorbidity are independent predictors.
Frontiers in Public Health, 2022
Introduction: Ethiopia is the second most populous country in Africa. Ethiopia received most of its COVID-vaccines through donations. The Oxford AstraZeneca vaccine is the first to be donated to Ethiopia by the COVAX facility. Healthcare workers were the priority population that received the Oxford AstraZeneca COVID-vaccine. However, there was no nationwide study on the safety of the vaccine in Ethiopia. This study aimed to measure the prevalence and predictors of self-reported side e ects of the Oxford AstraZeneca vaccine. Materials and methods: The study employed a cross-sectional design. A sample of healthcare workers who took Oxford AstraZeneca COVIDvaccine was drawn from four regions of Ethiopia; namely, Amhara, Oromia, Somali, and Southwest. Data were collected on sociodemographic characteristics, medical anamnesis, COVID-related anamnesis, and COVIDvaccine anamnesis via telephone interview. Descriptive and inferential analyses were done. The software, IBM SPSS Statistics v. , was used for analyses of data. Results: Out of people, responded (response rate:. %). Female accounted for. % of the respondents. The mean age of the respondents was. years (Standard Deviation (SD) = .).
Risk Management and Healthcare Policy, 2022
The initial response to coronavirus disease 2019 (COVID-19) was non-pharmaceutical interventions (NPIs). Long-term protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection does not appear to be possible by either infection or vaccination. Thus, traditional herd immunity seems impossible. In addition to increasing vaccination rates, NPIs may be needed. Methods: A facility-based cross-sectional study was conducted among vaccinated healthcare workers. The study took place from July 15 to August 15, 2022. A self-administered questionnaire was used for data collection. In a multivariable logistic regression model, a p-value of less than 0.05 was considered statistically significant. Results: Four hundred eleven healthcare workers were included in the study. Sixty percent of participants were fully vaccinated. After vaccination, 10.2% of respondents reported infection with SARS-CoV-2. The study showed that 49.4% of participants had a good knowledge of the efficacy and safety of vaccines against SARS-CoV-2. In this study, 36% of individuals adhered well to the COVID-19 prevention strategies. Good knowledge of the efficacy and safety of SARS-CoV-2 vaccines (AOR = 1.69, 95% CI: 1.03-2.78) increased the odds of implementing preventive measures. Healthcare workers who perceived a low and medium risk of SARS-CoV-2 infection after vaccination and who were knowledgeable about SARS-CoV-2 breakthrough infections were less likely to follow preventive measures. Conclusion: The knowledge of healthcare workers regarding the efficacy and safety of vaccines against SARS-CoV-2 was comparable. However, a large proportion of healthcare workers poorly adhered to prevention practices. Therefore, to reduce the risk of SARS-CoV-2 infection among healthcare professionals, prevention strategies must be continuously evaluated and awareness of the need for preventive measures must be raised even after vaccination.
Background Corona Virus Disease is an acute respiratory illness first discovered and identified in China. Countries are taking various precautions to prevent COVID-19 in accordance with WHO guidelines. Objective The objective of this study is to assess the practice of the COVID-19 prevention strategy post vaccination and associated factors among health professionals in Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia, in 2021. Methods An institutional-based cross-sectional study was carried out at Felege Hiwot Referral Hospital, Bahir Dar Ethiopia. Results In this study, 68.7% (95% CI: (63.7, 73.8)) of health care professionals had good practice of the COVID-19 prevention strategy post vaccination. Sex, 1.76% (95% CI: (1.08, 2.89), Marital status (Married) 1.75% (95% CI: (1.09, 2.93)), and good attitude towards vaccination 3.42% (95% CI: (2.13, 5.48)) were significantly associated with the practices of health care professionals post vaccination. Conclusions The practice...
BMJ public health, 2024
Background The global COVID-19 pandemic poses substantial health challenges. Vaccination is key in preventing COVID-19, particularly among healthcare workers (HCWs), essential in curbing the pandemic. Despite global data on HCWs' vaccine uptake, information about vaccination among HCWs in the Somali Region, Ethiopia, is scarce. Objective This study aimed to assess COVID-19 uptake and determinant factors for HCWs in the Somali Region, Eastern Ethiopia, 2021. Methods A facility-based cross-sectional study was conducted from 20 October 2021 to 30 October 2021, involving 440 systematically selected participants. Data were collected through self-administered questionnaires, cleaned, coded and entered into Epi Info software (V.3.5.1; CDC). Subsequently, the data were exported to Stata software (V14.1) for analysis. Descriptive statistics were used to report frequency, percentage, mean and SD. Multiple logistic regression analysis was performed to predict the relationship between independent and dependent variables. In the final model, statistical significance was determined with a 95% CI and a p<0.05. Result A total of 427 HCWs were involved in this study. About 192 (45%) of the participants had a history of test for COVID-19 and 64 (15%) were tested positive for COVID-19 infection. Three hundred and three (76%) at 95% CI (70.3% to 80.6%) of HCWs got at least one dose of the COVID-19 vaccine. Other professions such as paramedics, environmental health and pharmacist were less likely to get COVID-19 vaccine than nurses (adjusted OR, AOR 0.2; 95% CI (0.06 to 0.53)). Participants who were concerned about the availability of the COVID-19 vaccine were less likely to receive it than individuals who were not concerned (AOR 0.01; 95% CI (0.002 to 0.052)). Conclusion The vaccination uptake among HCWs in the region was relatively low, with the type of profession and concerns about vaccine availability being significant factors affecting the uptake. Contributors YW, TTB, AM, MW, RS, HSM, TS and HA contributed to the conceptualisation, conducted the literature review, design, analysis and the writing of the paper.TTB is the guarantor. All authors read and approved the final submitted paper.
Background Fear of anticipated side effects has hindered the COVID-19 vaccination program globally. We report the uptake and the self-reported side effects (SEs) of the COVID-19 vaccine among Healthcare workers (HCWs) in Mbale City Eastern Uganda. Methods A cross-sectional survey of HCWs at seven different level health facilities was conducted from 6 th September to 7 th October 2021 using a structured self-administered questionnaire. Results COVID-19 vaccine had been received by 119 (69%) participants of which 79 (66%) received the two recommended doses of the AstraZeneca vaccine. Getting vaccinated was associated with working in a lower health facility (aOR= 14.1, 95% CI: 4.9 – 39.6, P=0.000), perceived minor risk of contracting COVID-19 (aOR= 12.3, 95% CI: 1.0 – 44.6, p=0.047), and agreeing that COVID-19 vaccine is protective (aOR= 16.7, 95% CI: 5.6 – 50.4, p=0.000). 97 (82%) of participants experienced side effects to at least one dose of which most were mild on both the first (...
Infection and Drug Resistance
Background: The COVID-19 vaccine is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As a result, 12 billion doses of the COVID-19 vaccination have been given globally as of August 1, 2022. Due to occupational exposure, health professionals obtained priority for COVID-19 vaccination. However, despite the availability of COVID-19 vaccines in countries, there is a discrepancy in the uptake of vaccine among different populations including Health-Care Providers. Objective: Assessments of the factors associated with uptake of COVID-19 vaccination among health-care providers in Addis Ababa, Ethiopia in 2022. Methods: From June 10 to July 10, 2022, a facility-based cross-sectional study was carried out in Addis Ababa, Ethiopia, involving 473 health-care professionals, used descriptive statistics to summarize the participant's characteristics, and multivariable logistic regression to analyze factors affecting COVID-19 vaccination uptake. P-value <0.05 was used to determine the level of significance. Results: The response rate of the participants was 94.2%. The uptake rate of COVID-19 vaccine among health-care providers was 359 (75.8%). Vaccine uptake was positively associated with higher perceived concerns regarding COVID-19 [AOR = 7.45, (4.041-13.754)], higher monthly income, [AOR: 2.623 (1.398 −4.923)] compared those who earned lower, being married [AOR: 2.114, (1.068-4.181)] and being advanced age (36-45) years old [AOR =0.486 (0.258-0.916)] compared to 18-26 years old. However, being female professional reduced the odds of vaccine uptake [AOR = 0.486 (CI; 0.258-0.916)] in contrast of their counterpart. Conclusion: The uptake of COVID-19 vaccine among health professionals is relatively higher than in earlier reports. However, this was not yet sufficient for the level required to achieve herd immunity. Hence, the Ministry of health should work in collaboration to address concerns about the safety and effectiveness of COVI D-19 vaccine to increase COVID-19 vaccine uptake. Moreover, Health professionals, social media, regular media outlet should strengthen health education on concerns of covid-19 infection.
Aim: This study aimed at assessing COVID-19 vaccine hesitancy, adverse events after immunization, and associated factors among the general population during the early phase of the COVID-19 vaccination program in Ethiopia. Subjects and Methods: We conducted a national online survey among 853 Ethiopian general population between June 19 and July 31, 2021, in three languages that included Amharic, Afan Oromo and English. Responses obtained from Google Forms were downloaded in excel formats, filtered, coded, exported, and analyzed using Statistical Package for Social Science (SPSS) version 26. Binary logistic regression was employed to identify factors associated with the outcome variables and p<0.05 was used as the cut-off point to declare the significance of the association. This study was approved by the Ethical Review Committee of the School of Pharmacy, College of Health Sciences, Addis Ababa University (ERB/290/13/2021). Results: Of the 853 study participants, the majority of t...