BSA coated gold nanoparticles exhibit size dependent interaction with lung cancer (A549) cells (original) (raw)

BSA coated gold nanoparticles (AuNPs) were synthesized in various sizes (15, 30, 50, and 70 nm) to examine their interactions with lung cancer A549 cells. The study highlights the importance of protein corona formation, specifically the influence of BSA coating on nanoparticle biocompatibility. Results indicated that while both BSA coated and uncoated AuNPs remain non-toxic at lower concentrations (up to 50 µM), the uncoated particles exhibit increased cytotoxicity at higher concentrations. Importantly, size-dependent cytotoxicity was observed, affirming the significant role of nanoparticle characteristics in mediating cellular interactions.